論文出處：Biomed Pharmacother. 2021 Jun;138:111504. doi:10.1016/j.biopha.2021.111504.
論文名稱：4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation.
作 者：Yen IC, Tu QW, Chang TC, Lin PH, Li YF, Lee SY.
出 版 年：2021
分 類：抗發炎
論文結論：
Objective
Nonalcoholic fatty liver disease (NAFLD) is an inflammatory lipotoxic disorder with a prevalence of over 25% worldwide. However, safe and effective therapeutic agents for the management of NAFLD are still lacking. We aimed to investigate the hepatoprotective effect and molecular mechanism of 4-acetylantroquinonol B (4-AAQB), a natural ubiquinone derivative obtained from the mycelia of Antrodia cinnamomea.
Methods
RAW264.7 and J774A.1 cells were treated with 4-AAQB and then stimulated with LPS or tunicamycin (TM) for 24 h. Inflammatory responses, markers of endoplasmic reticulum (ER) stress, and NOD-like receptor protein 3 (NLRP3) inflammasome were analyzed in both cell lines. In the applied in vivo model, male C57BL/6J mice were fed with chow or a methionine/choline-deficient (MCD) diet along with vehicle or 4-AAQB (10 mg/kg, i.p. injected, once a day) for 10 consecutive days. Plasma levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured. Liver tissues were analyzed using histological techniques; protein levels involved in ER stress, NLRP3 inflammasome, and inflammatory responses were measured.
Results
4-AAQB significantly ameliorated the plasma levels of ALT and AST as well as the NAFLD activity score (NAS) in mice fed the MCD diet. In addition, 4-AAQB suppressed inflammatory responses, ER stress, and NLRP3 inflammasome activation, but increased the nuclear factor erythroid 2-related factor 2 (Nrf2) and Sirtuin 1 (SIRT1) signaling pathways in both in vitro and in vivo models.
Conclusions
We suggest that 4-AAQB treatment might be a tangible therapeutic strategy in the management of NAFLD/NASH.
論文出處：J Am Coll Nutr. 2021 May-Jun;40(4):349-357. doi:10.1080/07315724.2020.1779850.
論文名稱：Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
作 者：Chiou YL, Chyau CC, Li TJ, Kuo CF, Kang YY, Chen CC, Ko WS.
出 版 年：2021
分 類：抗發炎
論文結論：Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary society because of the changing dieting styles. Complicated syndromes often accompanied by obesity and diabetes makes no standard treatment for NASH. Therefore, we investigated the potential role of Antrodia cinnamomea mycelium (ACM) as nutraceutical supplementation in the treatment of NASH in this 6-month randomized, double-blind, placebo-controlled study.
Method
28 Participants were treated with three capsules per day containing either 420 mg of ACM or 420 mg of starch as a placebo. The participants were required to follow a predetermined regular visit to hospital every three months during the intervention period (6 months). During each study visit, subjects underwent anthropometric measurements and blood testing for biochemical analysis, immune function assay, inflammatory cytokines assay, and FibroMax test.
Results
The ACM supplemented group had a significant improvement in steatosis and decreased in the inflammatory marker of TNF-α after three and six months. NASH patients who received ACM showed a significant decrease in the SteatoTest mean value from 0.66 at baseline to 0.49 at 6 months (p < 0.029) and the ActiTest mean value decreased from 0.46 at baseline to 0.30 at 6 months (p < 0.029).
Conclusion
This is the first clinical investigation that explores the hepatoprotective effect of A. cinnamomea mycelium in patients with NASH. No participants experienced any adverse events during the study, which suggested that ACM is a safe alternative treatment for NASH.
論文出處：Front Immunol. 2021 May 14;12:664425. doi: 10.3389/fimmu.2021.664425.
論文名稱：2,4-Dimethoxy-6-Methylbenzene-1,3-diol, a Benzenoid From Antrodia cinnamomea, Mitigates Psoriasiform Inflammation by Suppressing MAPK/NF-kappaB Phosphorylation and GDAP1L1/Drp1 Translocation.
作 者：Chuang SY, Chen CY, Yang SC, Alalaiwe A, Lin CH, Fang JY.
出 版 年：2021
分 類：抗發炎
論文結論：Antrodia cinnamomea exhibits anti-inflammatory, antioxidant, and immunomodulatory activities. We aimed to explore the antipsoriatic potential of 2,4-dimethoxy-6-methylbenzene-1,3-diol (DMD) derived from A. cinnamomea. The macrophages activated by imiquimod (IMQ) were used as the cell model for examining the anti-inflammatory effect of DMD in vitro. A significantly high inhibition of IL-23 and IL-6 by DMD was observed in THP-1 macrophages and bone marrow-derived mouse macrophages. The conditioned medium of DMD-treated macrophages could reduce neutrophil migration and keratinocyte overproliferation. DMD could downregulate cytokine/chemokine by suppressing the phosphorylation of mitogen-activated protein kinases (MAPKs) and NF-κB. We also observed inhibition of GDAP1L1/Drp1 translocation from the cytoplasm to mitochondria by DMD intervention. Thus, mitochondrial fission could be a novel target for treating psoriatic inflammation. A psoriasiform mouse model treated by IMQ showed reduced scaling, erythema, and skin thickening after topical application of DMD. Compared to the IMQ stimulation only, the active compound decreased epidermal thickness by about 2-fold. DMD diminished the number of infiltrating macrophages and neutrophils and their related cytokine/chemokine production in the lesional skin. Immunostaining of the IMQ-treated skin demonstrated the inhibition of GDAP1LI and phosphorylated Drp1 by DMD. The present study provides insight regarding the potential use of DMD as an effective treatment modality for psoriatic inflammation.
論文出處：Phytother Res. 2021 Mar;35(3):1609-1620. doi: 10.1002/ptr.6928.
論文名稱：Protective effects of Antrodia camphorata extract against hypoxic cell injury and ischemic stroke brain damage.
作 者：Kong ZL, Hsu YT, Johnson A, Tsai TH, Miao S, He JL, Tsou D.
出 版 年：2021
分 類：抗發炎
論文結論：Ischemic stroke is the most prevalent stroke condition in the world resulted in either a transient ischemic attack or long-lasting neurological problems due to the interrupted or reduced blood flow to the brain. Antrodia camphorata is a well-known medicinal mushroom native to Taiwan and is familiar due to its medicinal effects. The current study investigated the protective effect of A. camphorata-alcohol extracts (AC-AE) against cobalt (II) chloride (CoCl2)-induced oxidative stress in vitro and ischemia/reperfusion-induced brain injury in vivo. The rats were pre-treated with AC-AE for 4 weeks. Our results showed that AC-AE reduced cell damage and decreased reactive oxygen species (ROS) production in C6 and PC12 cells under CoCl2-induced hypoxic condition. AC-AE doses (385, 770, 1,540 mg/kg/day, 4 weeks) increased nuclear factor erythroid 2–related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) mRNA expressions and decreased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expressions in Sprague Dawley rat. Besides, it decreased stroke infarct size and increased the level of antioxidants in both brain and serum. Furthermore, it reduced the formation of malondialdehyde (MDA) after ischemia/reperfusion (I/R). Our results suggested that AC-AE exerted an effective reduction of ischemia stroke by regulating ROS production.dysfunction.
論文出處：Phytochemistry. 2021 Apr;184:112677. doi: 10.1016/j.phytochem.2021.112677.
論文名稱：Enhancement of antroquinonol production via the overexpression of 4-hydroxybenzoate polyprenyltransferase biosynthesis-related genes in Antrodia cinnamomea.
作 者：Liu X, Xia Y, Zhang Y, Liang L, Xiong Z, Wang G, Song X, Ai L.
出 版 年：2021
分 類：抗發炎
論文結論：Antroquinonol (AQ) as one of the most potent bioactive components in Antrodia cinnamomea (Fomitopsidaceae) shows a broad spectrum of anticancer effects. The lower yield of AQ has hampered its possible clinical application. AQ production may potentially be improved by genetic engineering. In this study, the protoplast-polyethylene glycol method combined with hygromycin as a selection marker was used in the genetic engineering of A. cinnamomea S-29. The optimization of several crucial parameters revealed that the optimal condition for generating maximal viable protoplasts was digestion of 4-day-old germlings with a mixture of enzymes (lysing enzyme, snailase, and cellulase) and 1.0 M MgSO4 for 4 h. The ubiA and CoQ2 genes, which are involved in the synthesis of 4-hydroxybenzoate polyprenyltransferase, were cloned and overexpressed in A. cinnamomea. The results showed that ubiA and CoQ2 overexpression significantly increased AQ production in submerged fermentation. The overexpressing strain produced maximum AQ concentrations of 14.75 ± 0.41 mg/L and 19.25 ± 0.29 mg/L in pCT74-gpd-ubiA and pCT74-gpd-CoQ2 transformants, respectively. These concentrations were 2.00 and 2.61 times greater than those produced by the control, respectively. This research exemplifies how the production of metabolites may be increased by genetic manipulation, and will be invaluable to guide the genetic engineering of other mushrooms that produce medically useful compounds.
論文出處：Curr Mol Pharmacol. 2021 Jan 20. doi: 10.2174/1874467214666210120152140.
論文名稱：Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 against Alcoholic Fatty Liver Disease.
作 者：Xu L, Peng AK, Cao YN, Qiao X, Yue SS, Ye M, Qi R.
出 版 年：2021
分 類：抗發炎
論文結論：Background: Alcoholic fatty liver disease (AFLD), a leading chronic hepatic disease, affects an increasing number of people, and no effective drugs for the treatment of AFLD are available. Antrodia cinnamomea (AC) can inhibit AFLD, but its mechanisms and the effective compound in AC are unknown.
Objective: We aimed to explore the anti-AFLD mechanism of AC and the active compound within AC.
Methods: Wild-type (WT) C57BL/6J mice underwent 4 weeks of daily ethanol (EtOH) feeding to induce AFLD. AC or dehydroeburicoic acid 32 (DEA32), a compound in AC, was given to the mice. Parallel experiments to assess the effect of AC were conducted in aldehyde dehydrogenase 2 (ALDH2)-knockout (KO) mice. Primary mouse hepatocytes were incubated with ethanol and Alda-1 (an ALDH2 agonist), AC or DEA32.
Results: In WT mice with AFLD, AC reduced lipid deposition, increased the expression and activity of ALDH2, reduced the acetaldehyde content, and downregulated the expression of lipogenic and inflammatory genes in the liver. These effects of AC disappeared in ALDH2 KO mice. DEA32 was identified as an active compound in AC, as its effects on EtOH-treated WT hepatocytes were similar to those of AC, which were comparable to the effects of Alda-1. These effects of DEA32 disappeared in EtOH-treated ALDH2 KO hepatocytes. Furthermore, in WT mice with AFLD, DEA32 reduced lipid deposition, increased the activity of ALDH2 and reduced the accumulation of acetaldehyde in the liver. DEA32 also downregulated the mRNA expression of genes related to lipogenesis and inflammation.
Conclusion: AC and its constituent compound DEA32 inhibit AFLD by upregulating ALDH2 activity, accelerating acetaldehyde metabolism and suppressing lipogenesis and inflammation in the liver.
論文出處：Int J Mol Sci. 2020 Sep 22;21(18):6971. doi: 10.3390/ijms21186971.
論文名稱：4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model.
作 者：Wu CH, Ou CH, Yen IC, Lee SY.
出 版 年：2020
分 類：抗發炎
論文結論：Astronauts suffer from 1–2% bone loss per month during space missions. Targeting osteoclast differentiation has been regarded as a promising strategy to prevent osteoporosis in microgravity (μXg). 4-acetylantroquinonol B (4-AAQB), a ubiquinone from Antrodia cinnamomea, has shown anti-inflammatory and anti-hepatoma activities. However, the effect of 4-AAQB on μXg-induced osteoclastogenesis remains unclear. In this study, we aimed to explore the mechanistic impact of 4-AAQB on osteoclast formation under μXg conditions. The monocyte/macrophage-like cell line RAW264.7 was exposed to simulated μXg (Rotary Cell Culture System; Synthecon, Houston, TX, USA) for 24 h and then treated with 4-AAQB or alendronate (ALN) and osteoclast differentiation factor receptor activator of nuclear factor kappa-B ligand (RANKL). Osteoclastogenesis, bone resorption activity, and osteoclast differentiation-related signaling pathways were analyzed using tartrate-resistant acid phosphatase (TRAP) staining, actin ring fluorescent staining, bone resorption, and western blotting assays. Based on the results of TRAP staining, actin ring staining, and bone resorption assays, we found that 4-AAQB significantly inhibited μXg-induced osteoclast differentiation. The critical regulators of osteoclast differentiation, including nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), c-Fos, and dendritic cell-specific transmembrane protein (DC-STAMP), were consistently decreased. Meanwhile, osteoclast apoptosis and cell cycle arrest were also observed along with autophagy suppression. Interestingly, the autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ) showed similar effects to 4-AAQB. In conclusion, we suggest that 4-AAQB may serve as a potential agent against μXg-induced osteoclast formation.
論文出處：Molecules. 2020 Sep 14;25(18):4213. doi: 10.3390/molecules25184213.
論文名稱：Antrodia cinnamomea Extraction Waste Supplementation Promotes Thermal Stress Tolerance and Tissue Regeneration Ability of Zebrafish.
作 者：Chang CC, Lu YC, Wang CC, Ko TL, Chen JR, Wang W, Chen YL, Wang YW, Chang TH, Hsu HF, Houng JY.
出 版 年：2020
分 類：抗發炎
論文結論：Antrodia cinnamomea (AC) has been shown to have anti-inflammatory, anti-tumor, and immunomodulation activities. It is estimated that hundreds of metric tons of AC extraction waste (ACEW) are produced per year in Taiwan. This study aims to assess the feasibility of applying ACEW as feed supplement in the aquaculture industry. ACEW significantly inhibited the growth of microorganisms in the water tank, by around 39.4% reduction on the fifth day with feed supplemented of 10% ACEW. The feed conversion efficiency of zebrafish with 10% ACEW supplementation for 30 days was 1.22-fold compared to that of the control. ACEW dramatically improved the tolerances of zebrafish under the heat and cold stresses. When at water temperature extremes of 38 °C or 11 °C, compared to the 100% mortality rate in the control group, the 10% ACEW diet group still had 91.7% and 83.3% survival rates, respectively. In a caudal fin amputation test, the fin recovery of zebrafish was increased from 68.4% to 93% with 10% ACEW diet after 3-week regeneration. ACEW effectively down-regulated the gene expression of TNF-α, IL-1β, IL-6, and IL-10, and up-regulated the gene expression of IL-4/13A. Additionally, the supplement of ACEW in the feed can maintain and prevent the fish’s body weight from dropping too much under enteritis. Taken together, ACEW has beneficial potential in aquaculture.
論文出處：Nutrients. 2020 Sep 11;12(9):2778. doi: 10.3390/nu12092778.
論文名稱：Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl(4)-Induced Liver Fibrosis in Mice.
作 者：Ren Y, Li HX, Zhou L, Lu ZM, Shi J, Geng Y, Xu ZH.
出 版 年：2020
分 類：抗發炎
論文結論：Liver fibrosis is a pathological process with intrahepatic diffused deposition of the excess extracellular matrix, which leads to various chronic liver diseases. Drugs with high efficacy and low toxicity for liver fibrosis are still unavailable. Antrodia camphorata has antioxidant, antivirus, antitumor and anti-inflammation roles, and has been used to treat liver diseases in the population. However, the hepatoprotective effects of A. camphorata spores and the mechanisms behind it have not been investigated. In this study, we evaluate the hepatoprotective effect of spore powder of A. camphorata (SP, 100 mg/kg/day or 200 mg/kg/day) on carbon tetrachloride (CCl4)-induced liver fibrosis in mice. SP groups reduced serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities compared with the CCl4 group. SP also showed a decrease in hydroxyproline (Hyp) content in liver tissues. SP improved cell damage and reduced collagen deposition by H&E, Sirius red and Masson staining. Furthermore, SP down-regulated the mRNA levels of α-SMA and Col 1, and the protein expression of α-smooth muscle actin (α-SMA), collagen I (Col 1), tumor necrosis factor alpha (TNF-α), toll like receptor 4 (TLR4) and nuclear factor-Κb (NF-κB) p65. In summary, SP has an ameliorative effect on hepatic fibrosis, probably by inhibiting the activation of hepatic stellate cells, reducing the synthesis of extracellular matrix.
論文出處：Asian-Australas J Anim Sci. 2020 Jul;33(7):1167-1179. doi: 10.5713/ajas.19.0393.
論文名稱：Effects of dietary Antrodia cinnamomea fermented product supplementation on metabolism pathways of antioxidant, inflammatory, and lipid metabolism pathways-a potential crosstalk.
作 者：Lee MT, Lin WC, Lin LJ, Wang SY, Chang SC, Lee TT.
出 版 年：2020
分 類：抗發炎
論文結論：Objective
This study was conducted to fathom the underlying mechanisms of nutrition intervention and redox sensitive transcription factors regulated by Antrodia cinnamomea fermented product (FAC) dietary supplementation in broiler chickens.
Methods
Four hundreds d-old broilers (41±0.5 g/bird) assigned to 5 groups were examined after consuming control diet, or control diet replaced with 5% wheat bran (WB), 10% WB, 5% FAC, and 10% FAC. Liver mRNA expression of antioxidant, inflammatory and lipid metabolism pathways were analyzed. Prostaglandin E2 (PGE2) concentration in each group were tested in the chicken peripheral blood mononuclear cells (cPBMCs) of 35-d old broilers to represent the stress level of the chickens. Furthermore, these cells were stimulated with 2,2′-Azobis(2-amidinopropane) dihydrochloride (AAPH) and lipopolysaccharide (LPS) to evaluate the cell stress tolerance by measuring cell viability and oxidative species.
Results
Heme oxygenase-1, glutathione S-transferase, glutamate-cysteine ligase, catalytic subunit, and superoxide dismutase, and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) that regulates the above antioxidant genes were all up-regulated significantly in FAC groups. Reactive oxygen species modulator protein 1 and NADPH oxygenase 1 were both rather down-regulated in 10% FAC group as comparison with two WB groups. Despite expressing higher level than control group, birds receiving diet containing FAC had significantly lower expression level in nuclear factor-kappa B (NF-κB) and other genes (inducible nitric oxide synthase, tumor necrosis factor-α, interleukin-1β, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3, and cyclooxygenase 2) involving in inflammatory pathways. Additionally, except for 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase that showed relatively higher in both groups, the WB, lipoprotein lipase, Acetyl-CoA carboxylase, fatty acid synthase, fatty acid binding protein, fatty acid desaturase 2 and peroxisome proliferator-activated receptor alpha genes were expressed at higher levels in 10% FAC group. In support of above results, promoted Nrf2 and inhibited NF-κB nuclear translocation in chicken liver were found in FAC containing groups. H2O2 and NO levels induced by LPS and AAPH in cPBMCs were compromised in FAC containing diet. In 35-d-old birds, PGE2 production in cPBMCs was also suppressed by the FAC diet.
Conclusion
FAC may promote Nrf2 antioxidant pathway and positively regulate lipid metabolism, both are potential inhibitor of NF-κB inflammatory pathway.
論文出處：Asian-Australas J Anim Sci. 2020 Jul;33(7):1113-1125. doi: 10.5713/ajas.19.0392.
論文名稱：1. Effects of dietary Antrodia cinnamomea fermented product supplementation on antioxidation, anti-inflammation, and lipid metabolism in broiler chickens.
作 者：Lee MT, Lin WC, Lin LJ, Wang SY, Chang SC, Lee TT.
出 版 年：2020
分 類：抗發炎
論文結論：Objective
This study was investigated the effects of dietary supplementation of Antrodia cinnamomea fermented product on modulation of antioxidation, anti-inflammation, and lipid metabolism in broilers.
Methods
Functional compounds and in vitro antioxidant capacity were detected in wheat bran (WB) solid-state fermented by Antrodia cinnamomea for 16 days (FAC). In animal experiment, 400 d-old broiler chickens were allotted into 5 groups fed control diet, and control diet replaced with 5% WB, 10% WB, 5% FAC, and 10% FAC respectively. Growth performance, intestinal microflora, serum antioxidant enzymes and fatty acid profiles in pectoral superficial muscle were measured.
Results
Pretreatment with hot water extracted fermented product significantly reduced chicken peripheral blood mononuclear cells death induced by lipopolysaccharide and 2,2′-Azobis(2-amidinopropane) dihydrochloride. Birds received 5% and 10% FAC had higher weight gain than WB groups. Cecal coliform and lactic acid bacteria were diminished and increased respectively while diet replaced with FAC. For FAC supplemented groups, superoxide dismutase (SOD) activity increased at 35 days only, with catalase elevated at 21 and 35 day. Regarding serum lipid parameters, 10% FAC replacement significantly reduced triglyceride and low-density lipoprotein level in chickens. For fatty acid composition in pectoral superficial muscle of 35-d-old chickens, 5% and 10% FAC inclusion had birds with significantly lower saturated fatty acids as compared with 10% WB group. Birds on the 5% FAC diet had a higher degree of unsaturation, followed by 10% FAC, control, 5% WB, and 10% WB.
Conclusion
In conclusion, desirable intestinal microflora in chickens obtaining FAC may be attributed to the functional metabolites detected in final fermented product. Moreover, antioxidant effects observed in FAC were plausibly exerted in terms of improved antioxidant enzymes activities, increased unsaturated degree of fatty acids in chicken muscle and better weight gain in FAC inclusion groups, indicating that FAC possesses promising favorable mechanisms worthy to be developed.
論文出處：Front Microbiol. 2020 Jul 3;11:1113. doi: 10.3389/fmicb.2020.01113.
論文名稱：Triterpenoids Extracted From Antrodia cinnamomea Mycelia Attenuate Acute Alcohol-Induced Liver Injury in C57BL/6 Mice via Suppression Inflammatory Response.
作 者：Liu Y, Wang Z, Kong F, Teng L, Zheng X, Liu X, Wang D.
出 版 年：2020
分 類：抗發炎
論文結論：Excessive alcohol consumption causes liver injury–induced mortality. Here we systematically analyzed the structure of triterpenoids extracted from Antrodia cinnamomea mycelia (ACT) and investigated their protective effects against acute alcohol-induced liver injury in mice. Liquid chromatography–mass spectrometry and liquid chromatography with tandem mass spectrometry were performed to determine the structures of ACT constituents. Alcohol-induced liver injury was generated in C57BL/6 mice by oral gavage of 13 g/kg white spirit (a wine at 56% ABV). Mice were treated with either silibinin or ACT for 2 weeks. Liver injury markers and pathological signaling were then quantified with enzyme-linked immunosorbent assays, antibody array assays, and Western blots, and pathological examinations were performed using hematoxylin-eosin staining and periodic acid–Schiff staining. Triterpenoids extracted from A. cinnamomea mycelia contain 25 types of triterpenoid compounds. A 2-weeks alcohol consumption treatment caused significant weight loss, liver dyslipidemia, and elevation of alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, and alkaline phosphatase activities in the serum and/or liver. These effects were markedly reversed after 2-weeks ACT administration. Triterpenoids extracted from A. cinnamomea mycelia alleviated the organ structural changes and inflammatory infiltration of alcohol-damaged tissues. Triterpenoids extracted from A. cinnamomea mycelia inhibited proinflammatory cytokine levels and enhanced anti-inflammatory cytokine levels. Acute alcohol treatment promoted inflammation with significant correlations to hypoxia-inducible factor 1α (HIF-1α), which was reduced by ACT and was partially related to modulation of the protein kinase B (Akt)/70-kDa ribosomal protein S6 kinase phosphorylation (p70S6K) and Wnt/β-catenin signaling pathways. In conclusion, ACT protected against acute alcohol-induced liver damage in mice mainly through its suppression of the inflammatory response, which may be related to HIF-1α signaling.
論文出處：Int J Nanomedicine. 2020 Jun 15;15:4191-4203. doi: 10.2147/IJN.S252885.
論文名稱：Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats.
作 者：Kong ZL, He JL, Sudirman S, Kuo MT, Miao S, Chang KB, Tsou D.
出 版 年：2020
分 類：抗發炎
論文結論：Purpose: To characterize the nanoparticle of antroquinonol from A. cinnamomea and its ameliorative effects on the reproductive dysfunction in the diabetic male rat.
Material and Methods: The chitosan-silicate nanoparticle was used as the carrier for the delivery of antroquinonol from solid-state-cultured A. cinnamomea extract (AC). The rats were fed with a high-fat diet and intraperitoneally injected with streptozotocin to induce diabetes. The rats were daily oral gavage by water [Diabetes (DM) and Control groups], three different doses of chitosan-silicate nanoparticle of antroquinonol from solid-state-cultured A. cinnamomea (nano-SAC, NAC): (DM+NAC1x, 4 mg/kg of body weight; DM+NAC2x, 8 mg/kg; and DM+NAC5x, 20 mg/kg), solid-state-cultured AC (DM+AC5x, 20 mg/kg), or metformin (DM+Met, 200 mg/kg) for 7 weeks.
Results: The nano-SAC size was 37.68± 5.91 nm, the zeta potential was 4.13± 0.49 mV, encapsulation efficiency was 79.29± 0.77%, and loading capacity was 32.45± 0.02%. The nano-SAC can improve diabetes-induced reproductive dysfunction by regulating glucose, insulin, and oxidative enzyme and by increasing the level of testosterone, follicle-stimulating hormone, luteinizing hormone, and sperm count as well as sperm mobility. In testicular histopathology, the seminiferous tubules of A. cinnamomea-supplemented diabetic rats showed similar morphology with the control group.
Conclusion: The nanoparticle of antroquinonol from Antrodia cinnamomea can be used as an effective strategy to improve diabetes-induced testicular dysfunction.
論文出處：Biomed Pharmacother. 2019 Apr;112:108684. doi: 10.1016/j.biopha.2019.108684. Epub 2019 Feb 21.
論文名稱：Attenuation of reproductive dysfunction in diabetic male rats with timber cultured Antrodia cinnamomea ethanol extract.
作 者：Johnson A, Cheng SC, Tsou D, Kong ZL.
出 版 年：2019
分 類：抗發炎
論文結論：Diabetes mellitus together with the oxidative stress affects the process of spermatogenesis and leads to male infertility. Antrodia cinnamomea ethanol extract (ACEE) has anti-inflammatory and ameliorative effects to prevent diabetes-induced male reproductive dysfunction. ACEE improved STZ-NA (streptozotocin (STZ) (65 mg/kg) and nicotinamide (NA) (230 mg/kg)) induced hyperglycemia, oxidative stress, and insulin resistance. ACEE reduced the degree of lipid peroxidation, recovered the abnormal structure of the seminiferous tubules, and improved sperm parameters.
論文出處：Int J Mol Sci. 2019 Feb 15;20(4). pii: E846. doi: 10.3390/ijms20040846.
論文名稱：Protective Effect of Antrodia cinnamomea Extract against Irradiation-Induced Acute Hepatitis.
作 者：Kuo TH, Kuo YH, Cho CY, Yao CJ, Lai GM, Chuang SE.
出 版 年：2019
分 類：抗發炎
論文結論：Radiotherapy for treatment of hepatocellular carcinoma causes severe side effects, including acute hepatitis and chronic fibrosis. In normal liver cell line CL48, ethanol extract of Antrodia cinnamomea (ACE) protects cells by eliminating irradiation-induced reactive oxygen species (ROS) through the induction of Nrf2 and the downstream redox system enzymes. The protective effect of ACE was also demonstrated in tumor-bearing mice by alleviating irradiation-induced acute hepatitis. ACE could also protect mice from CCl₄-induced hepatitis. ACE likely contains active components that protect normal liver cells from free radical attack and can potentially benefit hepatocellular carcinoma (HCC) patients during radiotherapy.
論文出處：J Food Drug Anal. 2019 Jan;27(1):295-304. doi: 10.1016/j.jfda.2018.11.004. Epub 2018 Dec 4.
論文名稱：Antcins, triterpenoids from Antrodia cinnamomea, as new agonists for peroxisome proliferator-activated receptor α.
作 者：Wang YJ, Lee SC, Hsu CH, Kuo YH, Yang CC, Lin FJ.
出 版 年：2019
分 類：抗發炎
論文結論：Peroxisome proliferator-activated receptor α (PPARα) is a nuclear hormone receptor that transcriptionally regulates lipid metabolism and inflammation. Antcin B, H and K (antcins) and ergostatrien-3β-ol (EK100) are bioactive compounds isolated from Antrodia cinnamomea with anti-inflammatory actions. These sterol-based compounds, antcins, but not EK100, activate PPARα in a cell-based transactivation.
論文出處：J Food Drug Anal. 2019 Jan;27(1):184-194. doi: 10.1016/j.jfda.2018.09.008. Epub 2018 Oct 25.
論文名稱：CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways.
作 者：Lin IY, Chiou YS, Wu LC, Tsai CY, Chen CT, Chuang WC, Lee MC, Lin CC, Lin TT, Chen SC, Pan MH, Ma N.
出 版 年：2019
分 類：抗發炎
論文結論：CCM111, an aqueous extract of Antrodia cinnamomea (AC), can protect against CCl4-induced liver fibrosis by the cooperative inhibition of TGF-β-, Wnt- and STAT3-dependent proinflammatory and profibrotic mediators.
論文出處：Int J Med Mushrooms. 2018;20(9):849-858. doi: 10.1615/IntJMedMushrooms.2018027389.
論文名稱：Immunomodulatory Effects of the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes)-Based Health Food Product in Mice.
作 者：Lin YH, Kuo JT, Chen YY, Kumar KJS, Lo CP, Lin CC, Wang SY.
出 版 年：2018
分 類：抗發炎
論文結論：A health food product “leader Antrodia cinnamomea capsule” (LAC), containing solid-state cultivated mycelial powder, can modulate immune function. LAC significantly increased splenic lymphocyte proliferation, increased the half value of serum hemolysin (HC50) in mice and increased the phagocytic index as measured by carbon clearance and natural killer cell activity.
論文出處：Am J Chin Med. 2018 Aug 27:1-17. doi: 10.1142/S0192415X18500684. [Epub ahead of print]
論文名稱：Antrolone, a Novel Benzoid Derived from Antrodia cinnamomea, Inhibits the LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells by Balancing the NF-[Formula: see text]B and Nrf2 Pathways.
作 者：Yen IC, Shi LS, Chung MC, Ahmetaj-Shala B, Chang TC, Lee SY
出 版 年：2018
分 類：抗發炎
論文結論：Antrolone, a novel benzoid derived from Antrodia cinnamomea mycelium, exhibits potent anti-inflammatory activity. It significantly decreased LPS-induced NO, PGE2, pro-inflammatory cytokine, and keratinocyte chemoattractant CXCL1 (KC) production and reduced levels of the proteins inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2).
論文出處：Mycology. 2018 Feb 21;9(2):129-135. doi: 10.1080/21501203.2018.1437837. eCollection 2018.
論文名稱：Effects of Taiwanofungus camphoratus on non-specific and specific immune activities in mice.
作 者：Chen YY, Lo CP, Lin CC, Hsieh YH
出 版 年：2018
分 類：抗發炎
論文結論：
The proliferation of splenic immune cells, phagocytic activity of macrophages and cytolytic activity of natural killer cells were enhanced by Leader Antrodia cinnamomea (LAC). LAC increased the levels of IL-2, TNF-α, INF-γ, GM-CSF and serum OVA-IgG and OVA-IgM.
論文出處：Int J Biol Sci. 2018 Jul 27;14(10):1378-1388. doi: 10.7150/ijbs.24564. eCollection 2018.
論文名稱：Antrodia cinnamomea Galactomannan Elicits Immuno-stimulatory Activity Through Toll-like Receptor 4.
作 者：Perera N, Yang FL, Lu YT, Li LH, Hua KF, Wu SH
出 版 年：2018
分 類：抗發炎
論文結論：
The cold water-soluble polysaccharide was isolated from Antrodia cinnamomea (galactomannan-repeated; MW>70 kDa; named ACP) , as an immunostimulator or an adjuvant in immunotherapy and vaccination.
論文出處：Oncotarget. 2018 Apr 13;9(28):19584-19596. doi: 10.18632/oncotarget.24680. eCollection 2018 Apr 13.
論文名稱：Anti-cachectic effect of Antrodia cinnamomea extract in lung tumor-bearing mice under chemotherapy.
作 者：Chen MC, Hsu WL, Chou TC
出 版 年：2018
分 類：抗發炎
論文結論：Antrodia cinnamomea (AC) extract has a protective effect against chemotherapy-induced muscle atrophy mainly by attenuating muscle proteolysis, pro-inflammatory cytokine production, and anorexia, and activating IGF-1-dependent protein synthesis.
論文出處：Int J Biol Macromol. 2018 May 4;116:8-15. doi: 10.1016/j.ijbiomac.2018.04.178. [Epub ahead of print]
論文名稱：Ameliorative effects of Antrodia cinnamomea polysaccharides against cyclophosphamide-induced immunosuppression related to Nrf2/HO-1 signaling in BALB/c mice.
作 者：Liu Y, Yang A, Qu Y, Wang Z, Zhang Y, Liu Y, Wang N, Teng L, Wang D
出 版 年：2018
分 類：抗發炎
論文結論：Antrodia cinnamomea polysaccharide (ACPS) has potential for development as an effective anti-immunosuppressive agent in BALB/c mice.
論文出處：Poult Sci. 2018 Apr 17. doi: 10.3382/ps/pey076. [Epub ahead of print]
論文名稱：Evaluation of potential antioxidant and anti-inflammatory effects of Antrodia cinnamomea powder and the underlying molecular mechanisms via Nrf2- and NF-κB-dominated pathways in broiler chickens.
作 者：Lee MT, Lin WC, Wang SY, Lin LJ, Yu B, Lee TT
出 版 年：2018
分 類：抗發炎
論文結論：Antrodia cinnamomea powder (ACP) could induce the Nrf2-dependent pathway and decrease the NF-κB-dominated inflammatory signaling pathway.
論文出處：BMC Complement Altern Med. 2018 Mar 23;18(1):108. doi: 10.1186/s12906-018-2172-2.
論文名稱：4-Acetylantroquinonol B inhibits lipopolysaccharide-induced cytokine release and alleviates sepsis through of MAPK and NFκB suppression.
作 者：Chang CH, Hsu CC, Lee AS, Wang SW, Lin KT, Chang WL, Peng HC, Huang WC, Chung CH
出 版 年：2018
分 類：抗發炎
論文結論：4-acetylantroquinonol B (4AAQB) is isolated from the mycelium of Antrodia cinnamomea. 4AAQB exhibits anti-inflammatory effects inhibit tumor necrosis factor-α (TNF-α)/interleukin-6 (IL-6) releasing and LPS-stimulated phagocytes migration without affect cell growth. The MAPK kinase molecules phosphorylation in LPS-stimulated RAW264.7 macrophage including ERK, JNK and p38 was inhibited by 4AAQB. The phosphorylation of NFκB subunit p65 and IkBα were also decreased after 4AAQB treatment.
論文出處：Int J Biol Macromol. 2018 Mar 14. pii: S0141-8130(17)34670-6. doi: 10.1016/j.ijbiomac.2018.03.056. [Epub ahead of print]
論文名稱：Large-scale preparation of sulfated polysaccharides with anti-angionenic and anti-inflammatory properties from Antrodia cinnamomia.
作 者：Cheng JJ, Chao CH, Lu MK
出 版 年：2018
分 類：抗發炎
論文結論：The first report to large-scale produce Sulfated polysaccharides (SPSs) that isolated from Antrodia cinnamomea. And demonstrates sulfated galactoglucan with strong anti-inflammatory activity. It showed maximal inhibition of the tumor necrosis factor (TNF-α), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) on bacterial LPS-induced inflammation in RAW264.7 macrophage.
論文出處：Iran J Basic Med Sci. 2018 Mar;21(3):230-235. doi: 10.22038/ijbms.2018.21545.5554.
論文名稱：Amelioration of carbon tetrachloride-induced hepatic injury by emulsified Antrodia extract.
作 者：Chang WC, Hung CT, Chen YS, Hsueh CC, Hou CW, Lay HL
出 版 年：2018
分 類：抗發炎
論文結論：The hepatoprotection of emulsified Antrodia cinnamomea extract (EAE) could be attributed to the antioxidant and anti-inflammatory effects of Antrodia.
論文出處：Cytokine. 2018 Mar 29;108:136-144. doi: 10.1016/j.cyto.2018.03.035. [Epub ahead of print]
論文名稱：Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages.
作 者：Kao ST, Kuo YH, Wang SD, Hong HJ, Lin LJ
出 版 年：2018
分 類：抗發炎
論文結論：The pharmacologically active compounds in a crude solid-state-cultured mycelium of Antrodia camphorata (SCMAC) extract exert synergistic effects on multiple targets to relieve asthma symptoms.
論文出處：J Dermatol Sci. 2018 Nov;92(2):188-196. doi: 10.1016/j.jdermsci.2018.09.002. Epub 2018 Sep 7.
論文名稱：The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata.
作 者：Yang SC, Huang TH, Chiu CH, Chou WL, Alalaiwe A, Yeh YC, Su KW, Fang JY.
出 版 年：2018
分 類：抗發炎
論文結論：
2,4-Dimethoxy-6-methylbenzene-1,3-diol (DMD), is a benzenoid isolated from Antrodia camphorata, exhibited a comparative minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against methicillin-resistant S. aureus (MRSA) with nalidixic acid, a conventional antibiotic. Demonstrated an advanced concept of Atopic dermatitis (AD, an inflammatory skin disease) treatment by combined barrier repair and bacterial eradication with a sole agent for ameliorating the overall complications.
論文出處：Polymers (Basel). 2017 Jun 16;9(6). pii: E228. doi: 10.3390/polym9060228.
論文名稱：A Novel Heterogalactan from Antrodia camphorata and Anti-Angiogenic Activity of Its Sulfated Derivative.
作 者：Liu Y, Ding Y, Ye M, Zhu T, Tian D, Ding K.
出 版 年：2017
分 類：抗發炎
論文結論：
A heterogalactan, named ACW0, was extracted from Antrodia camphorata and purified by anion exchange and gel permeation chromatography. A sulfated polysaccharide, ACW0-Sul was achieved by the chlorosulfonic acid-pyridine method. ACW0-Sul could be a potent candidate for anti-angiogenic agent development. human microvascular endothelial cells (HMEC-1) “1. ACW0-Sul could disrupt tube formation and migration as well as cell growth of human microvascular endothelial cells (HMEC-1) dose-dependently.
2. Phosphorylation of Extracellular Regulated Protein Kinases (Erk) and Focal Adhesion Kinase (FAK) were significantly inhibited by ACW0-Sul.
論文出處：Molecules. 2017 Dec 26;23(1). pii: E51. doi: 10.3390/molecules23010051.
論文名稱：Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation.
作 者：Zheng J, Jiao S, Li Q, Jia P, Yin H, Zhao X, Du Y, Liu H
出 版 年：2017
分 類：抗發炎
論文結論：Two oligosaccharide products were prepared from Antrodia cinnamomea (AC) polysaccharides at 90 °C (ACHO) or 25 °C (ACCO), which displayed inhibitory effects on LPS-induced mRNA expression of pro-inflammatory cytokines including IL-6, IL-8, IL-1β, TNF-α and MCP-1 in macrophage cells in mice. The potential anti-inflammatory molecular mechanism may be associated with the promotion of protein O-GlcNAcylation, which further skewed toward the marked suppression of p38 and Akt phosphorylation.
論文出處：Oncotarget. 2017 Aug 4;8(57):96568-96587. doi: 10.18632/oncotarget.19951. eCollection 2017 Nov 14.
論文名稱：Activation of Nrf2-mediated anti-oxidant genes by antrodin C prevents hyperglycemia-induced senescence and apoptosis in human endothelial cells
作 者：Senthil KKJ, Gokila VM, Wang SY
出 版 年：2017
分 類：抗發炎
論文結論：Antrodin C (ADC), a maleimide derivative isolated from mycelia of Antrodia cinnamomea, may represent a promising intervention in diabetic-associated cardiovascular diseases by activating the Nrf2-dependent cellular anti-oxidant defense system.
論文出處：J Immunol Res. 2017;2017:7807313. doi: 10.1155/2017/7807313. Epub 2017 Aug 13.
論文名稱：Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation.
作 者：Lai CY, Su YW, Lin KI, Hsu LC, Chuang TH
出 版 年：2017
分 類：抗發炎
論文結論：Natural compounds derived from plants, fungi, and bacteria, including mustard seed, Antrodia cinnamomea extract, curcumin, resveratrol, thiostrepton, azithromycin, and andrographolide, inhibited psoriasis-like inflammation induced by the TLR7 agonist imiquimod in animal models. These natural modulators employ different mechanisms to inhibit endosomal TLR activation and are administered via different routes.
論文出處：In Vivo. 2017 Sep-Oct;31(5):877-884.
論文名稱：Antrodia Cinnamomea Reduces Carbon Tetrachloride-induced Hepatotoxicity In Male Wister Rats.
作 者：Shih YL, Wu MF, Lee CH, Yeh MY, Chou J, Liu JY, Lu HF, Huang YP, Liao NC, Chung JG
出 版 年：2017
分 類：抗發炎
論文結論：Antrodia cinnamomea can either enhance liver recovering from CCl4 damage or attenuate CCl4 toxicity in rats.
論文出處：Sci Rep. 2017 Jul 7;7(1):4862. doi: 10.1038/s41598-017-05072-y.
論文名稱：CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways.
作 者：Lin IY, Pan MH, Lai CS, Lin TT, Chen CT, Chung TS, Chen CL, Lin CH, Chuang WC, Lee MC, Lin CC, Ma N
出 版 年：2017
分 類：抗發炎
論文結論：CCM111, the water extract of Antrodia cinnamomea, significantly inhibited the IL-6-stimulated STAT3 pathway and the LPS-stimulated NF-κB pathway in macrophages. Also decreased the phosphorylation of STAT3, Tyk2 and the nuclear translocation of p65. Moreover, CCM111 and F4, a fraction of CCM111, down-regulated nitric oxide (NO) production, the protein levels of iNOS and COX-2, and inflammatory cytokines in macrophage cells.
論文出處：J Ethnopharmacol. 2017 Apr 18;202:200-207. doi: 10.1016/j.jep.2017.03.003. Epub 2017 Mar 6.
論文名稱：Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation in livers of chronic-alcohol fed mice.
作 者：Chang YY, Liu YC, Kuo YH, Lin YL, Wu YS, Chen JW, Chen YC
出 版 年：2017
分 類：抗發炎
論文結論：Hepatoprotection of antrosterol (a bioactive constitute of sterols from Antrodia camphorata) is mostly attributed to its regulations of lipid homeostasis, antioxidant capability, alcohol metabolism, and anti-inflammation.
論文出處：Environ Toxicol. 2017 Apr 3. doi: 10.1002/tox.22422. [Epub ahead of print]
論文名稱：Antrodia camphorata attenuates cigarette smoke-induced ROS production, DNA damage, apoptosis, and inflammation in vascular smooth muscle cells, and atherosclerosis in ApoE-deficient mice.
作 者：Yang HL, Korivi M, Chen CH, Peng WJ, Chen CS, Li ML, Hsu LS, Liao JW, Hseu YC
出 版 年：2017
分 類：抗發炎
論文結論：Fermented culture broth of Antrodia camphorata possesses effective antioxidant activity and decreased total cholesterol and triacylglycerol levels, against cigarette smoke extracts (CSE)-induced ROS production. In AC-treated A7r5 cells, improved CSE-induced morphological aberrations and cell death, upregulated SOD and catalase expressions. Suppressed ROS levels and inhibition of CSE-induced DNA damage and apoptosis.
論文出處：PLoS One. 2017 Apr 6;12(4):e0174008. doi: 10.1371/journal.pone.0174008. eCollection 2017.
論文名稱：Prevention of TGF-β-induced early liver fibrosis by a maleic acid derivative anti-oxidant through suppression of ROS, inflammation and hepatic stellate cells activation.
作 者：Yang KL, Chang WT, Hong MY, Hung KC, Chuang CC
出 版 年：2017
分 類：抗發炎
論文結論：A maleic acid derivative, isolated from Antrodia camphorata mycelium, prevents liver fibrosis at an early phase both in vitro and in vivo through the inhibition of ROS, inflammation and the activation of HSC. Decreases ROS production, promoter activity of Cox-2 and Col 1A2, intracellular calcium, expression of alpha-smooth muscle actin (α-SMA), Smad4-p-Smad2/3 co-localization in cell nucleus and the DNA binding activity of Sp1.
論文出處：J Ethnopharmacol. 2017 May 12. pii: S0378-8741(17)30084-3. doi: 10.1016/j.jep.2017.05.020. [Epub ahead of print]
論文名稱：Hepatoprotective activities of Antrodia camphorata and its triterpenoid compounds against CCl4-induced liver injury in mice.
作 者：Li ZW, Kuang Y, Tang SN, Li K, Huang Y, Qiao X, Yu SW, Tzeng YM, Lo JY, Ye M
出 版 年：2017
分 類：抗發炎
論文結論：Cultivation techniques remarkably affect the hepatoprotective activities of Antrodia camphorata. Antcin K and antcin B are the major hepatoprotective compounds of Antrodia camphorata, and the mechanism is related with anti-inflammation. Given its high natural abundance and good oral absorption, antcin K could be a promising drug candidate for liver injury.
論文出處：Int J Biol Macromol. 2017 Jun 19. pii: S0141-8130(17)30558-5. doi: 10.1016/j.ijbiomac.2017.05.191. [Epub ahead of print]
論文名稱：β-D-glucan from Antrodia Camphorata ameliorates LPS-induced inflammation and ROS production in human hepatocytes.
作 者：Chen Q, Tang H, Zha Z, Yin H, Wang Y, Wang Y, Li H, Yue L
出 版 年：2017
分 類：抗發炎
論文結論：A water soluble Antrodia Camphorata polysaccharide was composed of β-D-glucan, coded as ACP1. Which consisted of →1,3)-linked-β-D-Glcp-(6→, →3)-linked-β-D-Glcp-(1→, and →6)-linked-α-D-Galp-(1→, with terminal β-D-Glcp and β-D-Galp. And ACP1 was very likely to alleviate oxidation and inflammation.
論文出處：Antioxid Redox Signal. 2017 Feb 10;26(5):207-220. doi: 10.1089/ars.2016.6833. Epub 2016 Oct 11.
論文名稱：Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria.
作 者：Huo Y, Win S, Than TA, Yin S, Ye M, Hu H, Kaplowitz N
出 版 年：2017
分 類：抗發炎
論文結論：Antcin H (a triterpenoid isolated from Antrodia Camphorate) contributes to the hepatoprotective effect, and protects against liver injury through disruption of the binding of p-JNK to Sab, which interferes with the ROS-dependent self-sustaining activation of MAPK cascade.
論文出處：Am J Chin Med. 2017;45(1):173-198. doi: 10.1142/S0192415X17500124. Epub 2017 Jan 13.
論文名稱：Fruiting Bodies of Antrodia cinnamomea and Its Active Triterpenoid, Antcin K, Ameliorates N-Nitrosodiethylamine-Induced Hepatic Inflammation, Fibrosis and Carcinogenesis in Rats.
作 者：Tien AJ, Chien CY, Chen YH, Lin LC, Chien CT
出 版 年：2017
分 類：抗發炎
論文結論：Antrodia cinnamomea water extract (ACW) and its active component, Antcin K, counteract N-nitrosodiethylamine (DEN)-induced hepatic injury and inflammation by the protective and therapeutic mechanisms of a direct scavenging reactive oxygen species (ROS) activity and an upregulation of anti-oxidant defense mechanisms.
論文出處：Oxid Med Cell Longev. 2017;2017:7841823. doi: 10.1155/2017/7841823. Epub 2017 Feb 27.
論文名稱：Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol-Induced Acute Liver Injury.
作 者：Liu Y, Wang J, Li L, Hu W, Qu Y, Ding Y, Meng L, Teng L, Wang D
出 版 年：2017
分 類：抗發炎
論文結論：Antrodia cinnamomea (AC) reduced the incidence rate of necrosis, inflammatory infiltration, fatty droplets formation, and cell apoptosis. Reduced the expression of cleaved caspase-3, -8, and -9 and the levels of phosphor-protein kinase B (Akt) and phosphor-nuclear factor-κB (NF-κB) in liver of the mouse model.
論文出處：Biomed Res Int. 2017;2017:9374026. doi: 10.1155/2017/9374026. Epub 2017 Mar 23.
論文名稱：Antifatigue Effects of Antrodia cinnamomea Cultured Mycelium via Modulation of Oxidative Stress Signaling in a Mouse Model.
作 者：Liu Y, Li L, An S, Zhang Y, Feng S, Zhao L, Teng L, Wang D
出 版 年：2017
分 類：抗發炎
論文結論：The antifatigue properties of Antrodia cinnamomea may be one such modulation mechanism via oxidative stress-related signaling in mice.
論文出處：Org Lett. 2017 Jun 13. doi: 10.1021/acs.orglett.7b01468. [Epub ahead of print]
論文名稱：Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages.
作 者：Perera N, Yang FL, Chang CM, Lu YT, Zhan SH, Tsai YT, Hsieh JF, Li LH, Hua KF, Wu SH
出 版 年：2017
分 類：抗發炎
論文結論：Galactomannan with an octasaccharide-repeating unit (ACP) was isolated from Antrodia cinnamomea. ACP enhanced the phagocytosis and bactericidal activity of J774A.1 murine macrophages against Escherichia coli, with prospects for developing a new immunomodulatory compound or adjuvant in immunotherapy and vaccination.
論文出處：Hepatol Res. 2016 Mar;46(3):E15-25. doi: 10.1111/hepr.12516. Epub 2015 Apr 7.
論文名稱：Identification of antrodin B from Antrodia camphorata as a new anti-hepatofibrotic compound using a rapid cell screening method and biological evaluation.
作 者：Geng Y, Wang J, Sun Q, Xie M, Lu ZM, Xu HY, Shi JS, Xu ZH
出 版 年：2016
分 類：抗發炎
論文結論：
Developed a simple assay based on TGF-β1-induced total collagen accumulation in CFSC-8B cells and identified antrodin B which may serve as a potential candidate for treatment of liver fibrosis, that ameliorated cell proliferation, cell migration, suppressed HSC activation marker α-smooth muscle actin expression and ECM components Col1, Col3 and Fn expression, and blocked the phosphorylation of Smad2/3 induced by TGF-β1 in CFSC-8B cells.
論文出處：Int Immunopharmacol. 2016 Feb;31:186-94. doi: 10.1016/j.intimp.2015.12.030. Epub 2015 Dec 30.
論文名稱：4,7-Dimethoxy-5-methyl-1,3-benzodioxole from Antrodia camphorata inhibits LPS-induced inflammation via suppression of NF-κB and induction HO-1 in RAW264.7 cells.
作 者：Shie PH, Wang SY, Lay HL, Huang GJ
出 版 年：2016
分 類：抗發炎
論文結論：4,7-dimethoxy-5-methyl-1,3-benzodioxole (DMB), one of the major benzenoid compounds isolated from the mycelia of Antrodia camphorata, may have therapeutic potential for the treatment of inflammatory diseases.
論文出處：Appl Microbiol Biotechnol. 2016 May;100(10):4385-93. doi: 10.1007/s00253-015-7260-3. Epub 2016 Jan 8.
論文名稱：Comparative characterization of physicochemical properties and bioactivities of polysaccharides from selected medicinal mushrooms.
作 者：Su CH, Lai MN, Lin CC, Ng LT
出 版 年：2016
分 類：抗發炎
論文結論：The monosaccharide composition of polysaccharides varied between different mushrooms, and glucose was the predominant monosaccharide, followed by galactose and mannose. Polysaccharides of Antrodia cinnamomea (AC-P) and Grifola frondosa (GF-P) contained the highest amount of (1,3;1,6)-β-D-glucans. These polysaccharides showed inhibitory potency on NO production in LPS-stimulated RAW264.7 cells.
論文出處：PLoS One. 2016 Apr 5;11(4):e0153087. doi: 10.1371/journal.pone.0153087. eCollection 2016.
論文名稱：Hepatoprotective Effect of Wheat-Based Solid-State Fermented Antrodia cinnamomea in Carbon Tetrachloride-Induced Liver Injury in Rat.
作 者：Chiu HW, Hua KF
出 版 年：2016
分 類：抗發炎
論文結論：WFAC is a nontoxic hepatoprotective agent against chronic CCl4-induced hepatic injury.
論文出處：Innate Immun. 2016 Oct;22(7):522-33. doi: 10.1177/1753425916661402. Epub 2016 Jul 28.
論文名稱：Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity.
作 者：Lu CC, Hsu YJ, Chang CJ, Lin CS, Martel J, Ojcius DM, Ko YF, Lai HC, Young JD
出 版 年：2016
分 類：抗發炎
論文結論：Water and ethanol extracts of cultured mycelium from Antrodia cinnamomea may determine the nature of the immunomodulatory effects produced on immune cells, presumably owing to the differential solubility of stimulatory and inhibitory mediators.
論文出處：Process Biochemistry Volume 51, Issue 8, August 2016, Pages 941-949. https://doi.org/10.1016/j.procbio.2016.05.001
論文名稱：Precursor-feeding strategy on the triterpenoid production and anti-inflammatory activity of Antrodia cinnamomea
作 者：Chen YT, Shen YC, Chang MC, Lu MK
出 版 年：2016
分 類：抗發炎
論文結論：
Antrodia cinnamomea inhibited LPS-induced NO, iNOS and COX-2 expression in BV-2 cells.
論文出處：Food Hydrocolloids Volume 53, February 2016, Pages 37-45. https://doi.org/10.1016/j.foodhyd.2014.09.035
論文名稱：Studies on anti-inflammatory activity of sulfated polysaccharides from cultivated fungi Antrodia cinnamomea
作 者：Cheng JJ, Chao CH, Chang PC, Lu MK
出 版 年：2016
分 類：抗發炎
論文結論：
Polysaccharides (PSs) and sulfated polysaccharides (SPSs) were isolated from the mycelia of Antrodia cinnamomea. SPSs showed a stronger inhibitory effect on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) release compared to those of non-sulfated polysaccharide (PS).
論文出處：J Ethnopharmacol. 2015 Jan 15;159:113-21. doi: 10.1016/j.jep.2014.11.015. Epub 2014 Nov 18.
論文名稱：Anti-inflammatory effects of Antrodia camphorata, a herbal medicine, in a mouse skin ischemia model.
作 者：Tsai TC, Tung YT, Kuo YH, Liao JW, Tsai HC, Chong KY, Chen HL, Chen CM
出 版 年：2015
分 類：抗發炎
論文結論：Methanolic extracts of wood-cultured fruiting bodies and solid-state-cultured mycelia from Antrodia camphorata and its active compound, ergostatrien-3β-ol (ST1) have anti-inflammatory activities.
論文出處：BMC Complement Altern Med. 2015 Jul 16;15:237. doi: 10.1186/s12906-015-0768-3.
論文名稱：Effects of Antrodia camphorata extracts on anti-oxidation, anti-mutagenesis and protection of DNA against hydroxyl radical damage.
作 者：Hsieh YL, Wu SP, Fang LW, Hwang TS
出 版 年：2015
分 類：抗發炎
論文結論：Antrodia camphorata is a non-toxic and novel material with antioxidant, antimutagenic and DNA-protective activities. That reducing and scavenging activities against superoxide anion radical and also exhibited protective effects on DNA against hydroxyl radical-induced damage.
論文出處：Bioorg Med Chem Lett. 2015 Oct 15;25(20):4637-41. doi: 10.1016/j.bmcl.2015.08.038. Epub 2015 Aug 20.
論文名稱：Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity response.
作 者：Lin MK, Lee MS, Chang WT, Chen HY, Chen JF, Li YR, Lin CC, Wu TS
出 版 年：2015
分 類：抗發炎
論文結論：Zhankuic acid C (ZAC), a ergostane triterpenoids from Taiwanofungus camphoratus, exhibits an immunosuppressive effect on dendritic cells (DC) activation and the contact hypersensitivity response in mice. That ZAC can potentially be used for treating chronic inflammation and autoimmune diseases.
論文出處：PLoS One. 2015 Feb 27;10(2):e0116191. doi: 10.1371/journal.pone.0116191. eCollection 2015.
論文名稱：The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines.
作 者：Lin CC, Pan IH, Li YR, Pan YG, Lin MK, Lu YH, Wu HC, Chu CL
出 版 年：2015
分 類：抗發炎
論文結論：The water extract of Antrodia cinnamomea high-molecular weight polysaccharides (AC hmwPSs) promoted pro-inflammatory cytokine production by dendritic cells (DCs) and the maturation of DCs. DC-induced antigen-specific T cell activation and Th1 differentiation were increased by AC hmwPSs.
論文出處：Am J Chin Med. 2015;43(7):1401-17. doi: 10.1142/S0192415X15500792. Epub 2015 Oct 18.
論文名稱：Antrodia cinnamomea Extract Inhibits Th17 Cell Differentiation and Ameliorates Imiquimod-Induced Psoriasiform Skin Inflammation.
作 者：Li MH, Wu HC, Yao HJ, Lin CC, Wen SF, Pan IH
出 版 年：2015
分 類：抗發炎
論文結論：Antrodia cinnamomea extract (AC) inhibited the differentiation of Th17 cells as well as the production of IL-17A, IL-21, and IL-22 from these cells. This effect was associated with the inhibition of STAT3 phosphorylation and RORγt expression.
論文出處：J Agric Food Chem. 2014 Jun 11;62(23):5321-9. doi: 10.1021/jf405113g. Epub 2014 May 29.
論文名稱：Methanol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-κB and MAPK pathways in mice.
作 者：Huang GJ, Deng JS, Chen CC, Huang CJ, Sung PJ, Huang SS, Kuo YH.
出 版 年：2014
分 類：抗發炎
論文結論：Pretreatment with the methanol extract of Antrodia camphorata (MAC) markedly improved LPS-induced histological alterations and edema in lung tissues. Utilize the NF-κB and MAPKs pathways and the regulation of SOD activity to attenuate LPS-induced nonspecific pulmonary inflammation.
論文出處：Int J Med Mushrooms. 2014;16(1):95-103.
論文名稱：Immunomodulatory effect of polysaccharides extracted from the medicinal mushroom Antrodia camphorata (higher Basidiomycetes) in specific pathogen-free chickens.
作 者：Song AR, Qin D, Zhao C, Sun XL, Huang F, Kong C, Yang S
出 版 年：2014
分 類：抗發炎
論文結論：Antrodia camphorata extract (ACE) could enhance the immune functions of the organs in specific pathogen-free (SPF) chickens and could be an attractive application of nutraceuticals and pharmaceuticals.
論文出處：Phytomedicine. 2014 Oct 15;21(12):1708-16. doi: 10.1016/j.phymed.2014.08.011. Epub 2014 Sep 16.
論文名稱：Comparison of solid-state-cultured and wood-cultured Antrodia camphorata in anti-inflammatory effects using NF-κB/luciferase inducible transgenic mice.
作 者：Tung YT, Tsai TC, Kuo YH, Yen CC, Sun JY, Chang WH, Chen HL, Chen CM
出 版 年：2014
分 類：抗發炎
論文結論：Methanolic extracts both of solid-state-cultured AC (S-AC) and wood-cultured AC (W-AC) have excellent anti-inflammatory activities.
論文出處：ScientificWorldJournal. 2014;2014:745802. doi: 10.1155/2014/745802. Epub 2014 Oct 14.
論文名稱：Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C.
作 者：Lu WJ, Lin SC, Lan CC, Lee TY, Hsia CH, Huang YK, Lee HC, Sheu JR
出 版 年：2014
分 類：抗發炎
論文結論：Antrodia camphorata may inhibit platelet activation by inhibiting of Ca2+ and PKC cascade and the Akt pathway. That may be a potential therapeutic agent for preventing or treating thromboembolic disorders.
論文出處：J Immunol. 2014 Mar 15;192(6):2778-86. doi: 10.4049/jimmunol.1301931. Epub 2014 Feb 14.
論文名稱：Zhankuic acid A isolated from Taiwanofungus camphoratus is a novel selective TLR4/MD-2 antagonist with anti-inflammatory properties.
作 者：Chen YF, Shiau AL, Wang SH, Yang JS, Chang SJ, Wu CL, Wu TS.
出 版 年：2014
分 類：抗發炎
論文結論：Zhankuic acid A (ZAA), a major pharmacologically active compound of Taiwanofungus camphoratus, which can compete with LPS for binding to MD-2 as a TLR4/MD-2 antagonist, may be a potential therapeutic agent for gram-negative bacterial infections.
論文出處：Biochem Pharmacol. 2014 Sep 15;91(2):217-30. doi: 10.1016/j.bcp.2014.06.026. Epub 2014 Jul 27.
論文名稱：Zhankuic acid A as a novel JAK2 inhibitor for the treatment of concanavalin A-induced hepatitis.
作 者：Chen YF, Wang SH, Chang SJ, Shiau AL, Her LS, Shieh GS, Chen CF, Chang CC, Su YC, Wu CL, Wu TS
出 版 年：2014
分 類：抗發炎
論文結論：Zhankuic acid A (ZAA), a major pharmacologically active compound, can inhibit JAK2 phosphorylation and protect against liver injury during acute hepatitis in mice.
論文出處：PLoS One. 2014 Apr 1;9(4):e93191. doi: 10.1371/journal.pone.0093191. eCollection 2014.
論文名稱：Hepatoprotective bioactivity of the glycoprotein, antrodan, isolated from Antrodia cinnamomea mycelia.
作 者：Ker YB, Peng CC, Chang WL, Chyau CC, Peng RY
出 版 年：2014
分 類：抗發炎
論文結論：Antrodan, a polysaccharide isolated from mycelia of Antrodia cinnamomea, can potentially ameliorate liver damage in vivo by suppressing oxidative stress induced by LPS.
論文出處：Int J Radiat Biol. 2014 Oct;90(10):841-52. doi: 10.3109/09553002.2014.911989. Epub 2014 Aug 11.
論文名稱：Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells.
作 者：Cheng PC, Huang CC, Chiang PF, Lin CN, Li LL, Lee TW, Lin B, Chen IC, Chang KW, Fan CK, Luo TY.
出 版 年：2014
分 類：抗發炎
論文結論：Antrodia cinnamomea (AC) may inhibit important immunoregulatory signaling which could be vital in the avoidance of an over-activated cytotoxic and inflammatory response of the immune system caused by radiation-induced tissue damage. AC does not provide a radioprotective effect to tumor cells but instead enhances radiation-induced inflammation and cytotoxicity in cancer.
論文出處：Food Chem Toxicol. 2014 Jul;69:150-62. doi: 10.1016/j.fct.2014.04.006. Epub 2014 Apr 18.
論文名稱：Antrodia cinnamomea profoundly exalted the reversion of activated hepatic stellate cells by the alteration of cellular proteins.
作 者：Chen YR, Chang KT, Tsai MJ, Lee CH, Huang KJ, Cheng H, Ho YP, Chen JC, Yang HH, Weng CF
出 版 年：2014
分 類：抗發炎
論文結論：Antrodia cinnamomea mycelial extract (ACME) could improve liver morphology and histological changes including collagen formation and GPT activity in the liver of thioacetamide (TAA)-injured rats.
論文出處：J Ethnopharmacol. 2014 Aug 8;155(1):154-64. doi: 10.1016/j.jep.2014.04.053. Epub 2014 May 20.
論文名稱：The medicinal fungus Antrodia cinnamomea suppresses inflammation by inhibiting the NLRP3 inflammasome.
作 者：Huang TT, Wu SP, Chong KY, Ojcius DM, Ko YF, Wu YH, Wu CY, Lu CC, Martel J, Young JD, Lai HC
出 版 年：2014
分 類：抗發炎
論文結論：Antrodia cinnamomea ethanol extract (ACEE) suppresses the secretion of IL-1β and IL-18 associated with inhibition of the NLRP3 inflammasome in macrophages, have therapeutic potential for the treatment of inflammatory diseases.
論文出處：China journal of Chinese materia medica. 2014 May;39(9):1670-4.
論文名稱：[Effect of Antrodia cinnamomea on gene expression related to aortal endothelial injury in rats with hyperlipidemia].
[Article in Chinese]
作 者：Qi J, Tao Y, Zhang J, Fu J.
出 版 年：2014
分 類：抗發炎
論文結論：Antrodia cinnamomea can alleviate endothelial lipid injury by inhibiting the expressions of LOX-1, P38MAPK and NF-kappaB in aorta and better protect aortal endothelial cells from oxidative lipid injury.
論文出處：Int J Mol Sci. 2013 Feb 26;14(3):4629-39. doi: 10.3390/ijms14034629.
論文名稱：New Anti-Inflammatory Aromatic Components from Antrodia camphorata.
作 者：Chen YC, Chiu HL, Chao CY, Lin WH, Chao LK, Huang GJ, Kuo YH.
出 版 年：2013
分 類：抗發炎
論文結論：Five benzenoids were isolated from Antrodia camphorata. That potently inhibited LPS (lipopolysaccharide)-induced nitric oxide (NO) production.
論文出處：J Agric Food Chem. 2013 May 29;61(21):5064-71. doi: 10.1021/jf303820k. Epub 2013 May 16.
論文名稱：Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice.
作 者：Deng JS, Huang SS, Lin TH, Lee MM, Kuo CC, Sung PJ, Hou WC, Huang GJ, Kuo YH.
出 版 年：2013
分 類：抗發炎
論文結論：The anti-inflammatory mechanisms of Eburicoic acid (TR1) and dehydroeburicoic acid (TR2) might be related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity.
論文出處：J Nat Prod. 2013 Apr 26;76(4):489-94. doi: 10.1021/np300443p. Epub 2013 Mar 21.
論文名稱：Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata.
作 者：Liaw CC, Chen YC, Huang GJ, Tsai YC, Chien SC, Wu JH, Wang SY, Chao LK, Sung PJ, Huang HC, Kuo YH.
出 版 年：2013
分 類：抗發炎
論文結論：Four new lanostanoids and two new lactone derivatives, with four known compounds, were characterized from Antrodia camphorata. Ethyl lucidenate A, 15-O-acetylganolucidate A, 11α-hydroxy-3,7-dioxolanost-8,24(E)-dien-26- oic acid, 3,7,11-trioxo-5α-lanosta-8,24(E)-dien-26-oic acid, methyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, and ethyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate significantly suppressed the NO concentration in LPS-treated RAW 264.7 cells.
論文出處：Free Radic Biol Med. 2013 Aug;61:285-97. doi: 10.1016/j.freeradbiomed.2013.03.024. Epub 2013 Apr 6.
論文名稱：Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome.
作 者：Yang SM, Ka SM, Hua KF, Wu TH, Chuang YP, Lin YW, Yang FL, Wu SH, Yang SS, Lin SH, Chang JM, Chen A.
出 版 年：2013
分 類：抗發炎
論文結論：Antroquinonol administration substantially impeded the development of severe renal lesions (glomerular proliferation, crescents, sclerosis, and periglomerular interstitial inflammation), in mice with induced accelerated and progressive IgA nephropathy (AcP-IgAN).
論文出處：Evid Based Complement Alternat Med. 2013;2013:914524. doi: 10.1155/2013/914524. Epub 2013 May 30.
論文名稱：Ethanol Extract of Antrodia camphorata Grown on Germinated Brown Rice Suppresses Inflammatory Responses in Mice with Acute DSS-Induced Colitis.
作 者：Park DK, Park HJ.
出 版 年：2013
分 類：抗發炎
論文結論：The anti-inflammatory activity of Antrodia camphorata (AC) grown on germinated brown rice (CBR) is a promising, potential agent for preventing acute colitis through the inhibition of NF-κB signaling and its upstream signaling molecules, including MAPKs.
論文出處：Food Chem. 2013 Dec 1;141(3):3020-7. doi: 10.1016/j.foodchem.2013.03.061. Epub 2013 Apr 6.
論文名稱：Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.
作 者：Huang GJ, Deng JS, Huang SS, Lee CY, Hou WC, Wang SY, Sung PJ, Kuo YH.
出 版 年：2013
分 類：抗發炎
論文結論：Eburicoic acid (TR1) and dehydroeburicoic acid (TR2) protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms.
論文出處：Appl Microbiol Biotechnol. 2013 Dec;97(23):9955-67. doi: 10.1007/s00253-013-5214-1. Epub 2013 Sep 24.
論文名稱：Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis.
作 者：Wang LC, Kuo IU, Tsai TY, Lee CL.
出 版 年：2013
分 類：抗發炎
論文結論：Antrodia camphorata-fermented product cultured in Deep ocean water (DOW-AC) prevented from thioacetamide (TAA)-induced weight loss and had more effect on inhibiting lipid peroxidation, reactive oxygen species, iNOS, and TNF-α expression. DOW-AC increased the production of Antrodia camphorata-fermented functional metabolites (triterpenoids, polysaccharides, flavonoids, and polyphenols) and had more potent effect on protection against TAA-induced liver damage and fibrosis.
論文出處：Chem Biodivers. 2013 Mar;10(3):434-41. doi: 10.1002/cbdv.201200258.
論文名稱：Inhibitory effects of maleimide derivatives from the mycelia of the fungus Antrodia cinnamomea BCRC 36799 on nitric oxide production in lipopolysaccharide (LPS)-activated RAW264.7 macrophages.
作 者：Wu MD, Cheng MJ, Yech YJ, Yuan GF, Chen JJ.
出 版 年：2013
分 類：抗發炎
論文結論：Four new maleimide derivatives, antrocinnamomins E-H, with (3S,4R)-1-hydroxy-3-(4-hydroxyphenyl)-4-(2-methylpropyl)pyrrolidine-2,5-dione and ergosterol were isolated from the mycelia of Antrodia cinnamomea BCRC 36799. Antrocinnamomins F and H showed stronger inhibition of NO production.
論文出處：Phytomedicine. 2013 Jul 15;20(10):874-82. doi: 10.1016/j.phymed.2013.03.008. Epub 2013 Apr 20.
論文名稱：Elucidating the inhibitory mechanisms of the ethanolic extract of the fruiting body of the mushroom Antrodia cinnamomea on the proliferation and migration of murine leukemia WEHI-3 cells and their tumorigenicity in a BALB/c allograft tumor model.
作 者：Liu FC, Lai MT, Chen YY, Lin WH, Chang SJ, Sheu MJ, Wu CH.
出 版 年：2013
分 類：抗發炎
論文結論：Ethanolic extract of Antrodia cinnamomea (EEAC) inhibited the proliferation and reduced the migration of WEHI-3 cells, resulting in the accumulation of cell in G0/G1 and G2/M phases in vitro. And the ability of EEAC to reduced infiltration of WEHI-3 cells into the liver and spleen in vivo.
論文出處：J Agric Food Chem. 2013 Sep 11;61(36):8556-64. doi: 10.1021/jf402849b. Epub 2013 Aug 30.
論文名稱：Establishment of the metabolite profile for an Antrodia cinnamomea health food product and investigation of its chemoprevention activity.
作 者：Wang HC, Chu FH, Chien SC, Liao JW, Hsieh HW, Li WH, Lin CC, Shaw JF, Kuo YH, Wang SY.
出 版 年：2013
分 類：抗發炎
論文結論：4-Acetylantroquinonol B obtained from ethanolic extract ofAntrodia cinnamomea mycelium (EMAC), was able to not only inhibit LPS-induced nitric oxide formation in macrophages but also protect against ethanol-induced oxidative stress in liver cells. And significantly reduced liver inflammation and serum oxidative stress in vivo.
論文出處：Molecules. 2013 Dec 19;19(1):22-40. doi: 10.3390/molecules19010022.
論文名稱：Physicochemical characteristics and anti-inflammatory activities of antrodan, a novel glycoprotein isolated from Antrodia cinnamomea mycelia.
作 者：Chiu CH, Peng CC, Ker YB, Chen CC, Lee A, Chang WL, Chyau CC, Peng RY
出 版 年：2013
分 類：抗發炎
論文結論：Antrodan, a novel polysaccharide obtained from mycelia of Antrodia cinnamomea, was characterized as a glycoprotein. It showed potent suppressing effect on the lipopolysaccharide-induced inflammatory responses in RAW 264.7 cell line. And reduced the nitrogen oxide production.
論文出處：Arthritis Rheum. 2012 Jan;64(1):232-42. doi: 10.1002/art.33328.
論文名稱：Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis.
作 者：Tsai PY, Ka SM, Chang JM, Lai JH, Dai MS, Jheng HL, Kuo MT, Chen P, Chen A.
出 版 年：2012
分 類：抗發炎
論文結論：Antroquinonol, a purified compound of Antrodia camphorata, may have therapeutic potential for the early treatment of accelerated severe lupus nephritis (ASLN) via its differential regulation of T cell function and lowering of IL-18 production, but also via the promotion of Nrf2 activation.
論文出處：J Pharm Biomed Anal. 2012 Jan 25;58:182-92. doi: 10.1016/j.jpba.2011.09.007. Epub 2011 Sep 16.
論文名稱：Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata.
作 者：Du YC, Wu TY, Chang FR, Lin WY, Hsu YM, Cheng FT, Lu CY, Yen MH, Tsui YT, Chen HL, Hou MF, Lu MC, Wu YC.
出 版 年：2012
分 類：抗發炎
論文結論：A method for concentrating the antiproliferative active triterpenoid-rich fraction (FEA), from ethanolic extract of AC (EEAC). Eight ergostanes and two lanostanes were characterised by high-performance liquid chromatography-photodiode array detection/mass spectrometry (HPLC-PDA/MS).Eight ergostanes and their pair mixture forms (antcin K, antcin C, zhankuic acid C, and zhankuic acid A) were subjected to anti-proliferative assay against three human leukemia cell lines (CCRF-CEM, Molt 4 and HL 60).
論文出處：Nutrition. 2012 Sep;28(9):942-9. doi: 10.1016/j.nut.2012.01.006. Epub 2012 Apr 26.
論文名稱：Polysaccharides from extracts of Antrodia camphorata mycelia and fruiting bodies modulate inflammatory mediator expression in mice with polymicrobial sepsis.
作 者：Meng LM, Pai MH, Liu JJ, Yeh SL.
出 版 年：2012
分 類：抗發炎
論文結論：The polysaccharides contained within Antrodia camphorata (AC-PSs) from mycelia or fruiting bodies decreased the inflammatory mediator expressions at the location of injury and in the circulation, especially in the late stage of sepsis. From fruiting bodies seemed to be more effective in decreasing the inflammatory response than those from mycelia.
論文出處：Int J Med Mushrooms. 2012;14(3):241-56.
論文名稱：Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes).
作 者：Yue PY, Wong YY, Chan TY, Law CK, Tsoi YK, Leung KS
出 版 年：2012
分 類：抗發炎
論文結論：Summarizes the latest published results from Antrodia camphorata research, focusing on the biological and pharmacological activities of the crude extract compounds (Including polysaccharides, terpenoids, steroids, lignans, benzoquinone derivatives, benzenoids, and maleic and succinic acid derivatives) and their functions (such as anti-hypertensive, anti-hyperlipidemic, anti-inflammatory, anti-oxidant, anti-tumor, and immuno-modulatory activities).
論文出處：Am J Chin Med. 2012;40(5):953-65. doi: 10.1142/S0192415X1250070X.
論文名稱：Inhibition of Na(+)/K(+) -ATPase by antcins, unique steroid-like compounds in Antrodia camphorate.
作 者：Chung TY, Li FY, Chang CI, Jinn TR, Tzen JT.
出 版 年：2012
分 類：抗發炎
論文結論：Five steroid compounds, antcin A, B, C, H, and K were isolated from Antrodia camphorata, and all inhibited Na(+)/K(+) -ATPase. Antcin A exhibited significantly higher inhibitory potency than the other four antcins, is a bi-functional compound that exerts anti-inflammatory effects and that enhances blood circulation.
論文出處：J Tradit Complement Med. 2012 Apr;2(2):84-95.
論文名稱：Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine.
作 者：Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H
出 版 年：2012
分 類：抗發炎
論文結論：This review focus on the active constituents of the herbs (Taiwanofungus camphoratus) and their bioactivities, with emphasis on the most recent progress in research for the period of 2003 to 2011.
論文出處：Phytomedicine. 2012 Mar 15;19(5):424-35. doi: 10.1016/j.phymed.2011.11.003. Epub 2012 Jan 30.
論文名稱：Methanol extract of Antrodia cinnamomea mycelia induces phenotypic and functional differentiation of HL60 into monocyte-like cells via an ERK/CEBP-β signaling pathway.
作 者：Wen CL, Teng CL, Chiang CH, Chang CC, Hwang WL, Kuo CL, Hsu SL.
出 版 年：2012
分 類：抗發炎
論文結論：Methanol extract of liquid cultured mycelia of Antrodia cinnamomea (MEMAC) inhibited proliferation and induced G1-phase cell cycle arrest in HL60 cells, and their monocytic differentiation is via the activating ERK signaling pathway, and downstream upregulating the transcription factor C/EBPβ and differentiation marker CD14 gene.
論文出處：Nat Prod Res. 2011 Apr;25(7):684-95. doi: 10.1080/14786410802525487. Epub 2010 Jul 9.
論文名稱：Further studies on the hepatoprotective effect of Antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats.
作 者：Lu ZM, Tao WY, Xu HY, Ao ZH, Zhang XM, Xu ZH.
出 版 年：2011
分 類：抗發炎
論文結論：The ethanolic extract (Fr-I) of Antrodia camphorata was the most effective in the prevention of ethanol-induced acute liver injury and free radical generation in rats.
論文出處：ree Radic Biol Med. 2011 Jun 1;50(11):1503-16. doi: 10.1016/j.freeradbiomed.2011.02.029. Epub 2011 Mar 2.
論文名稱：Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice.
作 者：Tsai PY, Ka SM, Chao TK, Chang JM, Lin SH, Li CY, Kuo MT, Chen P, Chen A.
出 版 年：2011
分 類：抗發炎
論文結論：Antroquinonol is an active component by Antrodia camphorata, that might a therapeutic agent for focal segmental glomerulosclerosis (FSGS), acting by boosting Nrf2 activation and suppressing NF-κB-dependent inflammatory and TGF-β1-mediated fibrosis pathways in the kidney in a mice model.
論文出處：J Agric Food Chem. 2011 Apr 27;59(8):4248-54. doi: 10.1021/jf104561h. Epub 2011 Mar 14.
論文名稱：Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol.
作 者：Wu MT, Tzang BS, Chang YY, Chiu CH, Kang WY, Huang CH, Chen YC.
出 版 年：2011
分 類：抗發炎
論文結論：Antrodia camphorata could lower liver damage in rats chronically fed alcohol.
論文出處：Biosci Biotechnol Biochem. 2011;75(4):624-32. Epub 2011 Apr 22.
論文名稱：Macrophage mediated anti-proliferation effects of Anthodia camphorata non-polysaccharide based extracts on human hepatoma cells.
作 者：Chang CY, Cheng TJ, Chang FR, Wang HY, Kan WC, Li SL, Huang LH, Chen YC, Tsai WC, Huang CH, Cheng CH, Lee GY, Shyue SW, Chen YP, Lin KC, Chuu JJ.
出 版 年：2011
分 類：抗發炎
論文結論：Two of the extracts (extracts of Anthodia camphorata from fruiting bodies, AC-FB and from mycelium of solid-state cultures, AC-SS) had better anti-proliferation effects, implying that the macrophages might play an immunomodulatory role.
論文出處：Acta Pharmacol Sin. 2011 Jul;32(7):904-11. doi: 10.1038/aps.2011.36. Epub 2011 May 23.
論文名稱：Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids.
作 者：Chen YC, Liu YL, Li FY, Chang CI, Wang SY, Lee KY, Li SL, Chen YP, Jinn TR, Tzen JT.
出 版 年：2011
分 類：抗發炎
論文結論：Five major antcins (A, B, C, H, and K) were isolated from fruiting bodies of Antrodia camphorata. The anti-inflammatory effect of Antrodia camphorata is, at least, partly attributed to antcin A that mimics glucocorticoids and triggers translocation of glucocorticoid receptor into nucleus to initiate the suppressing inflammation.
論文出處：Acta Pharmacol Sin. 2011 Aug; 32(8): 981–982. Published online 2011 Aug 5. doi: 10.1038/aps.2011.104
論文名稱：Antcin A contributs to anti-inflammatory effect of Niuchangchih (Antrodia camphorata).
作 者：Lu ZM, Xu ZH.
出 版 年：2011
分 類：抗發炎
論文結論：
Chen et al demonstrated in human lung cancer cell A549 that antcin A was the active ingredient responsible for the anti-inflammatory effect of Antrodia camphorata, which mechanism triggered by glucocorticoids4. Hsien et al recently showed another anti-inflammatory activity compound, antrocamphin A, from Antrodia camphorata, resulted from suppressing pro-inflammatory molecule release via down-regulation of iNOS and COX-2 expression through NF-κB pathway5. Both the studies provide the potential of Antrodia camphorata to treat inflammation.
論文出處：Bioorg Med Chem. 2011 Jan 1;19(1):677-83. doi: 10.1016/j.bmc.2010.10.032. Epub 2010 Oct 20.
論文名稱：Biologically active constituents from the fruiting body of Taiwanofungus camphoratus.
作 者：Shi LS, Chao CH, Shen DY, Chan HH, Chen CH, Liao YR, Wu SJ, Leu YL, Shen YC, Kuo YH, Lee EJ, Qian K, Wu TS, Lee KH.
出 版 年：2011
分 類：抗發炎
論文結論：Five new benzenoids, benzocamphorins A-E, and 10 recently isolated triterpenoids, camphoratins A-J, with 23 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. These compounds may use in traditional Chinese medicine (TCM) for the treatment of inflammation and cancer-related diseases.
論文出處：Nat Prod Res. 2011 Sep;25(16):1488-96. doi: 10.1080/14786410903132563. Epub 2011 Jul 8.
論文名稱：Antioxidant activities of extracts and metabolites isolated from the fungus Antrodia cinnamomea.
作 者：Wu MD, Cheng MJ, Wang WY, Huang HC, Yuan GF, Chen JJ, Chen IS, Wang BC.
出 版 年：2011
分 類：抗發炎
論文結論：N-hexane, ethyl acetate [EtOAc] and n-BuOH of the culture broth from Antrodia cinnamomea were assayed with 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and superoxide radical scavenging (SOD) assay. In EtOAc layer exhibited the best antioxidant activity, and isolated major antioxidant metabolites.
論文出處：J Ethnopharmacol. 2011 Sep 1;137(1):575-84. doi: 10.1016/j.jep.2011.06.009. Epub 2011 Jun 16.
論文名稱：Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo.
作 者：Wen CL, Chang CC, Huang SS, Kuo CL, Hsu SL, Deng JS, Huang GJ.
出 版 年：2011
分 類：抗發炎
論文結論：Methanol extract of liquid cultured mycelia of Antrodia cinnamomea (MEMAC) has the anti-inflammatory property both in vitro and in vivo.
論文出處： Immunology. 2010 Mar;129(3):351-62. doi: 10.1111/j.1365-2567.2009.03175.x. Epub 2009 Nov 11.
論文名稱：Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma.
作 者：Liu KJ, Leu SJ, Su CH, Chiang BL, Chen YL, Lee YL
出 版 年：2010
分 類：抗發炎
論文結論：A. camphorata polysaccharides (GF2) may have therapeutic potential when used as an adjuvant for the immunomodulatory treatment of allergic asthma.
論文出處：J Agric Food Chem. 2010 Mar 24;58(6):3859-66. doi: 10.1021/jf100530c.
論文名稱：Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage.
作 者：Huang CH, Chang YY, Liu CW, Kang WY, Lin YL, Chang HC, Chen YC
出 版 年：2010
分 類：抗發炎
論文結論：High dosage Antrodia camphorata showed a hypercholesterolemic effect and reduced hepatic lipids in alcohol-fed rats.
論文出處：Cancer Immunol Immunother. 2010 Aug;59(8):1259-72. doi: 10.1007/s00262-010-0852-y.
論文名稱：Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine.
作 者：Huang CH, Chang CC, Lin CM, Wang ST, Wu MT, Li EI, Chang HC, Lin CC.
出 版 年：2010
分 類：抗發炎
論文結論：Antrodia camphorata represents a promising immunomodulatory adjuvant. Compared with the mice that received the HER-2/neu DNA vaccine alone, co-treatment with AC suppressed tumor growth and extended the survival rate.
論文出處：J Agric Food Chem. 2010 Jun 23;58(12):7445-52. doi: 10.1021/jf1013764.
論文名稱：Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice.
作 者：Huang GJ, Huang SS, Lin SS, Shao YY, Chen CC, Hou WC, Kuo YH.
出 版 年：2010
分 類：抗發炎
論文結論：An active ingredient from Antrodia camphorata (AC), Ergostatrien-3beta-ol (ST1), that anti-inflammatory mechanisms might be related to the decrease in the level of MDA, iNOS, and COX-2 in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver through the suppression of TNF-alpha and NO.
論文出處：Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2319-25. doi: 10.1016/j.fct.2010.05.066. Epub 2010 Jun 1.
論文名稱：Antrodia camphorata suppresses lipopolysaccharide-induced nuclear factor-kappaB activation in transgenic mice evaluated by bioluminescence imaging.
作 者：Hseu YC, Huang HC, Hsiang CY.
出 版 年：2010
分 類：抗發炎
論文結論：The anti-inflammatory action in vivo of fermented culture broth of Antrodia camphorata in terms of LPS-induced NF-kappaB activation in transgenic mice.
論文出處：Bioorg Med Chem. 2010 Sep 15;18(18):6896-904. doi: 10.1016/j.bmc.2010.07.024. Epub 2010 Jul 16.
論文名稱：Structure and functions of gamma-dodecalactone isolated from Antrodia camphorata for NK cell activation.
作 者：Chen CJ, Vijaya Krishna R, Tsai CC, Wu WH, Chao LK, Hwang KH, Chien CM, Chang HY, Chen ST.
出 版 年：2010
分 類：抗發炎
論文結論：A volatile compound, gamma-dodecalactone (gamma-DDL), was isolated from the culture medium of Antrodia camphorata. The gamma-DDL not only can induce NK cells to express CD69 but also stimulate NK cells to secrete cytotoxic molecules (FasL and granzyme B) and Th1 cytokines (TNF-alpha and INF-gamma).
論文出處：Nutr Cancer. 2010;62(5):593-600. doi: 10.1080/01635580903532341.
論文名稱：Dietary effect of Antrodia Camphorate extracts on immune responses in WEHI-3 leukemia BALB/c mice.
作 者：Lin SY, Sheen LY, Chiang BH, Yang JS, Pan JH, Chang YH, Hsu YM, Chiang JH, Lu CC, Wu CL, Chung JG.
出 版 年：2010
分 類：抗發炎
論文結論：Antrodia camphorata has ability to promote immune responses and to exhibited antileukemia activity in WEHI-3 leukemia BALB/c mice. And prolonged the survival rate and prevented the body weight loss.
論文出處：J Agric Food Chem. 2010 Mar 10;58(5):3153-8. doi: 10.1021/jf903638p.
論文名稱：Antrocamphin A, an anti-inflammatory principal from the fruiting body of Taiwanofungus camphoratus , and its mechanisms.
作 者：Hsieh YH, Chu FH, Wang YS, Chien SC, Chang ST, Shaw JF, Chen CY, Hsiao WW, Kuo YH, Wang SY.
出 版 年：2010
分 類：抗發炎
論文結論：The bioactive compound of Taiwanofungus camphoratus and illustrates the mechanism by which it confers its anti-inflammatory activity.
論文出處：J Nat Prod. 2010 Nov 29;73(11):1756-62. doi: 10.1021/np1002143. Epub 2010 Oct 28.
論文名稱：Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus.
作 者：Wu SJ, Leu YL, Chen CH, Chao CH, Shen DY, Chan HH, Lee EJ, Wu TS, Wang YH, Shen YC, Qian K, Bastow KF, Lee KH.
出 版 年：2010
分 類：抗發炎
論文結論：Ten new triterpenoids, camphoratins A-J, with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Have cytotoxicity against KB and KB-VIN human cancer cell lines. And exhibited anti-inflammatory NO-production inhibition activity.
論文出處：Planta Med. 2009 Apr;75(5):512-6. doi: 10.1055/s-0029-1185305. Epub 2009 Feb 2.
論文名稱：New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata.
作 者：Yang SS, Wang GJ, Wang SY, Lin YY, Kuo YH, Lee TH.
出 版 年：2009
分 類：抗發炎
論文結論：
Five compounds from mycelium of Antrodia camphorata were isolated by the guidance of an inducible nitric oxide synthase (iNOS) inhibitory assay analysis.
1. 2,4-dimethoxy-6-methylbenzene-1,3-diol and antrodin D significantly inhibited NO production without any cytotoxicity.
2. Antroquinonol B and 4-acetyl-antroquinonol B possessed greater effects on NO inhibition, but displayed cytotoxicity at considerably higher concentrations.
3. 2,3-(methylenedioxy)-6-methylbenzene-1,4-diol showed the lowest cell viability in treated cells.
論文出處：Int Heart J. 2009 Mar;50(2):207-20.
論文名稱：A novel inhibitory effect of Antrodia camphorata extract on vascular smooth muscle cell migration and neointima formation in mice.
作 者：Li YH, Chung HC, Liu SL, Chao TH, Chen JC
出 版 年：2009
分 類：抗發炎
論文結論：Antrodia camphorata (AC) is an effective inhibitor of platelet-derived growth factor (PDGF)-induced rat aortic smooth muscle cell (RASMC) proliferation and migration. AC treatment reduced neointima formation in this mouse carotid ligation model.
論文出處：Phytother Res. 2009 Apr;23(4):582-4. doi: 10.1002/ptr.2657.
論文名稱：Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease.
作 者：Phuong do T, Ma CM, Hattori M, Jin JS.
出 版 年：2009
分 類：抗發炎
論文結論：Antrodin A, a succinic acid constituents isolated from Antrodia cinnamomea, have inhibitory activity on hepatitis C virus (HCV) protease. And was also detected as an in vivo metabolite of the major constituent antrodin C.
論文出處：J Ethnopharmacol. 2009 Jun 25;123(3):407-12. doi: 10.1016/j.jep.2009.03.034. Epub 2009 Mar 31.
論文名稱：Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weights.
作 者：Yang CM, Zhou YJ, Wang RJ, Hu ML.
出 版 年：2009
分 類：抗發炎
論文結論：Polysaccharides from mycelia of Antrodia cinnamomea (PMAC) are anti-angiogenic in vitro and ex vivo, and the effects are likely through immunomodulation.
論文出處：Eur J Immunol. 2009 Sep;39(9):2482-91. doi: 10.1002/eji.200839039.
論文名稱：A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation.
作 者：Yu YL, Chen IH, Shen KY, Huang RY, Wang WR, Chou CJ, Chang TT, Chu CL.
出 版 年：2009
分 類：抗發炎
論文結論：Methyl antcinate K (me-AntK), A triterpenoid isolated from Antrodia cinnamomea, promote the ability of Dendritic cells (DC) to prime Th2 responses. And enhance immune responses and modulate DC function in immunotherapy.
論文出處：Toxicol Appl Pharmacol. 2008 Mar 1;227(2):291-8. Epub 2007 Nov 7.
論文名稱：In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni.
作 者：Cheng PC, Hsu CY, Chen CC, Lee KM.
出 版 年：2008
分 類：抗發炎
論文結論：The polysaccharides derived from Antrodia camphorata (AC-PS) appears to influence the immune system of mice into developing Th1 responses and have potential for preventing infection with Schistosoma mansoni.
論文出處：Int Immunopharmacol. 2008 Mar;8(3):458-67. doi: 10.1016/j.intimp.2007.11.008. Epub 2007 Dec 28.
論文名稱：Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.
作 者：hen YJ, Cheng PC, Lin CN, Liao HF, Chen YY, Chen CC, Lee KM
出 版 年：2008
分 類：抗發炎
論文結論：Antrodia camphorata polysaccharides (AC-PS) appears to modulate the immune system of mice and has potential for preventing Schistosoma mansoni infection.
論文出處：J Ethnopharmacol. 2008 Jul 23;118(2):237-45. doi: 10.1016/j.jep.2008.04.004. Epub 2008 Apr 12.
論文名稱：Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage.
作 者：Hseu YC, Chen SC, Yech YJ, Wang L, Yang HL
出 版 年：2008
分 類：抗發炎
論文結論：Antrodia camphorata possesses antioxidant properties and improves endothelial function, further offering effective protection from atherosclerosis.
論文出處：J Agric Food Chem. 2008 Aug 27;56(16):7017-22. doi: 10.1021/jf801171x. Epub 2008 Jul 19.
論文名稱：Anti-inflammatory activities of new succinic and maleic derivatives from the fruiting body of Antrodia camphorata.
作 者：Chien SC, Chen ML, Kuo HT, Tsai YC, Lin BF, Kuo YH
出 版 年：2008
分 類：抗發炎
論文結論：New compound, trans-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, increased spontaneous TNF-alpha secretion from unstimulated RAW264.7 cells but suppressed IL-6 production in LPS-stimulated cells. New compounds, cis-3-(4-hydroxyphenyl)-4-isobutyldihydrofuran-2,5-dione, 3-(4-hydroxyphenyl)-4-isobutyl-1H-pyrrole-2,5-dione, and dimethyl 2-(4-hydroxyphenyl)-3-isobutylmaleate, also suppressed IL-6 production, have an anti-inflammatory effect on macrophage-mediated responses.
論文出處：J Ethnopharmacol. 2008 Nov 20;120(2):196-203. doi: 10.1016/j.jep.2008.08.011. Epub 2008 Aug 19.
論文名稱：Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate.
作 者：Kuo MC, Chang CY, Cheng TL, Wu MJ
出 版 年：2008
分 類：抗發炎
論文結論：The mycelia fraction (Fr. M II) and culture filtrate fractions (Fr. E II and Fr. E III) were water extracts from Antrodia camphorata (AC), can modulate innate immunity and may serve as an adjuvant for tumor treatment.
論文出處：J Nat Prod. 2008 Jul;71(7):1258-61. doi: 10.1021/np070634k. Epub 2008 Jun 4.
論文名稱：Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages.
作 者：Wu MD, Cheng MJ, Wang BC, Yech YJ, Lai JT, Kuo YH, Yuan GF, Chen IS.
出 版 年：2008
分 類：抗發炎
論文結論：Two new maleimide derivatives, antrocinnamomins A and B, and two new maleic anhydride derivatives, antrocinnamomins C and D, with three known compounds, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrole-2,5-dione, and 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, were isolated from mycelium of Antrodia cinnamomea. Antrocinnamomins A displayed significant inhibitory effect on nitric oxide (NO) production.
論文出處：J Ethnopharmacol. 2007 Mar 1;110(1):160-4. Epub 2006 Oct 4.
論文名稱：Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats.
作 者：Lu ZM, Tao WY, Zou XL, Fu HZ, Ao ZH
出 版 年：2007
分 類：抗發炎
論文結論：Administration of Antrodia camphorata markedly prevented ethanol-induced elevation of levels of serum AST, ALT, ALP, and bilirubin comparable with standard drug silymarin in rats.
論文出處：Biosci Biotechnol Biochem. 2007 Jan;71(1):23-30. Epub 2007 Jan 7.
論文名稱：Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-chih) in spontaneously hypertensive rats.
作 者：Liu DZ, Liang YC, Lin SY, Lin YS, Wu WC, Hou WC, Su CH.
出 版 年：2007
分 類：抗發炎
論文結論：Methanol-soluble (MS) extracted of wild and solid-state cultures (SSC) of Antrodia camphorata exhibited angiotensin-converting enzyme (ACE) inhibitory activities and the antihypertensive effects. And was able to effectively lower the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of spontaneously hypertensive rats.
論文出處：Acta Pharmacol Sin. 2007 Feb;28(2):258-67.
論文名稱：Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata.
作 者：Wu YY, Chen CC, Chyau CC, Chung SY, Liu YW
出 版 年：2007
分 類：抗發炎
論文結論：Alkaline extraction-isoelectric precipitated the polysaccharide fraction (AC-2) of Antrodia camphorata and had the ability to inhibit LPS-induced iNOS, IL-6, IL-10, MCP-5, and RANTES expression in mouse macrophages.
論文出處：J Agric Food Chem. 2007 Jun 27;55(13):5007-12. Epub 2007 May 31.
論文名稱：Chemical characterization and anti-inflammatory effect of polysaccharides fractionated from submerge-cultured Antrodia camphorata mycelia.
作 者：Chen CC, Liu YW, Ker YB, Wu YY, Lai EY, Chyau CC, Hseu TH, Peng RY
出 版 年：2007
分 類：抗發炎
論文結論：
Five polysaccharide fractions (AC-1, AC-2, AC-3, AC-4, and AC-5) were obtained from Antrodia camphorata mycelia.
In the evaluation of the DPPH* radical scavenging capability, fraction AC-1 and AC-2 polysaccharides showed the better capabilities.
In testing with macrophage RAW264.7 cells, fraction AC-2 demonstrated a rather potent anti-inflammatory capability.
And the lipopolysaccharide-induced NO production and the protein expression by the inducible nitric oxide synthase (iNOS) gene were inhibited by fraction AC-2 polysaccharide.
論文出處：J Nat Prod. 2007 Jun;70(6):989-92. Epub 2007 Jun 9.
論文名稱：Anti-inflammatory benzenoids from Antrodia camphorata.
作 者：Chen JJ, Lin WJ, Liao CH, Shieh PC
出 版 年：2007
分 類：抗發炎
論文結論：Four new compounds (antrocamphin A (1), antrocamphin B (2), 2,3,4,5-tetramethoxybenzoyl chloride (3) and antrodioxolanone (4)) together with 13 known compounds (5~17) have been isolated from the fruiting body of Antrodia camphorata. Antrocamphin A (1), antcin A (10), and antcin B (11) exhibited potent inhibition against fMLP-induced superoxide production.
論文出處：J Ethnopharmacol. 2007 Aug 15;113(1):45-53. Epub 2007 May 18.
論文名稱：Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action.
作 者：Liu DZ, Liang HJ, Chen CH, Su CH, Lee TH, Huang CT, Hou WC, Lin SY, Zhong WB, Lin PJ, Hung LF, Liang YC.
出 版 年：2007
分 類：抗發炎
論文結論：EOC13.31 microglia was treated with various kinds of Antrodia camphorata extracts and lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) to evaluate the iNOS expression. And only methanol extracts from wild fruiting bodies were the most potent inhibitors of iNOS expression. The rank as follows: extracts of wild fruiting body>solid-state culture>liquid-state fermentation.
論文出處：Biosci Biotechnol Biochem. 2007 Aug;71(8):1873-8. Epub 2007 Aug 7.
論文名稱：DPPH radical scavenging and semicarbazide-sensitive amine oxidase inhibitory and cytotoxic activities of Taiwanofungus camphoratus (Chang-chih).
作 者：Wang GJ, Lin SY, Wu WC, Hou WC
出 版 年：2007
分 類：抗發炎
論文結論：Extracted with cold water, methanol, and hot water from Taiwanofungus camphoratus, all have DPPH radical scavenging, semicarbazide sensitive amine oxidase inhibitory, and cytotoxic activities in B16-F10 and HT-1080 cell lines.
論文出處：Am J Chin Med. 2006;34(2):217-31.
論文名稱：Antrodia camphorata in submerged culture protects low density lipoproteins against oxidative modification.
作 者：Yang HL, Hseu YC, Chen JY, Yech YJ, Lu FJ, Wang HH, Lin PS, Wang BC
出 版 年：2006
分 類：抗發炎
論文結論：The antioxidant properties of Antrodia camphorata may also provide effective protection from atherosclerosis.
論文出處：World J Gastroenterol. 2006 Apr 21;12(15):2369-74.
論文名稱：Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats.
作 者：Lin WC, Kuo SC, Lin WL, Fang HL, Wang BC
出 版 年：2006
分 類：抗發炎
論文結論：Filtrate of fermented mycelia from Antrodia camphorata (FMAC) can retard the progression of liver fibrosis induced by CCl(4) in rats.
論文出處：Chem Pharm Bull (Tokyo). 2006 Apr;54(4):496-500.
論文名稱：Protective effects of a neutral polysaccharide isolated from the mycelium of Antrodia cinnamomea on Propionibacterium acnes and lipopolysaccharide induced hepatic injury in mice.
作 者：Han HF, Nakamura N, Zuo F, Hirakawa A, Yokozawa T, Hattori M.
出 版 年：2006
分 類：抗發炎
論文結論：ACN2a, a neutral polysaccharide separated from the water extract mycelia of Antrodia cinnamomeawas, significantly prevented increases in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzyme activities in mice treated with Propionibacterium acnes-LPS, indicating hepatoprotective activity in vivo.
論文出處：J Agric Food Chem. 2005 Jan 26;53(2):469-74
論文名稱：Characterization and functional study of Antrodia camphorata lipopolysaccharide.
作 者：Cheng JJ, Yang CJ, Cheng CH, Wang YT, Huang NK, Lu MK
出 版 年：2005
分 類：抗發炎
論文結論：The functional structures and bioactivities of antrodia camphorata LPS were totally different from those of bacterial LPS. In contrary to the proinflammatory property of bacterial LPS, LPS from A. camphorata differentially reversed bacterial LPS-induced intercellular adhersion molecule-1 and monocyte adhesion; both were indicators during inflammatory process. Maybe LPS isolated from A. camphorata offers a novel therapeutic target for anti-inflammation against E. coli infection.
論文出處：Int Immunopharmacol. 2005 Dec;5(13-14):1914-25. Epub 2005 Jul 18.
論文名稱：Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway.
作 者：Hseu YC, Wu FY, Wu JJ, Chen JY, Chang WH, Lu FJ, Lai YC, Yang HL
出 版 年：2005
分 類：抗發炎
論文結論：Antrodia camphorata inhibits LPS induction of cytokine, iNOS and COX-2 expression by blocking NF-kappaB activation.
論文出處：FEMS Microbiol Lett. 2004 Feb 9;231(1):137-43.
論文名稱：Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species.
作 者：Shen YC, Chou CJ, Wang YH, Chen CF, Chou YC, Lu MK
出 版 年：2004
分 類：抗發炎
論文結論：Extracts from cultured mycelia of Antrodia camphorata display anti-inflammatory effects by inhibiting ROS production in human leukocytes at a pharmacologically applicable concentration. The biological activities of these extracts were further promoted when the culture medium was replaced with water-soluble fractions isolated from the wood of Cinnamomum micranthum (CM), Cinnamomum osmophloeum (CO) or Cinnamomum kotoense (CKO). And identified two lanostane-type compounds, dehydrosulfurenic acid and 15alpha-acetyl-dehydrosulfurenic acid, which could be involved in the anti-inflammatory actions of these extracts.
論文出處：Planta Med. 2004 Apr;70(4):310-4
論文名稱：Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata.
作 者：Shen YC, Wang YH, Chou YC, Chen CF, Lin LC, Chang TT, Tien JH, Chou CJ.
出 版 年：2004
分 類：抗發炎
論文結論：Fourteen compounds including zhankuic acids A, B, C, and antcin K were extracted by ethanol of the fruiting bodies of Antrodia camphorata. Inhibition of both ROS production and firm adhesion by neutrophils has no significant cytotoxic effect that could give these drugs the potential to be anti-inflammatory agents for the clinical treatment.
論文出處：J Agric Food Chem. 2003 Mar 12;51(6):1571-7.
論文名稱：Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats.
作 者：Song TY, Yen GC
出 版 年：2003
分 類：抗發炎
論文結論：The inhibitory effect of DMF and its crude triterpenoids on lipid peroxidation occurred in a dose-response manner in an AAPH/linoleic acid system. DMF may play a role in preventing oxidative damage in living systems by up-regulating hepatic GSH-dependent enzymes to preserve the normal GSH/GSSH ratio and scavenging free radicals formed during CCl(4) metabolism.
論文出處：J Agric Food Chem. 2003 May 21;51(11):3302-8.
論文名稱：Antioxidative and hepatoprotective effects of Antrodia camphorata extract.
作 者：Hsiao G, Shen MY, Lin KH, Lan MH, Wu LY, Chou DS, Lin CH, Su CH, Sheu JR.
出 版 年：2003
分 類：抗發炎
論文結論：Antrodia camphorata extract exerts effective protection against chronic chemical-induced hepatic injury in vivo, by mediating antioxidative and free radical scavenging activities.
論文出處：FEMS Microbiol Lett. 2002 Mar 19;209(1):63-7.
論文名稱：Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects.
作 者：Lee IH, Huang RL, Chen CT, Chen HC, Hsu WC, Lu MK
出 版 年：2002
分 類：抗發炎
論文結論：Polysaccharides were extracted from fruiting bodies and cultured mycelia from Antrodia camphorata. Strains B86 and 35398 had substantial anti-hepatitis B e antigen activities. None of the polysaccharides exhibited cytotoxic effects.
論文出處：J Agric Food Chem. 2002 May 22;50(11):3322-7.
論文名稱：Antioxidant properties of Antrodia camphorata in submerged culture.
作 者：Song TY, Yen GC
出 版 年：2002
分 類：抗發炎
論文結論：DMF showed the strongest inhibition of lipid peroxidation as a function of its concentration and marked activity in free radical scavenging. Water extract of mycelia (WEM) also showed marked activity in free radical scavenging. The rank of antioxidant ability: DMF>DMCM>hexane extract of mycelia. (The dry matter of cultural medium (DMCM), filtrate (DMF), and different solvent extracts of mycelia from Antrodia camphorata in submerged culture (ACSC))
論文出處：Life Sci. 2002 Jun 14;71(4):469-82.
論文名稱：Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes.
作 者：Hseu YC, Chang WC, Hseu YT, Lee CY, Yech YJ, Chen PC, Chen JY, Yang HL
出 版 年：2002
分 類：抗發炎
論文結論：Antrodia camphorata mycelia may have protective antioxidant and anticancer properties. (A. camphorata mycelia prevented the depletion of cytosolic antioxidant glutathione (GSH) and ATP in erythrocytes. Cultured human endothelial cell damage induced by AAPH was suppressed by A. camphorata mycelia. And A. camphorata mycelia exhibited significant cytotoxicity against leukemia HL-60 cells.)