論文出處：J Ethnopharmacol. 2021 Mar 25;268:113570. doi: 10.1016/j.jep.2020.113570.
論文名稱：Antrodia camphorata extract (ACE)-induced apoptosis is associated with BMP4 expression and p53-dependent ROS generation in human colon cancer cells.
作 者：Ding R, Ning X, Ye M, Yin Y.
出 版 年：2021
分 類：抗癌
論文結論：Ethnopharmacological relevance
Antrodia camphorata (AC) is a rare functional fungus in Taiwan and is known as traditional Chinese medicine. It has been reported to inhibit proliferation and promote apoptosis in human cancer cells.
Aim of the study: To investigate the potential mechanism of apoptosis induced in colon cancer cells by Antrodia camphorata extract (ACE).
Materials and methods
The MTT assay and crystal violet staining were used to determine relative cell viability in vitro at 24 and 48 h. The effects of ACE on apoptosis were determined by Hoechst 33342 staining and flow cytometric analysis following Annexin V-FITC/PI staining. The gene expression profile of HCT116 cells was assessed by the RNA sequencing system. In combination with RNA-seq data and qRT-PCR, Western blot analysis was used to evaluate expression of proteins. The intracellular ROS of HCT116 cells were determined using a DCFH-DA fluorescence probe.
Results
ACE significantly reduces cell viability in a dose-dependent manner and triggers apoptosis. To explore the underlying mechanism, we performed transcriptome analysis of ACE-treated colon cancer HCT116 cells. Bioinformatics analyses showed that ACE treatment is associated with pathways in cancer. We further used Cytoscape to analyze hub genes in this network. Among them, BMP4, which is associated with cancer cell death through regulation of the tumor suppressor p53, was significantly decreased at both mRNA and protein levels in ACE treatment groups. We found that cell death is reversible via inactivation or knockdown of p53 gene and reduction of reactive oxygen species (ROS) generation in response to ACE exposure, indicating that p53 plays an important role in ROS generation induced by ACE. Meanwhile, ROS scavenger NAC was used to verify that cell death is reversible via reduction of ROS.
Conclusion
Our findings demonstrate that ACE has potential as an anticancer agent that induces apoptosis through BMP4 and p53-dependent response to ROS in human colon cancer.
論文出處：Plants (Basel). 2021 Apr 9;10(4):737. doi: 10.3390/plants10040737.
論文名稱：Identification and Isolation of an Intermediate Metabolite with Dual Antioxidant and Anti-Proliferative Activity Present in the Fungus Antrodia cinnamomea Cultured on an Alternative Medium with Cinnamomum kanehirai Leaf Extract.
作 者：Zeng WW, Chen TC, Liu CH, Wang SY, Shaw JF, Chen YT.
出 版 年：2021
分 類：抗癌
論文結論：The fungus Antrodia cinnamomea has been used as a folk medicine for various diseases, especially cancer. When A. cinnamomea is cultured on the original host, an endangered woody plant Cinnamomum kanehirai Hayata, the fungus produces more active ingredients, but its growth is slow. Here, C. kanehirai leaf ethanol extract (KLEE) was used as a substitute for C. kanehirai wood to culture A. cinnamomea on solid medium to shorten the culture period and produce active metabolites en masse. The antioxidant activities of methanol extracts from A. cinnamomea cultured on KLEE (MEAC-KLEE) were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging effect, reducing power, and ferrous ion-chelating effect, and the effective concentration (EC50) values were 0.27, 0.74, and 0.37 mg mL−1, respectively. MEAC-KLEE exhibited specific anti-proliferative activity against a non-small-cell lung cancer cell line (A549) by Annexin V assay. A secondary metabolite (2,4-dimethoxy-6-methylbenzene-1,3-diol, DMMB) present in the extract (MEAC-KLEE) was purified by high-performance liquid chromatography (HPLC) and identified by nuclear magnetic resonance (NMR) spectra. DMMB exhibited moderate antioxidant activity against DPPH radicals and reducing power, with EC50 values of 12.97 and 25.59 μg mL−1, respectively, and also induced apoptosis in A549 cells. Our results provide valuable insight into the development of DMMB for nutraceutical biotechnology.
論文出處：Am J Chin Med. 2021;49(4):983-999. doi: 10.1142/S0192415X21500476.
論文名稱：4-Acetylantrocamol LT3 Inhibits Glioblastoma Cell Growth and Downregulates DNA Repair Enzyme O6-Methylguanine-DNA Methyltransferase.
作 者：Lee SY, Yen IC, Lin JC, Chung MC, Liu WH.
出 版 年：2021
分 類：抗癌
論文結論：Glioblastoma multiforme (GBM) is a deadly malignant brain tumor that is resistant to most clinical treatments. Novel therapeutic agents that are effective against GBM are required. Antrodia cinnamomea has shown antiproliferative effects in GBM cells. However, the exact mechanisms and bioactive components remain unclear. Thus, the present study aimed to investigate the effect and mechanism of 4-acetylantrocamol LT3 (4AALT3), a new ubiquinone from Antrodia cinnamomeamycelium, in vitro. U87 and U251 cell lines were treated with the indicated concentration of 4AALT3. Cell viability, cell colony-forming ability, migration, and the expression of proteins in well-known signaling pathways involved in the malignant properties of glioblastoma were then analyzed by CCK-8, colony formation, wound healing, and western blotting assays, respectively. We found that 4AALT3 significantly decreased cell viability, colony formation, and cell migration in both in vitro models. The epidermal growth factor receptor (EGFR), phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR), Hippo/yes-associated protein (YAP), and cAMP-response element binding protein (CREB) pathways were suppressed by 4AALT3. Moreover, 4AALT3 decreased the level of DNA repair enzyme O6-methylguanine-DNA methyltransferase and showed a synergistic effect with temozolomide. Our findings provide the basis for exploring the beneficial effect of 4AALT3 on GBM in vivo.
論文出處：Int J Biol Macromol. 2021 Feb 15;170:307-316. doi: 10.1016/j.ijbiomac.2020.12.135.
論文名稱：Structural sequencing and anti-inflammatory, anti-lung cancer activities of 1,4-alpha/beta-sulfomalonoglucan in Antrodia cinnamomea.
作 者：Lu MK, Chao CH, Hsu YC, Chang CC.
出 版 年：2020
分 類：抗癌
論文結論：Antrodia cinnamomea is a precious Polyporaceous fungus with various bioactivities. This study reports the chemical identification and biological activities of sulfomalonoglucan, a sulfated polysaccharide (SPS), from the sodium sulfate enriched medium of the title fungus. The SPS-containing fraction was separated by gel filtration chromatography (GFC) to give the title SPS (denoted as Na10_SPS-F3). By analyzing the evidence for key inter-glycosidic linkages in the 1D and 2D NMR spectroscopic data, one possible repeat unit was proposed as: Na10_SPS-F3 inhibited the secretion of tumor necrosis factor (TNF-α) and interleukin (IL)-6 after lipopolysaccharide (LPS) stimulation in RAW264.7 macrophages. Mechanistically, Na10_SPS-F3 downregulated TGFRII also attenuated the LPS-induced IκB-α degradation. Moreover, Na10_SPS-F3 inhibited lung cancer cell H1975 EGFR/ERK signaling. This is the first paper reporting a 3-O-sulfomalonyl glucan (Na10_SPS-F3) with eight 1,4-β-Glc moieties connected with ten 1,4-α-Glc moieties from Antrodia cinnamomea and its anti-inflammatory and anti-cancer activities.
論文出處：J Cosmet Dermatol. 2020 Nov 17. doi: 10.1111/jocd.13847.
論文名稱：Extracts of Antrodia cinnamomea mycelium as a highly potent tyrosinase inhibitor.
作 者：Chen HY, Cheng KC, Wang HT, Hsieh CW, Lai YJ.
出 版 年：2020
分 類：抗癌
論文結論：
Background
Ganoderma has been known as a cure for diseases since ancient times, and been used as a medicinal mushroom for more than 2000 years. By many accounts, Ganoderma lucidum extracts from fruit bodies exhibited the comparable tyrosinase inhibition activity.
Aims
To validate A. cinnamomea mycelia anti-melanogenesis activity. Ethanolic extracts of A. cinnamomea mycelia were evaluated using in vitro cell-free tyrosinase assay, cell-based and zebrafish phenotype-based method. Meanwhile, safety assessment was also conducted to ensure the feasibility as the novel ingredients in cosmetic and pharmaceutic industries.
Methods
The major regulatory enzymes being in charge of cutaneous pigmentation, was investigated in both cell-free and cellular enzyme systems, and in phenotype-based zebrafish model. A high-throughput TLC in vitro screening system was introduced to perform the initial evaluation of those with anti-melanin formation activity.
Results
Among the fractions, 50% ethanol extracted fraction (AC_Et50_Hex) exhibited highest anti-melanin formation activity. AC_Et50_Hex (at 100 ppm) reduced 30% intracellular melanin of B16-F10 cells through suppression of tyrosinase activity and its protein expression. For animal study, not only does AC_Et50_Hex exhibited similar depigmenting efficacy to kojic acid (56.1% vs 52.3%) with lower dosage (50 ppm vs 1400 ppm), but showed less toxicity to zebrafish.
Conclusion
A. cinnamomea mycelium extracts can be an ideal candidate/substitute for skin-whitening since kojic acid has been reported with carcinogenic effect. AC_Et50_Hex was recognized as a potential tyrosinase inhibitor throughout in vitro and in vivo analysis studies. The mass production of A. cinnamomea mycelium from agitated fermentation realizes the natural mushroom extracts for commercial application.
論文出處：Int J Biol Macromol. 2020 Nov 1;162:1476-1483. doi:10.1016/j.ijbiomac.2020.07.201.
論文名稱：Effects of sterol-type elicitors on biochemical characterization of polysaccharides from Antrodia cinnamomea.
作 者：Lin TY, Lu MK, Tseng AJ, Chao CH.
出 版 年：2020
分 類：抗癌
論文結論：Sterols play crucial roles in the physiological functions of organisms. In this study, we examined the chemical and biological effects of sterol type elicitors, including squalene, cholesterol and stigmasterol, on polysaccharides (PSs) of Antrodia cinnamomea. Characteristic studies revealed that squalene and stigmasterol effectively increased the glucose contents in PSs. Specifically, squalene not only induced glucose content but also increased fucose and mannose levels in PSs. However, cholesterol did not induce changes in sugar content in PSs. We further identified that high dose squalene significantly promoted 20% yield (w/w) of PSs as well as significantly increased the glucose, galactose and fucose contents. In addition, the major PSs species had a molecular weight of 21 kDa, and squalene significantly increased its area percentage to 43.54. The biological effects of PSs (squalenePS) from squalene treated A. cinnamomea presented anticancer activities by inhibiting lung cancer cell viability and colony formation. Functional studies revealed that squalenePS reduced the glucose uptake and lactate secretion may correlate to inhibition of AKT activity and downregulation of glucose transporter (GLUT1) expression. Our findings suggested squalene may play vital roles in regulating the PSs assembling and bioactivities of A. cinnamomea. Moreover, squalene may be a potential supplement for adding the culture medium of A. cinnamomea.
論文出處：J Pharm Biomed Anal. 2020 Aug 5;187:113142. doi: 10.1016/j.jpba.2020.113142.
論文名稱：Proteomic analysis of Antrodia Cinnamomea-induced ER stress
in liver cancer cells.
作 者：Chen JF, Tsai YT, Lai YH, Lin CC, Chou HC, Kuo WH, Ko ML, Wei YS, Wang YS, Lin MW, Chen YJ, Lee YR, Chan HL.
出 版 年：2020
分 類：抗癌
論文結論：Antrodia Cinnamomea is a fungus species widely used as a herb medicine for hypertension, cancer and handover. Nevertheless, the biological roles of Antrodia Cinnamomea on the molecular mechanism of liver cancer are not entirely understood. To determine whether Antrodia Cinnamomea is able to be used for the treatment of liver cancer and its molecular mechanism, we examined the effect of Antrodia Cinnamomea on the differential proteomic patterns in liver cancer cell lines HepG2 and C3A as well as in Chang’s liver cell, a normal liver cell, using quantitative proteomic approach. The proteomic analysis demonstrated that abundance of 82, 125 and 125 proteins was significantly altered in Chang’s liver cells, C3A and HepG2, respectively. The experimental outcomes also demonstrated that Antrodia Cinnamomea-induced cytotoxicity in liver cancer cells mostly involved dysregulation of protein folding, cytoskeleton regulation, redox-regulation, glycolysis pathway as well as transcription regulation. Further analysis also revealed that Antrodia Cinnamomea promoted misfolding of intracellular proteins and dysregulate of cellular redox-balance resulting in ER-stress. To sum up our studies demonstrated that the proteomic strategy used in this study offered a tool to investigate the molecular mechanisms of Antrodia Cinnamomea-induced liver cancer cytotoxicity. The proteomic results might be further evaluated as prospective targets in liver cancer treatment.
論文出處：Medicine (Baltimore). 2020 Jul 2;99(27):e20808. doi: 10.1097/MD.0000000000020808.
論文名稱：Antrodia cinnamomea is a potentially effective complementary medicine for adjuvant therapy against breast cancer with bone metastasis: A case report.
作 者：Long H, Hu CT, Prijatelj V, Weng CF.
出 版 年：2020
分 類：抗癌
論文結論：Rationale:
Palbociclib (PAL) is a first-in-class selective inhibitor of the cyclin-dependent kinases 4 (CDK4) and CDK6 and is indicated for the treatment of hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) in combination with fulvestrant (FUL) in postmenopausal women. Antrodia cinnamomea (AC), a well-known Chinese folk medicine in Taiwan, possesses numerous biological capabilities, most notably an anti-tumor effect. However, the clinical use of AC as complementary medicine combined with adjuvant therapy is unexplored. In this case report, we evaluated AC combined with PAL plus FUL to reduce the tumor burden in an MBC patient.
Patient concerns:
A Slovenian woman diagnosed with relapsed bone metastases of breast cancer (BC) was unable to undergo surgery and refused radiation therapy due to fear of side effects; she also feared the side effects of adjuvants. However, she was eager to live with a high quality of life.
Diagnosis:
Stage IV, HR-positive/HER2-negative BC with relapse of bone metastases.
Interventions:
After diagnosis of relapse of bone metastases, she received adjuvant with PAL plus FUL. Additionally, she chose to take AC orally (10 g/d).
Outcomes:
The pain was mostly relieved, and the side effects of adjuvant therapy reduced. Magnetic resonance imaging revealed reduction of tumor size at the fifth month of adjuvant therapy plus AC. After 14 months of adjuvant therapy plus AC, the tumors at the thoracic vertebrae T1 and T3 were found to have shrunk from 35.2 and 12.0 mm to 28.1 and 9.9 mm, respectively. Remarkably, no further metastases were observed.
Lessons:
According to the circulating tumor cells (CTCs) test data, AC had better anti-tumor efficacy on active tumor cells than PAL plus FUL. Thus, AC could be an effective complementary medicine for adjuvant therapy in patients with HR-positive/HER2-negative MBC. Interestingly, continued elevation of carcinoma antigen 15-3 and lactate dehydrogenase levels but decreasing levels of alkaline phosphatase were observed, which may be indicative of the potent efficacy of treatment resulting in massive tumor cell death. The CTCs test may be a sensitive approach to monitor the progression of BC and subsequently evaluate the efficiency of therapy.
論文出處：Int J Mol Sci. 2019 Feb 15;20(4). pii: E833. doi: 10.3390/ijms20040833.
論文名稱：Antrodia cinnamomea, a Treasured Medicinal Mushroom, Induces Growth Arrest in Breast Cancer Cells, T47D Cells: New Mechanisms Emerge.
作 者：Chen YC, Liu YC, El-Shazly M, Wu TY, Chang JG, Wu YC.
出 版 年：2019
分 類：抗癌
論文結論：Ethanol extract of artificially cultured Antrodia cinnamomea (EEAC) inhibited breast cancer cells (T47D cells) proliferation mediated by cell cycle arrest at G1 phase as well induced autophagy. EEAC not only decreased the expression of the cell-cycle-related proteins but also increased the expression of transcription factor FOXO1, autophagic marker LC3 II, and p62. EEAC mediated endoplasmic reticulum stress by promoting the expression of IRE1 (inositol-requiring enzyme 1α), GRP78/Bip (glucose regulating protein 78), and CHOP (C/EBP homologous protein).
論文出處：Phytomedicine. 2019 Jan;52:70-78. doi: 10.1016/j.phymed.2018.09.213. Epub 2018 Sep 27.
論文名稱：Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling.
作 者：Chen JH, T H Wu A, T W Tzeng D, Huang CC, Tzeng YM, Chao TY.
出 版 年：2019
分 類：抗癌
論文結論：Antrocin, an active component of Antrodia cinnamomea, treatment suppressed the viability, migration colony formation and mammosphere generation. Antrocin-mediated anti-cancer effects were associated with the decreased expression of oncogenic and stemness markers such as β-catenin, Akt and Notch1.
論文出處：J Cell Physiol. 2019 Apr;234(4):4125-4139. doi: 10.1002/jcp.27222. Epub 2018 Aug 26.
論文名稱：Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers.
作 者：Hseu YC, Chang GR, Pan JY, Rajendran P, Mathew DC, Li ML, Liao JW, Chen WT, Yang HL
出 版 年：2019
分 類：抗癌
論文結論：
The fermented Antrodia camphorata (AC) exhibits potential for engendering cell-cycle arrest as well as prompting apoptosis and metastasis inhibition in triple-negative breast cancer (TNBC) cells.
1. Rversed the morphological changes (fibroblastic-to-epithelial phenotype) as well as the EMT by upregulating the observed E-cadherin expression.
2. Decrease the observed Wnt/β-catenin nuclear translocation through a pathway determined to be dependent on GSK3β.
3. Inhibited the EMT by downregulating mesenchymal marker proteins like N-cadherin, vimentin, Snail, ZEB-1, and fibronectin; at that same time upregulating epithelial marker proteins like occludin and ZO-1.
論文出處：Sci Rep. 2019 Mar 26;9(1):5145. doi: 10.1038/s41598-019-41653-9.
論文名稱：Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells.
作 者：Huang TT, Lan YW, Chen CM, Ko YF, Ojcius DM, Martel J, Young JD, Chong KY.
出 版 年：2019
分 類：抗癌
論文結論：
Antrodia cinnamomea ethanol extract (ACEE) inhibits lung tumor growth and metastasis by inducing apoptosis and by inhibiting the STAT3 signaling pathway in cancer cells.
1. ACEE treatment increased expression of p53 and Bax, as well as cleavage of caspase-3 and PARP, while reducing expression of survivin and Bcl-2.
2. ACEE reduced the levels of JAK2 and phosphorylated STAT3 in LLC cells.
3. In a murine allograft tumor model, oral administration of ACEE significantly inhibited LLC tumor growth and metastasis without affecting serum biological parameters or body weight. ACEE increased cleavage of caspase-3 in murine tumors, while decreasing STAT3 phosphorylation. ACEE reduced the growth of human tumor xenografts in nude mice.
論文出處：Carbohydr Polym. 2019 Apr 15;210:175-184. doi: 10.1016/j.carbpol.2019.01.078. Epub 2019 Jan 23.
論文名稱：A sulfated glucan from Antrodia cinnamomea reduces Slug expression through regulation of TGFβ/AKT/GSK3β axis in lung cancer.
作 者：Lin TY, Tseng AJ, Qiu WL, Chao CH, Lu MK.
出 版 年：2019
分 類：抗癌
論文結論：SGA, a sulfated glucan from Antrodia cinnamomea, suppressed tumor growth in vitro and in vivo. TGFβ signaling and overexpression of Slug are regarded as the critical events in lung tumor malignancy. SGA inhibited the TGFβ/FAK/AKT axis by inducing lipid-raft-mediated lysosome-dependent TGFβ receptor degradation, resulting in suppressing cancer cell viability and migration.
論文出處：Biomed Pharmacother. 2019 Jan;109:2262-2269. doi: 10.1016/j.biopha.2018.11.101. Epub 2018 Nov 28.
論文名稱：4-Acetylantroquinonol B from antrodia cinnamomea enhances immune function of dendritic cells against liver cancer stem cells.
作 者：Li TY, Chiang BH.
出 版 年：2019
分 類：抗癌
論文結論：
4-acetylantroquinonol B (4-AAQB), a ubiquinone derivative isolated from the mycelium of Antrodia cinnamomea, could inhibit liver cancer stem cell related manifestations and activate the antitumor ability of dendritic cells, and used for liver cancer prevention and immunotherapy.
1. 4-AAQB can inhibit EpCAM, AFP and related pathways of HepG2 cells. Significantly decreases the expression of β-catenin, inhibits the tumorigenicity and decreases the secretion of immune escape related cytokines.
2. 4-AAQB can stimulate the proliferation of immune cells and promote the endocytosis of immature dendritic cells.
3. When co-cultured immature dendritic cells with EpCAM+ HepG2 cells, 4-AAQB enhanced the expression of MHC class I and II on the surface of liver cancer stem cells and dendritic cells, increased the expression of costimulatory molecules CD80 of dendritic cells and cytokines related to immune activation.
論文出處：Chin J Nat Med. 2019 Jan;17(1):33-42. doi: 10.1016/S1875-5364(19)30007-X.
論文名稱：Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice.
作 者：Wu Y, Tian WJ, Gao S, Liao ZJ, Wang GH, Lo JM, Lin PH, Zeng DQ, Qiu DR, Liu XZ, Zhou M, Lin T, Chen HF.
出 版 年：2019
分 類：抗癌
論文結論：Nineteen triterpenes were isolated from the petri-dish cultured Antrodia camphorata (PDCA), and thirteen of them were the unique anthroic acids in Antrodia camphorata, including the main content antcin K. In mice alcohol-induced liver injury model, triglyceride (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) had been reduced by the PDCA powder as well as the main content antcin K, which indicated that the PDCA could protect alcoholic liver injury in mice model and antcin K could be the effective component responsible for the hepatoprotective activities of PDCA against alcoholic liver diseases. triterpenes
論文出處：Cancers (Basel). 2018 Dec 31;11(1). pii: E34. doi: 10.3390/cancers11010034.
論文名稱：Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
作 者：Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH.
出 版 年：2018
分 類：抗癌
論文結論：Antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, ensitizes prostate cancer (PCa) to radiation through constitutive suppression of IGF-1R downstream signaling. Antrocin downregulated PI3K/AKT and MAPK signaling pathways as well as suppressed type 1 insulin-like growth factor 1 receptor (IGF-1R)-mediated induction of β-catenin to regulate cell cycle and apoptosis.
論文出處：Sci Rep. 2018 Nov 27;8(1):17424. doi: 10.1038/s41598-018-35780-y.
論文名稱：Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells.
作 者：Tsai DH, Chung CH, Lee KT.
出 版 年：2018
分 類：抗癌
論文結論：
Antrodia cinnamomea extracts showed cytotoxicity in HCT116, HT29, SW480, Caco-2 and, Colo205 colorectal cancer cells. Whole-genome expression profiling of Antrodia cinnamomea extracts in HCT116 cells was performed. Autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway may represent a new mechanism of anti-colorectal cancer action by Antrodia cinnamomea.
1. Upregulated the expression of the endoplasmic reticulum stress marker CHOP and its downstream gene TRB3.
2. Dephosphorylation of Akt and mTOR as well as autophagic cell death were observed.
3. Demonstrated that Antrodia cinnamomea extracts significantly suppressed HCT116 tumour growth in nude mice.
論文出處：Carbohydr Polym. 2018 Dec 15;202:536-544. doi: 10.1016/j.carbpol.2018.09.009. Epub 2018 Sep 6.
論文名稱：Chemical identification of a sulfated glucan from Antrodia cinnamomea and its anti-cancer functions via inhibition of EGFR and mTOR activity.
作 者：Lu MK, Lin TY, Chang CC.
出 版 年：2018
分 類：抗癌
論文結論：AC-SPS-F3, a sulfated glucan from Antrodia cinnamomea, reduced lung cancer cell viability via inhibition of EGFR and mTOR activity.
論文出處：Int J Biol Macromol. 2018 Aug 22. pii: S0141-8130(18)32863-0. doi: 10.1016/j.ijbiomac.2018.08.112. [Epub ahead of print]
論文名稱：Microelements induce changes in characterization of sulfated polysaccharides from Antrodia cinnamomea.
作 者：Lin TY, Tseng AJ, Chao CH, Lu MK
出 版 年：2018
分 類：抗癌
論文結論：Microelements play pivotal roles for fungal/plant development and end-use properties. CuSO4 and ZnSO4 increased the mycelium yields and promoted sulfated polysaccharides (SPS) production. Anticancer function studies showed that those SPSs inhibit the cell viability of lung cancer A549 cells via downregulation of EGFR signaling.
論文出處：Int J Med Mushrooms. 2018;20(8):727-738. doi: 10.1615/IntJMedMushrooms.2018026983.
論文名稱：Compound of Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes), Induces Protective Autophagy in SPCA-1 Cells through AMPK Inhibition-Independent Blockade of the Akt/mTOR Pathway.
作 者：Yang H, Zhang J, Zhang H, Yang Y, Liu Y, Sun W, Wang W, Jia W.
出 版 年：2018
分 類：抗癌
論文結論：By-1, a maleimide derivative isolated from Taiwanofungus camphoratus, treatment activated autophagy flux in human lung cancer SPCA-1 cells, which confirmed that autophagy was induced by By-1 treatment. By-1 treatment suppressed the Akt-mammalian target of rapamycin (mTOR) pathway and the AMP-activated protein kinase (AMPK) pathway.
論文出處：Int J Med Mushrooms. 2018;20(4):321-335. doi: 10.1615/IntJMedMushrooms.2018025836.
論文名稱：Autophagy Inhibition Enhances SPCA-1 Cell Proliferation Inhibition Induced by By-1 from the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes).
作 者：Yang H, Sun W, Zhang J, Zhang Y, Zhang H, Yang Y, Wu D, Liu Y, Qiankun Z, Min L, Wang WH, Jia W
出 版 年：2018
分 類：抗癌
論文結論：
By-1 (3-isobutyl-l-methoxy-4-[4′-(3-methylbut-2-enyloxy)phenyl]-1H-pyrrole-2,5-dione), a compound from submerged cultures of Taiwanofungus camphoratus, inhibited the growth of SPCA-1 cells by inducing cell cycle arrest and apoptosis.
1. suppress DNA synthesis, cause cell cycle arrest at the S phase, and induce apoptosis in a reactive oxygen species-dependent manner.
2. The expression of caspase-3 and P53 was 4 times higher than that in untreated cells, and the antiapoptotic protein Bcl-2 was decreased 2 times compared with the protein in untreated cells.
論文出處：Sci Rep. 2018 Aug 27;8(1):12914. doi: 10.1038/s41598-018-31209-8.
論文名稱：Antrodia cinnamomea boosts the anti-tumor activity of sorafenib in xenograft models of human hepatocellular carcinoma.
作 者：Wu WD, Chen PS, Omar HA, Arafa EA, Pan HW, Jeng J, Hung JH
出 版 年：2018
分 類：抗癌
論文結論：
The ethanolic extracts of Antrodia cinnamomea (EAC) could effectively sensitize HCC cells to low doses of sorafenib, which was perceived via the ability of the combination to repress cell viability and to induce cell cycle arrest and apoptosis in HCC cells.
1. Enhanced sorafenib activity was mediated through targeting mitogen-activated protein (MAP) kinases, modulating cyclin proteins expression and inhibiting cancer cell invasion.
2. The proposed combination significantly suppressed ectopic tumor growth in mice with high safety margins compared to single-agent treatment.
論文出處：Front Pharmacol. 2018 Jul 18;9:780. doi: 10.3389/fphar.2018.00780. eCollection 2018.
論文名稱：Enhancing the Anticancer Activity of Antrodia cinnamomea in Hepatocellular Carcinoma Cells via Cocultivation With Ginger: The Impact on Cancer Cell Survival Pathways.
作 者：Chen SY, Lee YR, Hsieh MC, Omar HA, Teng YN, Lin CY, Hung JH
出 版 年：2018
分 類：抗癌
論文結論：
The cocultivation of Antrodia cinnamomea (AC) with ginger significantly induced the production of important triterpenoids and EACG was significantly more potent than EAC in targeting HCC cell lines.
1. Inhibited cancer cells growth via the induction of cell cycle arrest at G2/M phase and induction of apoptosis in Huh-7 and HepG2 cells and the activation of caspase-3.
2. EACG modulated cyclin proteins expression and mitogen-activated protein kinase (MAPK) signaling pathways in favor of the inhibition of cancer cell survival.
論文出處：Front Pharmacol. 2018 Dec 17;9:1449. doi: 10.3389/fphar.2018.01449. eCollection 2018.
論文名稱：Antrodia camphorata Mycelia Exert Anti-liver Cancer Effects and Inhibit STAT3 Signaling in vitro and in vivo.
作 者：Zhu PL, Fu XQ, Li JK, Tse AK, Guo H, Yin CL, Chou JY, Wang YP, Liu YX, Chen YJ, Hossen MJ, Zhang Y, Pan SY, Zhao ZJ, Yu ZL.
出 版 年：2018
分 類：抗癌
論文結論：
The ethyl acetate fraction of an ethanolic extract of Antrodia camphorata mycelia (EEAC) reduced cell viability, induced apoptosis, and retarded migration and invasion in cultured hepatocellular carcinoma cells (HCC), HepG2 and SMMC-7721. hepatocellular carcinoma cell lines (HepG2 and SMMC-7721).
1. EEAC downregulated protein levels of phosphorylated and total STAT3 and JAK2 (an upstream kinase of STAT3) in HCC cells. STAT3, but not JAK2, mRNA levels were decreased by EEAC.
2. EEAC also lowered the protein level of nuclear STAT3, decreased the transcriptional activity of STAT3, and downregulated protein levels of STAT3-targeted molecules, including anti-apoptotic proteins Bcl-xL and Bcl-2, and invasion-related proteins MMP-2 and MMP-9.
3. In SMMC-7721 cell-bearing mice, EEAC (100 mg/kg, i.g. for 18 days) significantly inhibited tumor growth. EEAC induced apoptosis and suppressed JAK2/STAT3 activation/phosphorylation in the tumors.
論文出處：Cancers (Basel). 2018 Dec 5;10(12). pii: E491. doi: 10.3390/cancers10120491.
論文名稱：The Disruption of the β-Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo.
作 者：Liu HW, Su YK, Bamodu OA, Hueng DY, Lee WH, Huang CC, Deng L, Hsiao M, Chien MH, Yeh CT, Lin CM.
出 版 年：2018
分 類：抗癌
論文結論：
4-Acetylantroquinonol B (4-AAQB), a bioactive isolate of Antrodia cinnamomea, suppresses the tumor-promoting catenin/LEF1/Stat3 signaling, and inhibited stem cells (CSCs)-induced oncogenic activities in Glioblastoma (GBM) in vitro, with in vivo validation; thus projecting 4-AAQB as a potent therapeutic agent for anti-GBM target therapy. human glioblastoma cell lines (U87MG, DBTRG-05MG).
1. 4-AAQB significantly downregulated β-catenin and dysregulated the catenin/LEF1/Stat3 signaling axis in U87MG and DBTRG-05MG cells, dose-dependently. 4-AAQB⁻induced downregulation of catenin positively correlated with reduced Sox2 and Oct4 nuclear expression in the cells.
2. 4-AAQB markedly reduced the viability of U87MG and DBTRG-05MG cells, effectively inhibited the nuclear catenin, limited the migration and invasion of GBM cells, with concurrent downregulation of catenin, vimentin, and slug; similarly, colony and tumorsphere formation was significantly attenuated with reduced expression of c-Myc and KLF4 proteins.
論文出處：Food Funct. 2018 Dec 13;9(12):6517-6525. doi: 10.1039/c8fo02079e.
論文名稱：Alpha-terpineol affects synthesis and antitumor activity of triterpenoids from Antrodia cinnamomea mycelia in solid-state culture.
作 者：Zhang Y, Li D , Wang Z , Zang W , Rao P , Liang Y , Mei Y .
出 版 年：2018
分 類：抗癌
論文結論：To enhance production of Antrodia cinnamomea triterpenoids (ACTs) from mycelia in solid-state culture, α-terpineol was added to the medium as an elicitor at an optimal concentration of 0.05 mL L-1. In assays of in vitro antitumor activity, ACTs-E (from culture with elicitor) produced stronger viability reduction in several tumor cell lines and stronger apoptosis induction in HeLa in a dose-dependent manner. ACTs-E strongly inhibited synthesis of topoisomerase I (TOP1) and tyrosyl-DNA phosphodiesterase I (TDP1), which are involved in DNA repair, at both transcriptional and protein levels.
論文出處：Leuk Lymphoma. 2018 Oct 2:1-11. doi: 10.1080/10428194.2018.1512709. [Epub ahead of print]
論文名稱：The JAK inhibitor antcin H exhibits direct anticancer activity while enhancing chemotherapy against LMP1-expressed lymphoma.
作 者：Chen YF, Chang CH, Huang ZN, Su YC, Chang SJ, Jan JS.
出 版 年：2018
分 類：抗癌
論文結論：The latent membrane protein 1 (LMP-1) of EBV constitutively activates the JAK/STAT signaling pathway and contributes to the proliferation of EBV-infected primary human B lymphocytes. Antcin H, an analog of the JAK2 inhibitor zhankuic acid A (ZAA), inhibits LMP-1-induced JAK/STAT related signaling and induces lymphoma cell line apoptosis. Moreover, antcin H enhances low-dose methotrexate (MTX) cytotoxicity against lymphoma cells. Treatment of antcin H with low-dose MTX significantly suppressed tumor growth and prolonged the survival of tumor-bearing mice.
論文出處：Int J Biol Macromol. 2018 Dec;120(Pt B):1551-1560. doi: 10.1016/j.ijbiomac.2018.09.162. Epub 2018 Sep 26.
論文名稱：A polysaccharide from Antrodia cinnamomea mycelia exerts antitumor activity through blocking of TOP1/TDP1-mediated DNA repair pathway.
作 者：Zhang Y, Wang Z, Li D, Zang W, Zhu H, Wu P, Mei Y, Liang Y.
出 版 年：2018
分 類：抗癌
論文結論：A polysaccharide (termed ACPS-1) from mycelia of Antrodia cinnamomea under submerged culture was purified by hot water extraction and successive DEAE-52 cellulose and Sephadex G-100 column chromatography. ACPS-1 induced cancer cell lines (HeLa, A431, H22 and S180) apoptosis and cell cycle arrest (cells remained in G2/M phase) through blocking of topoisomerase I/tyrosyl-DNA phosphodiesterase I (TOP1/TDP1)-mediated DNA repair pathway.
論文出處：Int J Mol Sci. 2018 Oct 10;19(10). pii: E3096. doi: 10.3390/ijms19103096.
論文名稱：Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential Biomarker and Drug Target.
作 者：Hung CS, Wang SC, Yen YT, Lee TH, Wen WC, Lin RK.
出 版 年：2018
分 類：抗癌
論文結論：
CCND2 is a common target in lung and breast cancer. As compared with paired normal tissues and healthy individuals, CCND2 promoter hypermethylation was detected in 40.9% of breast tumors and 44.4% of plasma circulating cell-free DNA of patients. Hypermethylation of CCND2 is a potential diagnostic, prognostic marker and drug target, and it is induced by antroquinonol D.
1. CCND2 expression inhibited cancer cell growth and migration ability.
2. Antroquinonol D upregulated CCND2 expression, caused cell cycle arrest, and inhibited cancer cell growth and migration ability.
論文出處：Food Chem Toxicol. 2018 Feb 21. pii: S0278-6915(18)30028-0. doi: 10.1016/j.fct.2018.01.028. [Epub ahead of print]
論文名稱：Antrodia cinnamomea mycelial fermentation broth inhibits the epithelial-mesenchymal transition of human esophageal adenocarcinoma cancer cells.
作 者：Liu YM, Liu YK, Huang PI, Tsai TH, Chen YJ
出 版 年：2018
分 類：抗癌
論文結論：Antrodia cinnamomea mycelial fermentation broth (AC-MFB) was not only able to upregulate the expression of Ecadherin and attenuate the TGF-β-induced overexpression of vimentin and N-cadherin, but it also reversed the TGF-β-induced changes in cell morphology from polygonal to spindle-shaped and delayed the migration potential of human esophageal cancer cells (BE3). And AC-MFB was able to inhibit the epithelial mesenchymal transition (EMT) of esophageal cancer BE3 cells, which was accompanied by Twist and Twist1 downregulation.
論文出處：BMC Complement Altern Med. 2018 May 9;18(1):152. doi: 10.1186/s12906-018-2204-y.
論文名稱：Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway.
作 者：Lin YS, Lin YY, Yang YH, Lin CL, Kuan FC, Lu CN, Chang GH, Tsai MS, Hsu CM, Yeh RA, Yang PR, Lee IY, Shu LH, Cheng YC, Liu HT, Lee KD, Chang DC, Wu CY
出 版 年：2018
分 類：抗癌
論文結論：The ethanol extract of antrodia cinnamomea can inhibit the growth of breast cancer cells and induce apoptosis in these breast cancer cells, including MCF-7 cell and tamoxifen-resistant MCF-7 cell lines. It could be a novel anticancer agent in the armamentarium of tamoxifen-resistant breast cancer management.
論文出處：Int J Mol Sci. 2018 May 24;19(6). pii: E1565. doi: 10.3390/ijms19061565.
論文名稱：Anti-Metastatic Effects of Antrodan with and without Cisplatin on Lewis Lung Carcinomas in a Mouse Xenograft Model.
作 者：Chen PC, Chen CC, Ker YB, Chang CH, Chyau CC, Hu ML
出 版 年：2018
分 類：抗癌
論文結論：Antrodan, derived from the fungal mycelia of Antrodia cinnamomea, provides a novel, complementary therapeutic strategy against cancer metastasis, by attenuating the activities of MMP-2 and -9 through the modulation of STAT3/MAPK/ERK/JNK signaling pathways.
論文出處：Int J Mol Sci. 2018 Mar 9;19(3). pii: E791. doi: 10.3390/ijms19030791.
論文名稱：Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model.
作 者：Wu CH, Liu FC, Pan CH, Lai MT, Lan SJ, Wu CH, Sheu MJ
出 版 年：2018
分 類：抗癌
論文結論：Ethanolic extracts from Antrodia cinnamomea (EEAC) induced cell cycle arrest at the G0/G1 phase resulting decreased cell viability in A549 cells. Also inhibited A549 cell migration and reduced expression of gelatinases.
論文出處：J Ethnopharmacol. 2018 Mar 30. pii: S0378-8741(18)30546-4. doi: 10.1016/j.jep.2018.03.041. [Epub ahead of print]
論文名稱：Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway.
作 者：Huang TT, Lan YW, Ko YF, Chen CM, Lai HC, Ojcius DM, Martel J, Young JD, Chong KY
出 版 年：2018
分 類：抗癌
論文結論：Antrodia cinnamomea ethanol extract (ACEE) produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway.
論文出處：J Ethnopharmacol. 2017 Apr 6;201:117-122. doi: 10.1016/j.jep.2017.02.008. Epub 2017 Feb 4.
論文名稱：Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells.
作 者：Wu TR, Huang TT, Martel J, Liau JC, Chiu CY, Leu YL, Jian WT, Chang IT, Lu CC, Ojcius DM, Ko YF, Lai HC, Young JD
出 版 年：2017
分 類：抗癌
論文結論：lanosta-7,9(11),24-trien-3β,15α,21-triol (Pinicolol B), a lanostanoid compound isolated from Antrodia cinnamomea mycelium and may contribute to the anticancer effects in nasopharyngeal cancer cells (TW02 and TW04).
論文出處：Evid Based Complement Alternat Med. 2017;2017:5052870. doi: 10.1155/2017/5052870. Epub 2017 Nov 2.
論文名稱：Antcin-H Isolated from Antrodia cinnamomea Inhibits Renal Cancer Cell Invasion Partly through Inactivation of FAK-ERK-C/EBP-β/c-Fos-MMP-7 Pathways.
作 者：Chiu KY, Chen TH, Wen CL, Lai JM, Cheng CC, Liu HC, Hsu SL, Tzeng YM
出 版 年：2017
分 類：抗癌
論文結論：Antcin-H, a natural triterpene from Antrodia cinnamomea, inhibited the growth of human renal carcinoma 786-0 cells. That may be an active component existing in Antrodia cinnamomea with anticancer effect.
論文出處：Phytomedicine. 2017 Jan 15;24:39-48. doi: 10.1016/j.phymed.2016.11.006. Epub 2016 Nov 8.
論文名稱：Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer.
作 者：Shang KM, Su TH, Lee WL, Hsiao WW, Chiou CY, Ho BY, Wang SY, Shyur LF
出 版 年：2017
分 類：抗癌
論文結論：AC-3E extracts can be employed as a double-barreled approach to treat human ER+ breast cancer by attacking both cancer cells and tumor-associated blood vessel cells.
論文出處：Mol Med Rep. 2017 Aug 10. doi: 10.3892/mmr.2017.7207. [Epub ahead of print]
論文名稱：Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells by arresting cell cycle progression and inducing apoptosis.
作 者：Wang G, Wan Y, Zhao J, Hong Z
出 版 年：2017
分 類：抗癌
論文結論：Antrodia camphorata (AC) exhibited antiproliferative and growth inhibition effects on HCT‑8 cells via induction of apoptosis and blocking of cell cycle progression, thus suggesting that it may have anticancer properties valuable for potential future therapeutic application for the treatment of colorectal cancer (CRC).
論文出處：J Ethnopharmacol. 2017 Jul 5;208:72-83. doi: 10.1016/j.jep.2017.07.001. [Epub ahead of print]
論文名稱：Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/β-catenin signaling pathways in human colon cancer cells.
作 者：Hseu YC, Chao YH, Lin KY, Way TD, Lin HY, Thiyagarajan V, Yang HL
出 版 年：2017
分 類：抗癌
論文結論：The anti-metastatic and anti-EMT activities of Antrodia camphorata, which may contribute to the development of a chemopreventive agent for colon cancer.
論文出處：J Agric Food Chem. 2017 Jan 11;65(1):51-59. doi: 10.1021/acs.jafc.6b04101. Epub 2016 Dec 20.
論文名稱：Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets.
作 者：Lin HC, Lin MH, Liao JH, Wu TH, Lee TH, Mi FL, Wu CH, Chen KC, Cheng CH, Lin CW
出 版 年：2017
分 類：抗癌
論文結論：Antroquinonol (ANQ) is a ubiquinone derivative from Antrodia camphorata, which exhibits inhibitory activities toward migration/invasion and tumorsphere formation of colon cancer cells. And the first time suppresses stem cell-like properties via targeting PI3K/AKT/β-catenin signaling.
論文出處：Chin Med. 2017 Nov 15;12:33. doi: 10.1186/s13020-017-0154-9. eCollection 2017.
論文名稱：Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells.
作 者：Lai IC, Lai GM, Chow JM, Lee HL, Yeh CF, Li CH, Yan JL, Chuang SE, Whang-Peng J, Bai KJ, Yao CJ
出 版 年：2017
分 類：抗癌
論文結論：The active fraction HS7 from n-hexane extract of Taiwanofungus camphoratus exerts multi-targeting activity on the suppression of AKT-mTOR, ERK and STAT3 pathways and induction of p15, p21 and p27 in EGFR wild-type NSCLC cells. This is suggests its potential as an alternative medicine for the treatment of EGFR TKIs resistant NSCLC.
論文出處：Int J Med Mushrooms. 2017;19(3):225-232. doi: 10.1615/IntJMedMushrooms.v19.i3.40.
論文名稱：Antitumor Effect of By-1 from Spent Broth from Submerged Cultures of Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Higher Basidiomycetes), on A549 Adenocarcinoma Cells.
作 者：Wang WH, Wang LY, Yang HR, Zhang YP, Zhang HN, Fan H, Zhao XL, Zhang JS, Jia W
出 版 年：2017
分 類：抗癌
論文結論：By-1 was obtained from submerged cultures of Taiwanofungus camphoratus. By-1 could dramatically inhibit the viability of A549 cells in vitro. Proliferation rates of A549 cells were significantly inhibited. Increased the number of cells in the G0/G1 phases of the cell cycle. And induce A549 cells apoptosis, and this apoptosis was related to the release of reactive oxygen species (ROS).
論文出處：Int J Biol Macromol. 2017 Feb;95:1144-1152. doi: 10.1016/j.ijbiomac.2016.11.004. Epub 2016 Nov 4.
論文名稱：Molecular mechanism of Antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor β receptor degradation.
作 者：Lu MK, Lin TY, Chao CH, Hu CH, Hsu HY
出 版 年：2017
分 類：抗癌
論文結論：A sulfated polysaccharide of Antrodia cinnamomea (SPS) has been identified as a novel immunomodulatory agent. SPS inhibits the growth of A549 and LLC1 lung cancer cells via the induction of cell cycle arrest and activation of caspase 3 and PARP.SPS suppresses TGFβ-induced intracellular signaling events, including phosphorylation of Smad2/3, FAK, Akt, and cell migration.
論文出處：Carbohydr Polym. 2017 Jul 1;167:229-239. doi: 10.1016/j.carbpol.2017.02.104. Epub 2017 Mar 6.
論文名稱：Characterization of a sulfated galactoglucan from Antrodia cinnamomea and its anticancer mechanism via TGFβ/FAK/Slug axis suppression.
作 者：Lu MK, Lin TY, Hu CH, Chao CH, Chang CC, Hsu HY
出 版 年：2017
分 類：抗癌
論文結論：A sulfated polysaccharides 1,4-β-d-galactoglucan (B86-III) with 1,6-branches was isolated and identified from Antrodia cinnamomea. B86-III inhibited the viability of H1975 lung cancer cells via cell apoptosis, including the activation of caspase 3 and PARP. Also downregulated TGFR I protein levels and inhibited FAK phosphorylation, resulting in inhibition of Slug expression and migration.
論文出處：Nat Prod Res. 2017 Aug 2:1-4. doi: 10.1080/14786419.2017.1320785. [Epub ahead of print]
論文名稱：Constituents from solid-cultured Antrodia camphorata.
作 者：Tong ZB, Cui XH, Wang J, Zhang CL, Zhang YY, Ren ZJ
出 版 年：2017
分 類：抗癌
論文結論：A new naphthalenecarboxaldehyde, named as 1-Naphthalenecarboxaldehyde,3,4,4a,5,6,7,8,8a-octahydro-2-(hydroxymethyl)-5,5,8a-trimethyl. With seven other known compounds of nerolidol, cadinol, herbarulide, 3β-Hydroxy-5a,8a-epidioxyergosta-6,22-diene, ergosta-7,22-diene-3,6-dione, 2,3-dimethoxy-5-methyl-p-benzoquinone and β-sitosterol were obtained from Antrodia camphorata. 2,3-dimethoxy-5-methyl-p-benzoquinone and β-sitosterol exhibited significant toxicity to hepG2 cell.
論文出處：J Nat Prod. 2017 Sep 12. doi: 10.1021/acs.jnatprod.7b00223. [Epub ahead of print]
論文名稱：Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea.
作 者：Chen MC, Cho TY, Kuo YH, Lee TH
出 版 年：2017
分 類：抗癌
論文結論：Twenty antroquinonols isolated from Antrodia cinnamomea IFS006. Antroquinonol A exhibited the most potent activity in human A549 and PC-3 cancer cell lines, with GI50 values of 5.7 ± 0.2 and 13.5 ± 0.2 μM, respectively. Antroquinonols V (9) and W (10) also showed growth inhibitory activity against A549 cells with GI50 values of 8.2 ± 0.8 and 7.1 ± 2.1 μM, respectively.
論文出處：Molecules. 2017 May 6;22(5). pii: E747. doi: 10.3390/molecules22050747.
論文名稱：In Vitro Anticancer Activity and Structural Characterization of Ubiquinones from Antrodia cinnamomea Mycelium.
作 者：Yen IC, Lee SY, Lin KT, Lai FY, Kuo MT, Chang WL
出 版 年：2017
分 類：抗癌
論文結論：Two new ubiquinones, named antrocinnamone and 4-acetylantrocamol LT3, were isolated along with six known ubiquinones from Antrodia cinnamomea (Polyporaceae) mycelium, exhibited potential and selective cytotoxic activity against three human cancer cell lines. The suppression by 4-acetylantrocamol LT3 stopped the cell cycle at the beginning of the G2-M phase.
論文出處：J Ethnopharmacol. 2017 Jun 8. pii: S0378-8741(16)31038-8. doi: 10.1016/j.jep.2017.06.004. [Epub ahead of print]
論文名稱：Antrodia cinnamomea sensitizes radio-/chemo-therapy of cancer stem-like cells by modulating microRNA expression.
作 者：Su YK, Shih PH, Lee WH, Bamodu OA, Wu ATH, Huang CC, Tzeng YM, Hsiao M, Yeh CT, Lin CM
出 版 年：2017
分 類：抗癌
論文結論：Antrodia cinnamomea mycelium and its ethyl acetate extracts showed anti-proliferation effects against all types of CSCs, especially the lung, breast, and head and neck squamous cell carcinoma CSCs. An association between the CSC-inhibitory effect of Antrodia cinnamomea and significant downregulation of several microRNAs and cancer stemness expression levels in brain and breast CSCs. Higher CD133 expression is associated with poor prognosis in glioblastoma and breast cancer patients.
論文出處：Onco Targets Ther. 2016 Oct 27;9:6651-6661. eCollection 2016.
論文名稱：The medicinal fungus Antrodia cinnamomea regulates DNA repair and enhances the radiosensitivity of human esophageal cancer cells.
作 者：Liu YM, Liu YK, Wang LW, Huang YC, Huang PI, Tsai TH, Chen YJ
出 版 年：2016
分 類：抗癌
論文結論：Pretreatment with Antrodia cinnamomea mycelial fermentation broth (AC-MFB) decreased the survival of irradiated esophageal cancer cells, enhanced cell cycle arrest at the G2/M phase, the most radiosensitive phase.
論文出處：Cancer Lett. 2016 Apr 10;373(2):174-84. doi: 10.1016/j.canlet.2015.11.046. Epub 2015 Dec 8.
論文名稱：Inhibition of growth, migration and invasion of human bladder cancer cells by antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, and its molecular mechanisms.
作 者：Chiu KY, Wu CC, Chia CH, Hsu SL, Tzeng YM
出 版 年：2016
分 類：抗癌
論文結論：Antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, induced both intrinsic and extrinsic apoptotic pathways in human bladder cancer 5637 cells, evidenced by increase of Fas, DR5, Bax expression and caspase-3, -8 and -9 activation.
論文出處：Integr Cancer Ther. 2016 Nov 7. pii: 1534735416673907. [Epub ahead of print]
論文名稱：Coenzyme Q0 Enhances Ultraviolet B-Induced Apoptosis in Human Estrogen Receptor-Positive Breast (MCF-7) Cancer Cells.
作 者：Wang HM, Yang HL, Thiyagarajan V, Huang TH, Huang PJ, Chen SC, Liu JY, Hsu LS, Chang HW, Hseu YC
出 版 年：2017
分 類：抗癌
論文結論：Coenzyme Q0 (CoQ0; 2,3-dimethoxy-5-methyl-1,4-benzoquinone), a major active constituent of Antrodia camphorata, treatment inhibits the growth of breast cancer MCF-7 cells, and the cell viability was significantly decreased when the cells were pretreated with UVB irradiation.
論文出處：Int J Mol Sci. 2016 Jun 7;17(6). pii: E893. doi: 10.3390/ijms17060893.
論文名稱：Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds.
作 者：Hong M, Tan HY, Li S, Cheung F, Wang N, Nagamatsu T, Feng Y
出 版 年：2016
分 類：抗癌
論文結論：Use Chinese medicines (CMs) (such as Antrodia camphorate, berberine) and their active compounds may be a promising therapeutic strategy to eradicate cancer by targeting cancer stem cells (CSCs). The underlying molecular mechanisms and related signaling pathways involved in these processes were also discussed and concluded in this paper review.
論文出處：Food Chem Toxicol. 2015 Apr;78:33-41. doi: 10.1016/j.fct.2015.01.012. Epub 2015 Feb 2.
論文名稱：Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.
作 者：Lee WT, Lee TH, Cheng CH, Chen KC, Chen YC, Lin CW
出 版 年：2015
分 類：抗癌
論文結論：Antroquinonol suppressed the migration and invasion of breast cancer MDA-MB-231 cells by suppressing ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and EMT expressions. And inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced invasiveness by MCF7 cells.
論文出處：Integr Cancer Ther. 2015 Mar;14(2):184-95. doi: 10.1177/1534735414564425. Epub 2014 Dec 25.
論文名稱：Efficacy of antioxidants as a Complementary and Alternative Medicine (CAM) in combination with the chemotherapeutic agent doxorubicin.
作 者：Sheu MT, Jhan HJ, Hsieh CM, Wang CJ, Ho HO
出 版 年：2015
分 類：抗癌
論文結論：Ethanolic extract of Antrodia cinnamomea (EEAC) have the potential to be clinically applied to prevent cardiac toxicity and hand-foot syndrome (HFS) and enhance the anticancer efficiency of doxorubicin (Dox).
論文出處：PLoS One. 2015 Feb 6;10(2):e0117111. doi: 10.1371/journal.pone.0117111. eCollection 2015.
論文名稱：Antrodin C inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via suppression of Smad2/3 and β-catenin signaling pathways.
作 者：Kumar KJ, Vani MG, Chueh PJ, Mau JL, Wang SY
出 版 年：2015
分 類：抗癌
論文結論：Antrodin C (ADC), a maleimide derivative isolated from Antrodia cinnamomea, attenuates the TGF-β1-induced Epithelial-to-mesenchymal transition (EMT), migration and invasion of human breast carcinoma through the suppression of Smad2/3 and β-catenin signaling pathways.
論文出處：Toxicol Appl Pharmacol. 2015 Oct 15;288(2):258-68. doi: 10.1016/j.taap.2015.07.025. Epub 2015 Jul 30.
論文名稱：4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype.
作 者：Chang TC, Yeh CT, Adebayo BO, Lin YC, Deng L, Rao YK, Huang CC, Lee WH, Wu AT, Hsiao M, Wu CH, Wang LS, Tzeng YM
出 版 年：2015
分 類：抗癌
論文結論：4-Acetylantroquinonol B (4-AAQB), closely related to the better known antroquinonol, is a bioactive isolate of the mycelia of Antrodia camphorata, have anti-inflammatory, hypoglycemic, vasorelaxative, antiproliferative activity and attenuating stemness-related chemoresistance.
論文出處：Int J Nanomedicine. 2015 Dec 2;10:7265-74. doi: 10.2147/IJN.S95194. eCollection 2015.
論文名稱：Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles.
作 者：Chen YC, Su CY, Jhan HJ, Ho HO, Sheu MT
出 版 年：2015
分 類：抗癌
論文結論：Pretreatment of ethanolic extract of Taiwanofungus camphoratus followed by AmB to HT29 colon cancer cells, the 50% inhibitory concentration of AmB solution was 12 μg/mL, whereas that of Ambicelles was 1 μg/mL, indicating that Ambicelles exerted a greater synergistic anticancer effect. (AmB, amphotericin B; Ambicelles, composed of AmB:lecithin:DSPE-PEG2K in a 1:1:10 weight ratio)
論文出處：Nat Prod Bioprospect. 2015 Oct;5(5):237-46. doi: 10.1007/s13659-015-0072-4. Epub 2015 Sep 28.
論文名稱：Intestinal Absorption of Ergostane and Lanostane Triterpenoids from Antrodia cinnamomea Using Caco-2 Cell Monolayer Model.
作 者：Wang Q, Qiao X, Qian Y, Li ZW, Tzeng YM, Zhou DM, Guo DA, Ye M
出 版 年：2015
分 類：抗癌
論文結論：Used intestinal Caco-2 cell monolayer model to reveal the intestinal absorption property of 14 representative triterpenoids from Antrodia cinnamomea.
論文出處：Biomed Res Int. 2015;2015:604385. doi: 10.1155/2015/604385. Epub 2015 Jun 17.
論文名稱：Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.
作 者：Wang WJ, Wu YS, Chen S, Liu CF, Chen SN
出 版 年：2015
分 類：抗癌
論文結論：The efficacious effect of Antrodia camphorata polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages. And IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were reduced.
論文出處：Mol Clin Oncol. 2015 Nov;3(6):1375-1380. Epub 2015 Sep 15.
論文名稱：A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.
作 者：Lee YC, Ho CL, Kao WY, Chen YM
出 版 年：2015
分 類：抗癌
論文結論：This first in-human phase I study of antroquinonol included patients with metastatic non-small-cell lung cancer. An open-label, dose escalation, pharmacokinetic (PK) study was conducted to determine the maximum tolerable dose (MTD), dose-limiting toxicities (DLTs), and safety/tolerability and preliminary efficacy profiles of antroquinonol. Treatment with antroquinonol was generally safe and well tolerated, without DLTs. And the recommended dose level for a phase II study is ≥600 mg daily.
論文出處：Int J Biol Macromol. 2015 Mar;74:476-82. doi: 10.1016/j.ijbiomac.2015.01.004. Epub 2015 Jan 10.
論文名稱：Anti-metastatic effects of antrodan, the Antrodia cinnamomea mycelia glycoprotein, in lung carcinoma cells.
作 者：Fa KN, Yang CM, Chen PC, Lee YY, Chyau CC, Hu ML
出 版 年：2015
分 類：抗癌
論文結論：Antrodan was isolated from Antrodia cinnamomea mycelia, significantly inhibit invasion and migration of Lewis lung carcinoma (LLC) cells.
論文出處：J Nat Med. 2015 Oct;69(4):513-21. doi: 10.1007/s11418-015-0916-6. Epub 2015 May 8.
論文名稱：2,3,5-Trimethoxy-4-cresol, an anti-metastatic constituent from the solid-state cultured mycelium of Antrodia cinnamomea and its mechanism.
作 者：Lin CC, Chen CC, Kuo YH, Kuo JT, Senthil Kumar KJ, Wang SY.
出 版 年：2015
分 類：抗癌
論文結論：An anti-metastatic compound, 2,3,5-trimethoxy-4-cresol (TMC), was isolated from the solid-state cultured mycelium of Antrodia cinnamomea. TMC effectively suppressed movement, migration and invasion of lung cancer cells. Reduced protein expression of Akt, MMP-2 and MMP-9 and enhanced E-cadherin and TIMP-1 protein expression.
論文出處：PLoS One. 2015 Sep 1;10(9):e0136782. doi: 10.1371/journal.pone.0136782. eCollection 2015.
論文名稱：Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata.
作 者：Chang JS, Kuo HP, Chang KL, Kong ZL
出 版 年：2015
分 類：抗癌
論文結論：ACE polysaccharides, ACE/CS and ACE/S all could damage the Hep G2 cell membrane and cause cell death, especially in the ACE/CS group. The encapsulation of ACE polysaccharides by chitosan-silica nanoparticles may provide a viable approach for enhancing anti-tumor efficacy in liver cancer cells.
論文出處：Biomed Res Int. 2015;2015:415269. doi: 10.1155/2015/415269. Epub 2015 Oct 18.
論文名稱：The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells.
作 者：Lin LT, Tai CJ, Su CH, Chang FM, Choong CY, Wang CK, Tai CJ
出 版 年：2015
分 類：抗癌
論文結論：Ethanolic extract of Antrodia camphorata (TCEE) treatment induced cell cycle arrest and suppressed cell growth on both Hep3B and HepJ5 cells. Expression of cell cycle inhibitors, P21 and P27, and activation of apoptosis executer enzyme, caspase-3, were also induced by TCEE.
論文出處：J Agric Food Chem. 2015 Jan 14;63(1):208-15.
論文名稱：4-Acetylantroquinonol B suppresses tumor growth and metastasis of hepatoma cells via blockade of translation-dependent signaling pathway and VEGF production.
作 者：Chang CH, Huang TF, Lin KT, Hsu CC, Chang WL, Wang SW, Ko FN, Peng HC, Chung CH.
出 版 年：2015
分 類：抗癌
論文結論：4-acetylantroquinonol B (4AAQB), isolated from Antrodia cinnamomea, was observed to inhibit HepG2 and HuH-7 hepatoma cell growth in both in vitro and in vivo models via affecting cell cycle and exhibited pronounced inhibitory effects on HuH-7 tumor growth in xenograft and orthotopic models.
論文出處：J Agric Food Chem. 2015 May 13;63(18):4561-9. doi: 10.1021/jf5059304. Epub 2015 May 5.
論文名稱：Antcin K, an Active Triterpenoid from the Fruiting Bodies of Basswood-Cultivated Antrodia cinnamomea, Inhibits Metastasis via Suppression of Integrin-Mediated Adhesion, Migration, and Invasion in Human Hepatoma Cells.
作 者：Huang YL, Chu YL, Ho CT, Chung JG, Lai CI, Su YC, Kuo YH, Sheen LY
出 版 年：2015
分 類：抗癌
論文結論：Antcin K, ergostane-type triterpenoids of Antrodia cinnamomea, was able to inhibit the metastasis of human hepatoma cells through suppression of integrin-mediated adhesion, migration, and invasion.
論文出處：Am J Chin Med. 2015;43(8):1671-96. doi: 10.1142/S0192415X15500950. Epub 2015 Nov 30.
論文名稱：Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells: The Role of ERp57 and PGK-1.
作 者：Chen YY, Liu FC, Wu TS, Sheu MJ
出 版 年：2015
分 類：抗癌
論文結論：Ethanol extract of fruiting bodies of Antrodia cinnamomea (EEAC) and its active ingredients (i.e., zhankuic acid A, cordycepin, and adenosine) can modulate HCC cancer cells migration through down-regulation of ERp57, PGK-1, MAPK, and PI3K/Akt.
論文出處：J Tradit Complement Med. 2015 Feb 4;6(1):48-56. doi: 10.1016/j.jtcme.2014.11.026. eCollection 2016 Jan.
論文名稱：Antcin K, an active triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, induces mitochondria and endoplasmic reticulum stress-mediated apoptosis in human hepatoma cells.
作 者：Lai CI, Chu YL, Ho CT, Su YC, Kuo YH, Sheen LY
出 版 年：2015
分 類：抗癌
論文結論：Antcin K induced mitochondrial and endoplasmic reticulum stress-mediated apoptosis in human hepatoma cells. The principal mode of Hep 3B cells death induced by antcin K was apoptosis, rather than autophagy or necrosis.
論文出處：Fitoterapia. 2015 Apr;102:115-9. doi: 10.1016/j.fitote.2015.02.010. Epub 2015 Feb 23.
論文名稱：Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium.
作 者：Yen IC, Yao CW, Kuo MT, Chao CL, Pai CY, Chang WL
出 版 年：2015
分 類：抗癌
論文結論：Three new ubiquinone derivatives, antrocamol LT1, antrocamol LT2, and antrocamol LT3, along with two known compounds, were isolated from Antrodia camphorata. Have cytotoxicities against five human cancer cell lines (CT26, A549, HepG2, PC3 and DU-145).
論文出處：Int J Med Mushrooms. 2015;17(6):533-40.
論文名稱：Antitumor Compounds from the Stout Camphor Mushroom Taiwanofungus camphoratus (Higher Basidiomycetes) Spent Culture Broth.
作 者：Jia W, Bai YY, Zhang Z, Feng N, Feng J, Yan MQ, Zhu LN, Jia XC, Wang MD, Zhang JS, Fan H
出 版 年：2015
分 類：抗癌
論文結論：A known compound, 5-(hydroxymethyl) furan-2-carbaldehyde, and a novel compound, 3-isobutyl-1-methoxy-4-(4′-(3-methylbut-2-enyloxy)phenyl)-1H-pyrrole-2,5-dione were isolated from submerged cultures of Taiwanofungus camphoratus. These compounds inhibited the proliferation of K562 and HepG2 tumor cells in vitro.
論文出處：J Pharm Biomed Anal. 2015;111:266-76. doi: 10.1016/j.jpba.2015.04.010. Epub 2015 Apr 10.
論文名稱：Metabolites identification and multi-component pharmacokinetics of ergostane and lanostane triterpenoids in the anticancer mushroom Antrodia cinnamomea.
作 者：Qiao X, Wang Q, Ji S, Huang Y, Liu KD, Zhang ZX, Bo T, Tzeng YM, Guo DA, Ye M
出 版 年：2015
分 類：抗癌
論文結論：The low-polarity ergostanes (antcins B and C) undertook hydrogenation (C-3 or C-7 carbonyl groups) or hydroxylation to produce polar metabolites. High-polarity ergostanes (antcins H and K) and Δ(7,9(11)) lanostanes were metabolically stable. The ergostanes were generally absorbed and eliminated rapidly, whereas the lanostanes remained in the plasma at a low concentration for a relatively long time. High-polarity ergostanes are the major plasma-exposed components of Antrodia cinnamomea, and may play an important role in its therapeutic effects.
論文出處：Oncotarget. 2015 Sep 22;6(28):25741-54. doi: 10.18632/oncotarget.4348.
論文名稱：Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice.
作 者：Huang TH, Chiu YH, Chan YL, Wang H, Li TL, Liu CY, Yang CT, Lee TY, You JS, Hsu KH, Wu CJ
出 版 年：2015
分 類：抗癌
論文結論：Antrodia cinnamomea inhibited proliferation of line-1 lung carcinoma cells and rescued hepatic HepG2 cells from cisplatin-induced cell death in vitro.
論文出處：Food Funct. 2014 Dec;5(12):3224-32. doi: 10.1039/c4fo00720d.
論文名稱：Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-D-glucan derived from the fruiting body of Antrodia camphorata.
作 者：Lee CI, Wu CC, Hsieh SL, Lee CL, Chang YP, Chang CC, Wang YZ, Wang JJ.
出 版 年：2014
分 類：抗癌
論文結論：Analyzed triterpenoids, polysaccharides and 1,3-β-D-glucan, three major effective components in Antrodia camphorata extracts (ACE). And shows great therapeutic potential due to its cytotoxic effects against BxPC-3 cells which include inhibiting cell migration and inducing mitochondria-mediated apoptosis.
論文出處：J Agric Food Chem. 2014 Jun 18;62(24):5625-35. doi: 10.1021/jf4056924. Epub 2014 Jun 6.
論文名稱：Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential.
作 者：Wang SC, Lee TH, Hsu CH, Chang YJ, Chang MS, Wang YC, Ho YS, Wen WC, Lin RK.
出 版 年：2014
分 類：抗癌
論文結論：Antroquinonol D (3-demethoxyl antroquinonol), a new DNA methyltransferase 1 (DNMT1) inhibitor, was isolated from Antrodia camphorata. Inhibited the growth of breast cancer cells (MCF7, T47D, and MDA-MB-231) and the migratory potential.
論文出處：Nutr Res. 2014 Jul;34(7):585-94. doi: 10.1016/j.nutres.2014.06.010. Epub 2014 Jun 24.
論文名稱：Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer.
作 者：Chen WT, Yang TS, Chen HC, Chen HH, Chiang HC, Lin TC, Yeh CH, Ke TW, Chen JS, Hsiao KH, Kuo ML
出 版 年：2014
分 類：抗癌
論文結論：MB-6 is a botanical preparation composed of fermented soybean extract, green tea extract, Antrodia camphorata mycelia, spirulina, grape seed extract, and curcumin extract. That may increase the effectiveness of chemotherapy in patients with metastatic colorectal cancer.
論文出處：Int J Med Mushrooms. 2014;16(6):529-39.
論文名稱：Screening and isolation for anti-hepatofibrotic components from medicinal mushrooms using TGF-(β1-induced live fibrosis in hepatic stellate cells.
作 者：Geng Y, Wang J, Xie M, Lu Z, Xu H, Shi JS, Xu ZH
出 版 年：2014
分 類：抗癌
論文結論：Antrodia camphorata has in vitro anti-hepatofibrotic activity and that there is great potential of new drugs for the treatment of liver fibrosis.
論文出處：J Nat Prod. 2014 Jan 24;77(1):118-24. doi: 10.1021/np400741s. Epub 2014 Jan 3.
論文名稱：Antcamphins A-L, ergostanoids from Antrodia camphorata.
作 者：Huang Y, Lin X, Qiao X, Ji S, Liu K, Yeh CT, Tzeng YM, Guo D, Ye M.
出 版 年：2014
分 類：抗癌
論文結論：Twelve ergostanoids, antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells.
論文出處：Biomed Pharmacother. 2014 Oct;68(8):1007-14. doi: 10.1016/j.biopha.2014.09.008. Epub 2014 Sep 26.
論文名稱：Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells.
作 者：Ho CL, Wang JL, Lee CC, Cheng HY, Wen WC, Cheng HH, Chen MC
出 版 年：2014
分 類：抗癌
論文結論：Antroquinonol inhibited Ras and Ras-related GTP-binding protein activation through inhibition of protein isoprenyl transferase activity, leading to activation of autophagy and associated mode of cell death in cancer cells.
論文出處：Molecules. 2014 Dec 19;19(12):21378-85. doi: 10.3390/molecules191221378.
論文名稱：New and Cytotoxic Components from Antrodia camphorata.
作 者：Lee TH, Chen CC, Chen JJ, Liao HF, Chang HS, Sung PJ, Tseng MH, Wang SY, Ko HH, Kuo YH
出 版 年：2014
分 類：抗癌
論文結論：The solid-state cultured products of Antrodia camphorata, 1(10→6)abeo-ergosta-5,7,9,22-tetraen-3α-ol, citreoanthrasteroid B, dankasterones A and dankasterone B were purified by a series of column chromatography. They showed significant cytotoxicity toward murine colorectal CT26 and human leukemia K562 cancer cell lines.
論文出處：Molecules. 2014 Feb 21;19(2):2546-56. doi: 10.3390/molecules19022546.
論文名稱：In vivo and in vitro anti-tumor effects of fungal extracts.
作 者：Wu HT, Lu FH, Su YC, Ou HY, Hung HC, Wu JS, Yang YC, Chang CJ
出 版 年：2014
分 類：抗癌
論文結論：Ethanol extracts of Taiwanofungus camphorates exert anti-cancer activities, and water extracts show lower inhibitory activities in vitro. Ethanol extract also decreased tumor size and increased the lifespan in mice bearing sarcoma-180 tumors.
論文出處：Evid Based Complement Alternat Med. 2014;2014:246748. doi: 10.1155/2014/246748. Epub 2014 Nov 6.
論文名稱：Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells.
作 者：Chung CH, Yeh SC, Chen CJ, Lee KT
出 版 年：2014
分 類：抗癌
論文結論：2,3-dimethoxy-5-methyl-1,4-benzoquinone (coenzyme Q0; CoQ0) derived from Antrodia cinnamomea submerged culture filtrates exerts its anticancer effect through the induction of ROS-mediated apoptosis in A549 human lung cancer cells.
論文出處：J Ethnopharmacol. 2013 Jun 21;148(1):254-65. doi: 10.1016/j.jep.2013.04.023. Epub 2013 Apr 22.
論文名稱：The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma (SKOV-3) cells via modulation of HER-2/neu signaling pathway.
作 者：Yang HL, Lin KY, Juan YC, Kumar KJ, Way TD, Shen PC, Chen SC, Hseu YC.
出 版 年：2013
分 類：抗癌
論文結論：Antrodia camphorata may exert anti-tumor activity against human ovarian carcinoma by suppressing HER-2/neu signaling pathways.
論文出處：Molecules. 2013 Feb 26;18(3):2539-48. doi: 10.3390/molecules18032539.
論文名稱：Methyl Antcinate A suppresses the population of cancer stem-like cells in MCF7 human breast cancer cell line.
作 者：Peng CY, Fong PC, Yu CC, Tsai WC, Tzeng YM, Chang WW.
出 版 年：2013
分 類：抗癌
論文結論：Methyl antcinate A (MAA) has anti-CSCs (Cancer stem cells) activity and is worthy of future development of potent anticancer agents.
論文出處：Carcinogenesis. 2013 Dec;34(12):2918-28. doi: 10.1093/carcin/bgt255. Epub 2013 Jul 23.
論文名稱：A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.
作 者：Yeh CT, Huang WC, Rao YK, Ye M, Lee WH, Wang LS, Tzeng DT, Wu CH, Shieh YS, Huang CY, Chen YJ, Hsiao M, Wu AT, Yang Z, Tzeng YM.
出 版 年：2013
分 類：抗癌
論文結論：Antrocin may be a potential therapeutic agent for human lung cancer cells (H441 and H1975) through constitutive inhibition of JAK2/STAT3 pathway.
論文出處：Evid Based Complement Alternat Med. 2013;2013:569737. doi: 10.1155/2013/569737. Epub 2013 Mar 6.
論文名稱：Medicinal Fungus Antrodia cinnamomea Inhibits Growth and Cancer Stem Cell Characteristics of Hepatocellular Carcinoma.
作 者：Liu YM, Liu YK, Lan KL, Lee YW, Tsai TH, Chen YJ.
出 版 年：2013
分 類：抗癌
論文結論：Mycelial fermentation broth of Antrodia cinnamomea (AC-MFB) could inhibit the growth of hepatocellular carcinoma (HCC) in murine 1MEA.7R.1 cells and human HA22T/VGH HCC cells. And inhibited the cellular viability, migration, and tube formation activity in cancer stem cells (EA. hy926 and SVEC4-10 endothelial cells).
論文出處：J Agric Food Chem. 2013 Sep 25;61(38):9160-5. doi: 10.1021/jf402187q. Epub 2013 Sep 10.
論文名稱：Enhancement of 4-acetylantroquinonol B production by supplementation of its precursor during submerged fermentation of Antrodia cinnamomea.
作 者：Chiang CC, Huang TN, Lin YW, Chen KH, Chiang BH.
出 版 年：2013
分 類：抗癌
論文結論：Oct-1-en-3-ol, linalool, methyl phenylacetate, nerolidol, γ-cadinene and 2,4,5-trimethoxybenzaldehyde (TMBA) are major volatile compounds of Antrodia cinnamomea. Used TMBA and nerolidol during fermentation, could increase the production of 4-acetylantroquinonol B and enhance the antiproliferation activity on hepatocellular cancer cells HepG2.
論文出處：Chin Med. 2013 Nov 1;8(1):21. doi: 10.1186/1749-8546-8-21.
論文名稱：Current evidence for the hepatoprotective activities of the medicinal mushroom Antrodia cinnamomea.
作 者：Yue PY, Wong YY, Wong KY, Tsoi YK, Leung KS.
出 版 年：2013
分 類：抗癌
論文結論：This review focuses on the inhibitory effects of Antrodia cinnamomea (AC) on hepatitis, hepatocarcinoma, and alcohol-induced liver diseases (e.g., fatty liver, fibrosis). The relevant biochemical and molecular mechanisms in vitro and in vivo are addressed.
論文出處：PLoS One. 2013 Dec 17;8(12):e82751. doi: 10.1371/journal.pone.0082751. eCollection 2013.
論文名稱：Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells.
作 者：Chen YJ, Thang MW, Chan YT, Huang YF, Ma N, Yu AL, Wu CY, Hu ML, Chiu KP
出 版 年：2013
分 類：抗癌
論文結論：Antrodia cinnamomea indiscriminately induced a global downregulation of miRNAs by simultaneously inhibiting the key enzymes involved in miRNA maturation and activating XRN2 protein involved in miRNA degradation in SK-Hep-1 cells. Collapsing of the miRNA system together with downregulation of cell growth and survival pathways and activation of JNK signaling unleash the extrinsic and intrinsic apoptosis pathways, leading to the cancer cell death.
論文出處：Evid Based Complement Alternat Med. 2013;2013:296082. doi: 10.1155/2013/296082. Epub 2013 Dec 11.
論文名稱：Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism.
作 者：Gokila Vani M, Kumar KJ, Liao JW, Chien SC, Mau JL, Chiang SS, Lin CC, Kuo YH, Wang SY.
出 版 年：2013
分 類：抗癌
論文結論：Antcin C, a steroid-like compound isolated from Antrodia cinnamomea, could protect liver cells from oxidative stress and cell death via Nrf2/ARE activation.
論文出處：Integr Cancer Ther. 2013 Mar;12(2):153-64. doi: 10.1177/1534735412442379. Epub 2012 Jul 12.
論文名稱：Taiwanofungus camphoratus (Syn Antrodia camphorata) extract and amphotericin B exert adjuvant effects via mitochondrial apoptotic pathway.
作 者：Chen LY, Sheu MT, Liao CK, Tsai FC, Kao WY, Su CH.
出 版 年：2013
分 類：抗癌
論文結論：Ethanol extract of solid-state cultivated Taiwanofungus camphoratus (TCEE) and Amphotericin B (AmB) enhanced cell cycle arrest and apoptosis. The antitumor efficacy may be mediated by alterations in the levels of key proteins that regulate the cell cycle and apoptosis. Our results indicate the novel possibility that the drug combination of a conventional antifungal agent and a traditional Chinese medicine may serve as an alternative medicine for patients suffering from malignancies.
論文出處：J Med Food. 2013 Aug;16(8):681-91. doi: 10.1089/jmf.2012.2605.
論文名稱：Antrodia camphorata grown on germinated brown rice inhibits HT-29 human colon carcinoma proliferation through inducing G0/G1 phase arrest and apoptosis by targeting the β-catenin signaling.
作 者：Park DK, Lim YH, Park HJ.
出 版 年：2013
分 類：抗癌
論文結論：Antrodia camphorata grown on germinated brown rice (CBR) EtOAc fraction showed the strongest inhibitory activity against HT-29 human colon cancer cell and CT-26 human rectum cancer cell proliferation.
論文出處：Curr Top Med Chem. 2013;13(21):2791-806.
論文名稱：Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action.
作 者：Popović V, Živković J, Davidović S, Stevanović M, Stojković D.
出 版 年：2013
分 類：抗癌
論文結論：The Antrodia camphorata and Ganoderma lucidium extracts and isolated bioactive compounds reporting the heteropolysaccharides, β-glucans, α-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review.
論文出處：Am J Chin Med. 2013;41(5):1169-80. doi: 10.1142/S0192415X13500791.
論文名稱：Cytotoxic effect and induction of apoptosis in human cervical cancer cells by Antrodia camphorata.
作 者：Yang PY, Hu DN, Liu FS.
出 版 年：2013
分 類：抗癌
論文結論：The crude extract of Antrodia camphorata is cytotoxic to cervical cancer cells (HeLa and C-33A) through apoptotic mechanisms.
論文出處：J Nutr Biochem. 2012 Aug;23(8):900-7. doi: 10.1016/j.jnutbio.2011.04.015. Epub 2011 Aug 12.
論文名稱：Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.
作 者：Yu CC, Chiang PC, Lu PH, Kuo MT, Wen WC, Chen P, Guh JH.
出 版 年：2012
分 類：抗癌
論文結論：Antroquinonol, a ubiquinone derivative isolated from Antrodia camphorata, induced the inhibition of cell proliferation in pancreatic cancer PANC-1 and AsPC-1 cells. Induced G1 arrest of the cell cycle and a subsequent apoptosis.
論文出處：Evid Based Complement Alternat Med. 2012;2012:702857. doi: 10.1155/2012/702857. Epub 2012 Jun 3.
論文名稱：Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.
作 者：Lee CC, Yang HL, Way TD, Kumar KJ, Juan YC, Cho HJ, Lin KY, Hsu LS, Chen SC, Hseu YC.
出 版 年：2012
分 類：抗癌
論文結論：The anticancer activity of Antrodia camphorata (AC) against human HER-2/neu-overexpressing breast cancers.
論文出處：Eur J Pharmacol. 2012 Apr 5;680(1-3):8-15. doi: 10.1016/j.ejphar.2012.01.032. Epub 2012 Feb 10.
論文名稱：Inhibition of cell survival, cell cycle progression, tumor growth and cyclooxygenase-2 activity in MDA-MB-231 breast cancer cells by camphorataimide B.
作 者：Lin WL, Lee YJ, Wang SM, Huang PY, Tseng TH.
出 版 年：2012
分 類：抗癌
論文結論：Camphorataimide B (isolated from mycelium of Antrodia camphorate) decreased the cell viability, triggered apoptosis and blocked cell cycle progression of MDA-MB-231 breast cancer cells.
論文出處：J Agric Food Chem. 2012 Apr 11;60(14):3612-8. doi: 10.1021/jf300221g. Epub 2012 Mar 29.
論文名稱：In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from the fruiting body of Antrodia camphorata through activation of the p53-mediated p27/Kip1 signaling pathway.
作 者：Tu SH, Wu CH, Chen LC, Huang CS, Chang HW, Chang CH, Lien HM, Ho YS.
出 版 年：2012
分 類：抗癌
論文結論：4,7-dimethoxy-5-methyl-1,3-benzodioxole (SY-1) was isolated from Antrodia camphorata (AC) fruiting bodies. That SY-1 profoundly decreased the growth of COLO-205 human colon cancer cell tumor xenografts in an athymic nude mouse model.
論文出處：J Cancer Res Ther. 2012 Oct-Dec;8(4):532-6. doi: 10.4103/0973-1482.106529.
論文名稱：The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate.
作 者：Wei PL, Tu SH, Lien HM, Chen LC, Chen CS, Wu CH, Huang CS, Chang HW, Chang CH, Tseng H, Ho YS.
出 版 年：2012
分 類：抗癌
論文結論：4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) is a chemical derivative of 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1), SY-1 has been isolated from dried Antrodia camphorata fruiting bodies. The antitumor effects of apiole against colon tumors in an in vivo xenograft model.
論文出處：Evid Based Complement Alternat Med. 2012;2012:378415. doi: 10.1155/2012/378415. Epub 2012 Feb 21.
論文名稱：Ethanol extracts of fruiting bodies of Antrodia cinnamomea suppress CL1-5 human lung adenocarcinoma cells migration by inhibiting matrix metalloproteinase-2/9 through ERK, JNK, p38, and PI3K/Akt signaling pathways.
作 者：Chen YY, Liu FC, Chou PY, Chien YC, Chang WS, Huang GJ, Wu CH, Sheu MJ.
出 版 年：2012
分 類：抗癌
論文結論：Ethanol extract of fruiting bodies of Antrodia cinnamomea (EEAC) induced FAK phosphorylation and exhibited its antimigration activities via the PI3K/AKT and MAPK signalings in CL1-5 cells.
論文出處：Phytomedicine. 2012 Jun 15;19(8-9):768-78. doi: 10.1016/j.phymed.2012.02.016. Epub 2012 Mar 29.
論文名稱：Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways.
作 者：Chen YY, Chou PY, Chien YC, Wu CH, Wu TS, Sheu MJ.
出 版 年：2012
分 類：抗癌
論文結論：Ethanol extract of fruiting bodies of Antrodia cinnamomea (EEAC) exerted inhibitory effect on migration and motility in CL1-0 cells.
論文出處：J Tradit Complement Med. 2012 Oct;2(4):284-94.
論文名稱：Protective effects of Antrodia cinnamomea against liver injury.
作 者：Liu YW, Lu KH, Ho CT, Sheen LY
出 版 年：2012
分 類：抗癌
論文結論：The potential application of Antrodia cinnamomea in preventing and treating liver diseases and its potential to be developed into health foods or new drugs.
論文出處：J Tradit Complement Med. 2012 Oct;2(4):312-22.
論文名稱：Eburicoic Acid, an Active Triterpenoid from the Fruiting Bodies of Basswood Cultivated Antrodia cinnamomea, Induces ER Stress-Mediated Autophagy in Human Hepatoma Cells.
作 者：Su YC, Liu CT, Chu YL, Raghu R, Kuo YH, Sheen LY
出 版 年：2012
分 類：抗癌
論文結論：Eburicoic acid, the second most abundant triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, has significant anti-liver cancer effects and more distinctive mechanisms.
論文出處：Phytomedicine. 2012 Jun 15;19(8-9):788-96. doi: 10.1016/j.phymed.2012.03.014. Epub 2012 Apr 18.
論文名稱：Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models.
作 者：Du YC, Chang FR, Wu TY, Hsu YM, El-Shazly M, Chen CF, Sung PJ, Lin YY, Lin YH, Wu YC, Lu MC.
出 版 年：2012
分 類：抗癌
論文結論：Five triterpenoids, antcin K, antcin C, zhankuic acid C, zhankuic acid A, and dehydroeburicoic acid (DeEA) were isolated from triterpenoid-rich fraction (FEA) of ethanolic extract of Antrodia camphorata and characterized by high performance liquid chromatography (HPLC). The dehydroeburicoic acid (DeEA) was the most potent cytotoxic component. Activated DNA damage and apoptosis biomarkers similar to FEA.
論文出處：Anticancer Res. 2012 Jul;32(7):2727-34.
論文名稱：Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.
作 者：Lee YP, Tsai WC, Ko CJ, Rao YK, Yang CR, Chen DR, Yang MH, Yang CC, Tzeng YM.
出 版 年：2012
分 類：抗癌
論文結論：These triterpenoids (methyl antcinate A, methyl antcinate B, dehydroeburicoic acid, and 15α-acetyl-dehydrosulfurenic acid) may lead to the development of more potent anticancer drugs.
論文出處：Phytochemistry. 2012 Dec;84:177-83. doi: 10.1016/j.phytochem.2012.08.011. Epub 2012 Sep 18.
論文名稱：Lanostane triterpenoids and sterols from Antrodia camphorata.
作 者：Huang HC, Liaw CC, Yang HL, Hseu YC, Kuo HT, Tsai YC, Chien SC, Amagaya S, Chen YC, Kuo YH.
出 版 年：2012
分 類：抗癌
論文結論：Four lanostane triterpenes (3,7,11-trioxo-5α-lanosta-8,24(E)-dien-26-oic acid, methyl 11α-3,7-dioxo-5α-lanosta-8,24(E)-dien-26-oate, methyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, and ethyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate) and two sterols (camphosterol A and (14α,22E)-14-hydroxyergosta-7,22-diene-3,6-dione) were isolated from a mixture of fruiting bodies and mycelia of Antrodia camphorata. Six compounds were have activity for cytotoxicity against human tumor cell lines.
論文出處：J Nat Prod. 2012 Nov 26;75(11):2016-44. doi: 10.1021/np300412h. Epub 2012 Oct 23.
論文名稱：Lanostanoids from fungi: a group of potential anticancer compounds.
作 者：Ríos JL, Andújar I, Recio MC, Giner RM.
出 版 年：2012
分 類：抗癌
論文結論：This review showed that lanostanes are a group of tetracyclic triterpenoids derived from lanosterol. They have great potential as anticancer agents because of their cytotoxic or apoptotic effects. To arrest the cell cycle in the G1 phase, increase levels of p53 and Bax, or inhibit the phosphorylation of Erk1/2 or the activation of NF-κB and AP-1. Have inhibitory effects on the growth of androgen prostate carcinoma through increasing the expression of p21, which activates the tumor suppressor protein p53.
論文出處：Int J Gynecol Cancer. 2011 Oct;21(7):1172-9. doi: 10.1097/IGC.0b013e31821f742c.
論文名稱：Antrodia camphorata induces apoptosis and enhances the cytotoxic effect of paclitaxel in human ovarian cancer cells.
作 者：Liu FS, Yang PY, Hu DN, Huang YW, Chen MJ.
出 版 年：2011
分 類：抗癌
論文結論：Crude extract of Antrodia camphorata causes a cytotoxic effect on ovarian cancer cells through the induction of apoptosis. It may also enhance the antitumor effect of paclitaxel.
論文出處：Food Chem Toxicol. 2011 Jan;49(1):290-8. doi: 10.1016/j.fct.2010.10.031. Epub 2010 Nov 4.
論文名稱：Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway.
作 者：Yang HL, Kuo YH, Tsai CT, Huang YT, Chen SC, Chang HW, Lin E, Lin WH, Hseu YC.
出 版 年：2011
分 類：抗癌
論文結論：Antrodia camphorata markedly inhibited the invasion/migration of highly metastatic MDA-MB-231 cells as shown by an in vitro transwell and a wound-healing repair assay.
論文出處：Chem Res Toxicol. 2011 Feb 18;24(2):238-45. doi: 10.1021/tx100318m. Epub 2010 Dec 15.
論文名稱：Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells.
作 者：Rao YK, Wu AT, Geethangili M, Huang MT, Chao WJ, Wu CH, Deng WP, Yeh CT, Tzeng YM
出 版 年：2011
分 類：抗癌
論文結論：Antrocin, isolated from Antrodia camphorata, as an Akt/mTOR dual inhibitor for the treatment of metastatic breast cancer MDA-MB-231 cells (MMCs).
論文出處：Evid Based Complement Alternat Med. 2011;2011:450529. doi: 10.1093/ecam/nep230. Epub 2011 May 3.
論文名稱：Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells.
作 者：Lien HM, Kuo PT, Huang CL, Kao JY, Lin H, Yang DY, Lai YY.
出 版 年：2011
分 類：抗癌
論文結論：SY-1 (4,7-dimethoxy-5-methyl-l,3-benzodioxole) was isolated from Antrodia camphorata, and the analogue “apiole”(5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole) decreased the proliferation of human colorectal carcinoma cancer cells (COLO 205).
論文出處：J Agric Food Chem. 2011 Oct 26;59(20):11255-63. doi: 10.1021/jf2024215. Epub 2011 Sep 25.
論文名稱：Pretreatment with an ethanolic extract of Taiwanofungus camphoratus (Antrodia camphorata) enhances the cytotoxic effects of amphotericin B.
作 者：Chen LY, Sheu MT, Liu DZ, Liao CK, Ho HO, Kao WY, Ho YS, Lee WS, Su CH.
出 版 年：2011
分 類：抗癌
論文結論：Combined treatment with amphotericin B (AmB) and ethanolic extract of Taiwanofungus camphoratus (TCEE) effectively induced apoptosis and inhibited tumor growth.
論文出處：Evid Based Complement Alternat Med. 2011;2011:984027. doi: 10.1093/ecam/nep020. Epub 2011 Jun 8.
論文名稱：Inhibition of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle Regulation in Human Colorectal Carcinoma Cells by 4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole Isolated from the Fruiting Body of Antrodia camphorate.
作 者：Lien HM, Lin HW, Wang YJ, Chen LC, Yang DY, Lai YY, Ho YS
出 版 年：2011
分 類：抗癌
論文結論：4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) was isolated from three different sources of dried fruiting bodies of Antrodia camphorate (AC). That inhibits human colon cancer cell (COLO 205) proliferation through inhibition of cell growth and anchorage-independent colony formation in soft agar.
論文出處：Evid Based Complement Alternat Med. 2011;2011:750230. doi: 10.1155/2011/750230. Epub 2011 Mar 9.
論文名稱：Apoptotic Cell Death and Inhibition of Wnt/β-Catenin Signaling Pathway in Human Colon Cancer Cells by an Active Fraction (HS7) from Taiwanofungus camphoratus.
作 者：Yeh CT, Yao CJ, Yan JL, Chuang SE, Lee LM, Chen CM, Yeh CF, Li CH, Lai GM.
出 版 年：2011
分 類：抗癌
論文結論：HS7, an active fraction extracted from Taiwanofungus camphoratus, significantly inhibited proliferation of HT29, HCT116, and SW480 colon cancer cells.
論文出處：Mutat Res. 2011 Feb 10;707(1-2):42-52. doi: 10.1016/j.mrfmmm.2010.12.009. Epub 2010 Dec 24.
論文名稱：Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles.
作 者：Kumar VB, Yuan TC, Liou JW, Yang CJ, Sung PJ, Weng CF.
出 版 年：2011
分 類：抗癌
論文結論：Antroquinonol treatment significantly reduced the proliferation of NSCLC cells, increased cell shrinkage, apoptotic vacuoles, pore formation, and increased Sub-G1 cell population.
論文出處：Evid Based Complement Alternat Med. 2011;2011:914561. doi: 10.1093/ecam/nep228. Epub 2011 Mar 13.
論文名稱：A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging.
作 者：Chiou JF, Wu AT, Wang WT, Kuo TH, Gelovani JG, Lin IH, Wu CH, Chiu WT, Deng WP.
出 版 年：2011
分 類：抗癌
論文結論：Antrodia camphorata alcohol extract (ACAE) contains anti-cancer properties and could be considered as a potential CAM agent in future clinical evaluation.
論文出處：J Agric Food Chem. 2011 Oct 26;59(20):10943-54. doi: 10.1021/jf202771d. Epub 2011 Oct 5.
論文名稱：Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway.
作 者：Hsieh YC, Rao YK, Whang-Peng J, Huang CY, Shyue SK, Hsu SL, Tzeng YM.
出 版 年：2011
分 類：抗癌
論文結論：The triterpenoids, methylantcinate B (MAB) and antcin B (AB), isolated from Antrodia camphorata, induced apoptosis in HepG2 cells, as characterized by increased DNA fragmentation, cleavage of PARP, sub-G1 population, chromatin condensation, loss of mitochondrial membrane potential, and release of cytochrome c.
論文出處：J Ethnopharmacol. 2011 Jun 14;136(1):168-77. doi: 10.1016/j.jep.2011.04.030. Epub 2011 Apr 20.
論文名稱：Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.
作 者：Kumar KJ, Chu FH, Hsieh HW, Liao JW, Li WH, Lin JC, Shaw JF, Wang SY
出 版 年：2011
分 類：抗癌
論文結論：Ethanolic extracts of mycelia of Antrodia cinnamomea (EMAC) and Antroquinonol, a potent bioactive compound from Antrodia cinnamomea, may be responsible for the hepatoprotective activity.
論文出處：J Agric Food Chem. 2011 Aug 24;59(16):8625-31. doi: 10.1021/jf2011326. Epub 2011 Jul 26.
論文名稱：4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels.
作 者：Lin YW, Chiang BH.
出 版 年：2011
分 類：抗癌
論文結論：4-acetylantroquinonol B, isolated from the mycelium of Antrodia cinnamomea, inhibits proliferation of HepG2 cells via affecting p53, p21 and p27 proteins, CDK2 and CDK4 proteins downregulations. The proportion of cells in the G1 phase of the cell cycle increased and that in the S phase decreased significantly, and the proportion of G2/M phase cells were not obviously changed.
論文出處：Evid Based Complement Alternat Med. 2011;2011:212641. doi: 10.1093/ecam/nep108. Epub 2011 Jan 3.
論文名稱：Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds
作 者：Geethangili M, Tzeng YM
出 版 年：2011
分 類：抗癌
論文結論：Antrodia camphorata can be considered as an efficient alternative phytotherapeutic agent or a synergizer in the treatment of cancer and other immune-related diseases. And the next step is to produce some medicines from Antrodia camphorata, however, the production may be hampered by problems related to mass production.
論文出處：Bioorg Med Chem Lett. 2010 Oct 15;20(20):6145-8. doi: 10.1016/j.bmcl.2010.08.006. Epub 2010 Aug 6.
論文名稱：Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway.
作 者：Tsai WC, Rao YK, Lin SS, Chou MY, Shen YT, Wu CH, Geethangili M, Yang CC, Tzeng YM.
出 版 年：2010
分 類：抗癌
論文結論：An ergostane type triterpenoid, methylantcinate A (MAA), was isolated from the fruiting bodies of Antrodia camphorata. That inhibited the growth of oral cancer cell lines (OEC-M1 and OC-2).
論文出處：Int Urol Nephrol. 2010 Sep;42(3):637-45. doi: 10.1007/s11255-009-9642-x. Epub 2009 Sep 17.
論文名稱：Protective effect of Antrodia camphorata on bladder ischemia/reperfusion injury.
作 者：Juan YS, Mannikarottu A, Chuang SM, Li S, Lin AD, Chang-Chou L, Schuler C, Leggett RE, Levin RM.
出 版 年：2010
分 類：抗癌
論文結論：Ischemia/Reperfusion (I/R) injury resulted in decreased compliance, decreased contractile responses, decreased nerve density, and increased apoptosis. Antrodia Camphorata pretreatment of rabbits were protected the bladder from all contractile, biochemical, and structural dysfunctions resulting in significantly improved bladder.
論文出處：J Ethnopharmacol. 2010 Feb 17;127(3):652-61. doi: 10.1016/j.jep.2009.12.008. Epub 2009 Dec 6.
論文名稱：Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell.
作 者：Chan YY, Chang CS, Chien LH, Wu TF
出 版 年：2010
分 類：抗癌
論文結論：The anti-cancer activity of Antrodia camphorata might be due to multiple active metabolites, which work together to induce cell apoptosis via various pathways.
論文出處：Chem Res Toxicol. 2010 Jul 19;23(7):1256-67. doi: 10.1021/tx100116a.
論文名稱：Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.
作 者：Hsieh YC, Rao YK, Wu CC, Huang CY, Geethangili M, Hsu SL, Tzeng YM.
出 版 年：2010
分 類：抗癌
論文結論：Antcin A, antcin C, and methyl antcinate A (MAA) were isolated from Antrodia camphorata. That inhibit the proliferation of human liver cancer cell lines Huh7, HepG2, and Hep3B. The compound MAA was a more potent cytotoxic agent than antcins A and C.
論文出處：Biochem Pharmacol. 2010 Jan 15;79(2):162-71. doi: 10.1016/j.bcp.2009.08.022. Epub 2009 Aug 31.
論文名稱：Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.
作 者：Chiang PC, Lin SC, Pan SL, Kuo CH, Tsai IL, Kuo MT, Wen WC, Chen P, Guh JH
出 版 年：2010
分 類：抗癌
論文結論：Antroquinonol (isolated from Antrodia camphorate) displays anticancer activity against HCCs through AMPK activation and inhibition of mTOR translational pathway, leading to G1 arrest of the cell-cycle and subsequent cell apoptosis.
論文出處：J Sci Food Agric. 2010 Aug 15;90(10):1739-44. doi: 10.1002/jsfa.4010.
論文名稱：The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells.
作 者：Lin YW, Pan JH, Liu RH, Kuo YH, Sheen LY, Chiang BH.
出 版 年：2010
分 類：抗癌
論文結論：4-Acetylantroquinonol B, a major antihepatoma compound in HepG2 cells, was isolate from the submerged fermentation mycelium of Antrodia cinnamomea.
論文出處：Chin J Physiol. 2009 Jun 30;52(3):128-35.
論文名稱：Effects of Antrodia camphorata extracts on the viability, apoptosis, [Ca2+]i, and MAPKs phosphorylation of OC2 human oral cancer cells.
作 者：Huang CC, Cheng HH, Wang JL, Cheng JS, Chai KL, Fang YC, Kuo CC, Chu ST, Ho CM, Lin KL, Tsai JY, Jan CR
出 版 年：2009
分 類：抗癌
論文結論：Antrodia camphorata exerted multiple effects on their viability and [Ca2+]i, induced their ERK and JNK MAPK phosphorylation, and probably evoked their apoptosis.
論文出處：Cancer Lett. 2009 Nov 18;285(1):73-9. doi: 10.1016/j.canlet.2009.05.002. Epub 2009 May 23.
論文名稱：Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells.
作 者：Yeh CT, Rao YK, Yao CJ, Yeh CF, Li CH, Chuang SE, Luong JH, Lai GM, Tzeng YM
出 版 年：2009
分 類：抗癌
論文結論：Five lanostane (2, 3, 4, 6 and 8) and three ergostane-type (1, 5 and 7) triterpenes isolated from the fruiting bodies of Antrodia camphorata. The three zhankuic acids, 1, 5 and 7 displayed the most potent cytotoxic effect. Induce apoptosis in HT-29 and SW-480 cells, as confirmed by sub-G1 cell cycle arrest. (The expression of apoptosis-associated proteins poly-(ADP-ribose) polymerase cleavage, Bcl-2 and procaspase-3 were suppressed.)
論文出處：J Ethnopharmacol. 2009 Jan 21;121(2):194-212. doi: 10.1016/j.jep.2008.10.039. Epub 2008 Nov 17.
論文名稱：Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases.
作 者：Ao ZH1, Xu ZH, Lu ZM, Xu HY, Zhang XM, Dou WF
出 版 年：2009
分 類：抗癌
論文結論：This review will address the protective effects of Niuchangchih on the pathological development of liver diseases, and the underlying mechanisms of action are also discussed.
論文出處：Am J Chin Med. 2009;37(4):771-83.
論文名稱：The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells.
作 者：Li SL, Huang ZN, Hsieh HH, Yu WC, Tzeng WY, Lee GY, Chen YP, Chang CY, Chuu JJ.
出 版 年：2009
分 類：抗癌
論文結論：A novel strategy of fermenting Antrodia camphorata with Chinese medicinal herb (AC-CF), which augmented their anti-tumor effects in human hepatoma HepG2 cells as compared with two other traditional ones. (Extracts from fruiting bodies , AC-FB, or solid-state culture, AC-SS, of Antrodia camphorata.)
論文出處：Arch Toxicol. 2009 Feb;83(2):121-9. doi: 10.1007/s00204-008-0337-3. Epub 2008 Aug 16.
論文名稱：Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A.
作 者：Lu MC, Du YC, Chuu JJ, Hwang SL, Hsieh PC, Hung CS, Chang FR, Wu YC
出 版 年：2009
分 類：抗癌
論文結論：Ethanol extract from wild fruiting bodies of Antrodia camphorata (EEAC) could induce HL 60 cells apoptosis via histone hypoacetylation, up-regulation of histone deacetyltransferase 1 (HDAC 1), and down-regulation of histone acetyltransferase activities including GCN 5, CBP and PCAF. Combined treatment with histone deacetylase inhibitor, trichostatin A (TSA) caused synergistic inhibition of cell growth and increase of apoptotic induction. EEAC may be a potential chemotherapeutic adjuvant.
論文出處：Toxicol In Vitro. 2009 Apr;23(3):418-24. doi: 10.1016/j.tiv.2009.01.011. Epub 2009 Jan 22.
論文名稱：Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells.
作 者：Chen YJ, Chou CJ, Chang TT.
出 版 年：2009
分 類：抗癌
論文結論：MMH01, isolated from Antrodia cinnamomea, markedly inhibited growth of human leukemia U937 and pancreatic cancer BxPC3 cells.
論文出處：Chin J Physiol. 2008 Apr 30;51(2):78-84.
論文名稱：Effects of antrodia camphorata on viability, apoptosis, and [Ca2+]i in PC3 human prostate cancer cells.
作 者：Ho CM, Huang CC, Huang CJ, Cheng JS, Chen IS, Tsai JY, Jiann BP, Tseng PL, Kuo SJ, Jan CR.
出 版 年：2008
分 類：抗癌
論文結論：In human prostate cancer cells (PC3), Antrodia camphorata exerted multiple effects on viability and [Ca2+]i, caused apoptosis via pathways unrelated to [Ca2+]i signal and phosphorylation of ERK, JNK and p38 MAPKs.
論文出處：Food Chem Toxicol. 2008 Aug;46(8):2680-8. doi: 10.1016/j.fct.2008.04.036. Epub 2008 May 4.
論文名稱：Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo.
作 者：Hseu YC, Chen SC, Chen HC, Liao JW, Yang HL.
出 版 年：2008
分 類：抗癌
論文結論：Antrodia camphorata treatment induced cell cycle arrest and apoptosis of human breast cancer cells both in vitro and in vivo.
論文出處：J Ethnopharmacol. 2008 Aug 13;118(3):387-95. doi: 10.1016/j.jep.2008.05.001. Epub 2008 May 7.
論文名稱：The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells.
作 者：Chang CY, Huang ZN, Yu HH, Chang LH, Li SL, Chen YP, Lee KY, Chuu JJ.
出 版 年：2008
分 類：抗癌
論文結論：Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on hepatoma cells (in vitro) and on xenografted cells in tumor-implanted nude mice (in vivo).
論文出處：Biosci Biotechnol Biochem. 2008 Jul;72(7):1704-13. Epub 2008 Jul 7.
論文名稱：Taiwanofungus camphoratus activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats.
作 者：Suk FM, Lin SY, Chen CH, Yen SJ, Su CH, Liu DZ, Hou WC, Hung LF, Lin PJ, Liang YC.
出 版 年：2008
分 類：抗癌
論文結論：Taiwanofungus camphoratus might contain PPARgamma ligands and result in a hypotriglyceridemic effect, and that it also exhibits a liver protective activity in SD rats.
論文出處：J Food Sci. 2008 Sep;73(7):H179-85. doi: 10.1111/j.1750-3841.2008.00884.x. Epub 2008 Aug 18.
論文名稱：Ethanolic extracts of Antrodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes.
作 者：Chen YS, Pan JH, Chiang BH, Lu FJ, Sheen LY.
出 版 年：2008
分 類：抗癌
論文結論：Ethanolic extracts from mycelia of Antrodia cinnamomea (AC) possessed high antihepatoma activity against Hep3B and HepG2 cells in rat.
論文出處：Nutr Cancer. 2007;57(1):111-21.
論文名稱：Unique formosan mushroom Antrodia camphorata differentially inhibits androgen-responsive LNCaP and -independent PC-3 prostate cancer cells.
作 者：Chen KC, Peng CC, Peng RY, Su CH, Chiang HS, Yan JH, Hsieh-Li HM
出 版 年：2007
分 類：抗癌
論文結論：Antrodia camphorata crude extract (ACCE) is able to differentially inhibit the growth of different prostate cancer cells by modulating different cell cycle signaling pathways.
論文出處：J Ethnopharmacol. 2007 Jan 3;109(1):93-103. Epub 2006 Jul 11.
論文名稱：Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells.
作 者：Peng CC, Chen KC, Peng RY, Chyau CC, Su CH, Hsieh-Li HM.
出 版 年：2007
分 類：抗癌
論文結論：Antrodia camphorata crude extract (ACCE) can be rather effective and beneficial in suppression of both the superficial cancer cell line RT4 and the metastatic cell lines (TSGH-8301 and T24) through different mechanisms.
論文出處：Food Chem Toxicol. 2007 Jul;45(7):1107-15. Epub 2006 Dec 27.
論文名稱：Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata.
作 者：Hseu YC, Chen SC, Tsai PC, Chen CS, Lu FJ, Chang NW, Yang HL.
出 版 年：2007
分 類：抗癌
論文結論：Antrodia camphorata exerts growth inhibition on highly invasive estrogen-nonresponsive (MDA-MB-231) human breast cancer cells through apoptosis induction associated with COX-2 inhibition, and it possessed anticancer properties.
論文出處：Food Chem Toxicol. 2007 Jul;45(7):1249-57. Epub 2007 Jan 17.
論文名稱：Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway.
作 者：Hsu YL, Kuo PL, Cho CY, Ni WC, Tzeng TF, Ng LT, Kuo YH, Lin CC.
出 版 年：2007
分 類：抗癌
論文結論：Ethylacetate extract from fruiting bodies of Antrodia cinnamomea (EAC) treatment decreased the cancer invasion of PLC/PRF/5 cells.
論文出處：J Ethnopharmacol. 2007 Oct 8;114(1):78-85. Epub 2007 Aug 2.
論文名稱：Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts.
作 者：Rao YK, Fang SH, Tzeng YM
出 版 年：2007
分 類：抗癌
論文結論：The anti-inflammatory and anti-cancer properties of Antrodia camphorata might result from the growth inhibition of NO, TNF-alpha and IL-12, and tumor cells proliferation
論文出處：Planta Med. 2007 Oct;73(13):1412-5. Epub 2007 Oct 11.
論文名稱：A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.
作 者：Lee TH, Lee CK, Tsou WL, Liu SY, Kuo MT, Wen WC
出 版 年：2007
分 類：抗癌
論文結論：Antroquinonol, an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata. That have cytotoxic activities of MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines.
論文出處：Cancer Lett. 2006 Nov 8;243(1):109-19. Epub 2006 Feb 7
論文名稱：Human urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata extracts.
作 者：Peng CC, Chen KC, Peng RY, Su CH, Hsieh-Li HM
出 版 年：2006
分 類：抗癌
論文結論：Antrodia camphorata extracts, ACCE, is a good anti-cancer agent, being effective in inducing phase G(2)M arrest, acting as an anti-proliferative, and an anti-metastatic agent against bladder cancer cell T24 cells.
論文出處：Cancer Lett. 2006 Jan 18;231(2):215-27.
論文名稱：Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata.
作 者：Yang HL, Chen CS, Chang WH, Lu FJ, Lai YC, Chen CC, Hseu TH, Kuo CT, Hseu YC
出 版 年：2006
分 類：抗癌
論文結論：Antrodia camphorata exerts antiproliferative action and growth inhibition on MCF-7 cells through apoptosis induction
論文出處：Proteomics. 2006 Feb;6(3):826-35.
論文名稱：Proteomic analysis of the effect of Antrodia camphorata extract on human lung cancer A549 cell.
作 者：Wu H, Pan CL, Yao YC, Chang SS, Li SL, Wu TF
出 版 年：2006
分 類：抗癌
論文結論：Ethanol extracts of Antrodia camphorata cultivated by solid-state fermentation, SACE, might trigger the apoptosis in the A549 cells by inducing endoplasmic reticulum stress.
論文出處：Food Chem Toxicol. 2006 Aug;44(8):1316-26. Epub 2006 Feb 28.
論文名稱：Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells.
作 者：Kuo PL, Hsu YL, Cho CY, Ng LT, Kuo YH, Lin CC.
出 版 年：2006
分 類：抗癌
論文結論：Ethylacetate extract of fruiting bodies from Antrodia cinnamomea (EAC) decreased cell proliferation of Hep 3B cells by inducing apoptotic cell death.
論文出處：Cancer Lett. 2005 Apr 18;221(1):77-89.
論文名稱：Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines.
作 者：Hsu YL, Kuo YC, Kuo PL, Ng LT, Kuo YH, Lin CC
出 版 年：2005
分 類：抗癌
論文結論：EAC, ethylacetate extract from A. camphorata fruiting bodies, decreased the cell growth and induced apoptosis both in two human liver cancer cell lines (Hep G2 and PLC/PRF/5 cells).
論文出處：J Ethnopharmacol. 2005 Aug 22;100(1-2):158-67.
論文名稱：Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture.
作 者：Song TY, Hsu SL, Yen GC
出 版 年：2005
分 類：抗癌
論文結論：MEM, methanolic extracts of mycelia from Antrodia camphorata, induced HepG2 apoptosis through activation of caspase-3 and -8 cascades and regulation of the cell cycle progression to inhibit hepatoma cells proliferation.
論文出處：J Agric Food Chem. 2005 Jul 13;53(14):5559-64.
論文名稱：Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway.
作 者：Song TY, Hsu SL, Yeh CT, Yen GC
出 版 年：2005
分 類：抗癌
論文結論：MEM, methanol extracts of mycelia from Antrodia camphorata, induces HepG2 apoptosis through inhibition of cell growth and up-regulation of Fas/FasL to activate the pathway of caspase-3 and -8 cascades.
論文出處：J Nat Prod. 2004 Jan;67(1):46-8
論文名稱：Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line.
作 者：Nakamura N, Hirakawa A, Gao JJ, Kakuda H, Shiro M, Komatsu Y, Sheu CC, Hattori M
出 版 年：2004
分 類：抗癌
論文結論：Five new maleic and succinic acid derivatives were isolated from the mycelium of Antrodia camphorata. And they appreciable cytotoxic activity against LLC cells.
論文出處：Toxicol Appl Pharmacol. 2004 Dec 1;201(2):186-93
論文名稱：Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action.
作 者：Liu JJ, Huang TS, Hsu ML, Chen CC, Lin WS, Lu FJ, Chang WH
出 版 年：2004
分 類：抗癌
論文結論：A unique polysaccharide component from Antrodia camphorata mycelia (AC-PS), elicit its anti-tumor effect by promoting a Th1-dominant state and killer activities.